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MeSH Review:

Peganum

Xie, J. et al., Zayed, R. et al., Ma, Z.Z. et al., Ma, Z.Z. et al., Sharaf, M. et al., et al.

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Disease relevance of Peganum

The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek carcinoma, and UCP-Med sarcoma [1].

High impact information on Peganum

A coupled LC-MS (liquid-phase chromatography and mass spectrometry) system consisting of a combination of a column of molecularly imprinted polymer (MIP) and a MS detector was used for affinitive separation and on-line identification of the antitumor components, harmine and harmaline, from the methanol extract of Peganum nigellastrum seeds [2].
Two canthin-6-one alkaloids, luotonins C and D, and two phenylpropanoids, dihydrosinapyl ferulate and dihydroconiferyl ferulate, were isolated from the aerial parts of Peganum nigellastrum along with four known alkaloids, harmine, 3-phenylquinoline, 3-(4-hydroxyphenyl)quinoline and 3-(1H-indol-3-yl)quinoline [3].
Three new triterpenoids, 3alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were isolated from the roots of Peganum nigellastrum along with four known lupene-type triterpenoids [4].
Four flavonoid glycosides from Peganum harmala [5].
The aerial parts of Peganum harmala yielded four new flavonoids: acacetin 7-O-rhamnoside, 7-O-[6"-O-glucosyl-2"-O-(3'''-acetylrhamnosyl)glucoside and 7-O-(2'''-O-rhamnosyl-2"-O-glucosylglucoside), and the glycoflavone 2'''-O-rhamnosyl-2"-O-glucosylcytisoside [5].

Associations of Peganum with chemical compounds

Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test [6].
Eighty two cattle naturally infected with haemosporidians were treated with total alkaloid hydrochloride of Peganum harmale L [7].
Relaxant activity of methanolic extract from seeds of Peganum harmala on isolated rat aorta [8].
Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala [9].
In root cultures, the formation of beta-carboline alkaloids can be induced by methyljasmonate and several other elicitors indicating that these alkaloids are part of the reactive chemical defence system of Peganum harmala [9].

References

In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Lamchouri, F., Settaf, A., Cherrah, Y., Hassar, M., Zemzami, M., Atif, N., Nadori, E.B., Zaid, A., Lyoussi, B. Fitoterapia (2000) [Pubmed]
Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry. Xie, J., Zhu, L., Xu, X. Anal. Chem. (2002) [Pubmed]
Alkaloids and phenylpropanoids from Peganum nigellastrum. Ma, Z.Z., Hano, Y., Nomura, T., Chen, Y.J. Phytochemistry (2000) [Pubmed]
Three new triterpenoids from Peganum nigellastrum. Ma, Z.Z., Hano, Y., Nomura, T., Chen, Y.J. J. Nat. Prod. (2000) [Pubmed]
Four flavonoid glycosides from Peganum harmala. Sharaf, M., el-Ansari, M.A., Matlin, S.A., Saleh, N.A. Phytochemistry (1997) [Pubmed]
Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. Monsef, H.R., Ghobadi, A., Iranshahi, M., Abdollahi, M. Journal of pharmacy & pharmaceutical sciences [electronic resource] : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. (2004) [Pubmed]
Observations on the treatment of natural haemosporidia infections by total alkaloid of Peganum harmala L. in cattle. Hu, T., Fan, B., Liang, J., Zhao, S., Dang, P., Gao, F., Dong, M. Tropical animal health and production. (1997) [Pubmed]
Relaxant activity of methanolic extract from seeds of