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Chemical Compound Review

Quinamm     (5-ethenyl-1- azabicyclo[2.2.2]oct-7-yl)- (6...

Synonyms: Auriquin, Aflukin, Quinicardine, Coco-Quinine, GNF-PF-5473, ...
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Disease relevance of quinidine


Psychiatry related information on quinidine


High impact information on quinidine


Chemical compound and disease context of quinidine


Biological context of quinidine

  • The inhibition of metoprolol metabolism by quinidine (Qd) was 200 times more potent than that of quinine (Qn), both for alpha-hydroxylation (Qd IC50 = 0.05 microM; Qn IC50 = 4 microM) and O-demethylation (Qd IC50 = 0.05 microM; Qn IC50 = 4 microM) [14].
  • Control studies were carried out with quinine sulfate in the drinking water to decrease water intake to the level of the methadone-treated group [15].
  • Synchronous release delivery systems of SP containing also the P-gp inhibitor Qn were able to increase SP bioavailability after intestinal administration in the rat [16].
  • We examined the relationship between QTc prolongation and the pharmacokinetics of FK506 in guinea pigs in order to evaluate the arrhythmogenicity of FK506 in comparison with quinidine (QND) [17].
  • The number of circumvallate papillae was counted by direct observation with the naked eye; bitter taste thresholds were evaluated by the three drop forced-choice method with an ascending series, using quinine sulfate dehydrate as the bitter agent [18].

Anatomical context of quinidine

  • Jejunum of anesthetized rats was perfused with 200 or 400 microg/ml of SP either alone or together with 98 microg/ml of Ver. It was observed that while an increasing SP concentration did not cause an increase in SP blood levels, the addition of Ver or Qn to the perfusion solution caused a profound increase in SP absorption [16].
  • METHODS: The effect of 50 and 100 microM quinine sulfate on the invasive ability of Salmonella typhimurium and Shigella flexneri M90T into human colon adenocarcinoma-2 (Caco-2) cells was studied during the infection period [4].

Associations of quinidine with other chemical compounds

  • The plates were scanned and quantified at 226 nm for Qn, Cn, Cnd and for Qnd at 366 nm in fluorescence and reflectance mode ([symbol: see text] K400 filter) [19].
  • The derivative (7-OH quinoline; DER) and the internal standard (quinine-bisulfate; IS) were separated on a 10-micron particle, 8 mm x 10-cm C18 cartridge in conjunction with a radial compression system using a mixture of 0.05 M dibasic ammonium phosphate solution (pH 2.5):acetonitrile:methanol (92:6:2) at a flow rate of 3 mL/min as a mobile phase [20].
  • Parental line-F1 comparisons provided evidence for non-additive genetic variation for hedonic sensitivity towards QS and DEX, though in opposite directions [21].
  • 5. There was a significant influence of negative chronotropic effect on the inotropic potency and the order was: Lid > Qui > Dis > Toc > Apr > Mex. The potency of various drugs is clinically useful in the choice of drugs when considering cardiac function and heart rate [22].
  • Following an acclimation period of 5 d, male Sprague-Dawley rats were fasted for 4 d and sacrificed after taste stimulation with a palatable sodium saccharin or unpalatable quinine sulfate flavored diet [23].

Gene context of quinidine


Analytical, diagnostic and therapeutic context of quinidine


  1. Quinine sulfate for pain in the Guillain-Barré syndrome. Nixon, R.A. Ann. Neurol. (1978) [Pubmed]
  2. Drug monitoring of quinine in men with nonsevere falciparum malaria: study in the Amazon region of Brazil. Vieira, J.L., Midio, A.F. Therapeutic drug monitoring. (2001) [Pubmed]
  3. Selective sensitivity of synaptosomal membrane function to cerebral cortical hypoxia in newborn piglets. Razdan, B., Marro, P.J., Tammela, O., Goel, R., Mishra, O.P., Delivoria-Papadopoulos, M. Brain Res. (1993) [Pubmed]
  4. Quinine sulfate inhibits invasion of Salmonella typhimurium and Shigella flexneri: a preliminary study. Wolf, R., Grimaldi, E., Donnarumma, G., Greco, R., Auricchio, L., De Filippis, A., Tufano, M.A. Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association. (2005) [Pubmed]
  5. Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly. Baltodano, N., Gallo, B.V., Weidler, D.J. Arch. Intern. Med. (1988) [Pubmed]
  6. Negative dromotropic effects of class I antiarrhythmic drugs in anisotropic ventricular muscle. Iida, M., Kodama, I., Toyama, J. Cardiovasc. Res. (1996) [Pubmed]
  7. In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii. Holfels, E., McAuley, J., Mack, D., Milhous, W.K., McLeod, R. Antimicrob. Agents Chemother. (1994) [Pubmed]
  8. Membrane structural domains. Resolution limits using diphenylhexatriene fluorescence decay. Barrow, D.A., Lentz, B.R. Biophys. J. (1985) [Pubmed]
  9. Septic shock due to babesiosis. Dacey, M.J., Martinez, H., Raimondo, T., Brown, C., Brady, J. Clin. Infect. Dis. (2001) [Pubmed]
  10. Contribution of cytochrome P-4502D6 phenotype to the neuromodulatory effects of dextromethorphan. Desmeules, J.A., Oestreicher, M.K., Piguet, V., Allaz, A.F., Dayer, P. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  11. Effects of diet-induced hypokalaemia on the efficacy of antiarrhythmic drugs against ventricular arrhythmias evoked by coronary artery ligation in the anaesthetised rat. Winslow, E., Marshall, R.J., Campbell, J.K., Muir, A.W. J. Cardiovasc. Pharmacol. (1987) [Pubmed]
  12. Infection and transmission studies with Plasmodium gonderi in the Macaca mulatta monkey. Collins, W.E., Contacos, P.G. J. Parasitol. (1980) [Pubmed]
  13. Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women. Bounyasong, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2001) [Pubmed]
  14. Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast. Ellis, S.W., Ching, M.S., Watson, P.F., Henderson, C.J., Simula, A.P., Lennard, M.S., Tucker, G.T., Woods, H.F. Biochem. Pharmacol. (1992) [Pubmed]
  15. Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydrase in Wistar rats pretreated with oral methadone hydrochloride. Bellward, G.D., Gontovnick, L.S., Otten, M. Drug Metab. Dispos. (1977) [Pubmed]
  16. Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems. Baluom, M., Friedman, M., Rubinstein, A. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
  17. Sustained QT prolongation induced by tacrolimus in guinea pigs. Minematsu, T., Ohtani, H., Sato, H., Iga, T. Life Sci. (1999) [Pubmed]
  18. Bitter taste threshold and its relation to number of circumvallate papillae in the elderly. Mavi, A., Ceyhan, O. Aging (Milan, Italy) (1999) [Pubmed]
  19. HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. Ravishankara, M.N., Shrivastava, N., Padh, H., Rajani, M. Planta Med. (2001) [Pubmed]
  20. Determination of acrolein in urine by liquid chromatography and fluorescence detection of its quinoline derivative. al-Rawithi, S., el-Yazigi, A., Nicholls, P.J. Pharm. Res. (1993) [Pubmed]
  21. Genetic analyses of gustation in the fowl. Barbato, G.F., Siegel, P.B., Cherry, J.A. Physiol. Behav. (1982) [Pubmed]
  22. Relationship between negative inotropic and chronotropic effects of tocainide and five class I antiarrhythmic drugs in the coronary perfused guinea-pig heart. Matsumoto, T., Hasegawa, J., Mashiba, H. Gen. Pharmacol. (1993) [Pubmed]
  23. Effects of taste stimulation on the behavior of serum amino acid concentrations and amylase and trypsin activities in fasting rats. Naruse, M.M., Ohara, I., Kobayashi, T., Itokawa, Y., Seino, Y. J. Nutr. Sci. Vitaminol. (1999) [Pubmed]
  24. Quinine Sulfate Inhibits Invasion of Salmonella typhimurium and Shigella flexneri: A Preliminary Study. Walker, R. Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association. (2006) [Pubmed]
  25. An open comparative trial of Vanquin tablets and pripsen granules in the treatment of threadworm infestation. Molla, A.L., Donald, J.F. J. Int. Med. Res. (1977) [Pubmed]
  26. Factors effecting drug release from inert matrices. Part 1: effects of surfactants on the release of quinine sulfate. Choulis, N.H., Papadopoulos, H. Die Pharmazie. (1975) [Pubmed]
  27. Diurnal oscillations in the serum and salivary levels of quinidine. Rao, B.R., Rambhau, D. Arzneimittel-Forschung. (1995) [Pubmed]
  28. Detection of quinine and its metabolites in horse urine by gas chromatography-mass spectrometry. Demir, C., Brereton, R.G., Dumasia, M.C. The Analyst. (1996) [Pubmed]
  29. Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon. Moyou-Somo, R., Tietche, F., Ondoa, M., Kouemeni, L.E., Ekoe, T., Mbonda, E., Nsangou, C., Jemea, B., Guemkam, G. Am. J. Trop. Med. Hyg. (2001) [Pubmed]
  30. Relationship between plasma and saliva quinine levels in humans. Babalola, C.P., Bolaji, O.O., Ogunbona, F.A., Dixon, P.A. Therapeutic drug monitoring. (1996) [Pubmed]
  31. Abnormalities of the pupil and visual-evoked potential in quinine amblyopia. Gangitano, J.L., Keltner, J.L. Am. J. Ophthalmol. (1980) [Pubmed]
  32. Expedient liquid chromatographic method with fluorescence detection for montelukast sodium in micro-samples of plasma. Al-Rawithi, S., Al-Gazlan, S., Al-Ahmadi, W., Alshowaier, I.A., Yusuf, A., Raines, D.A. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
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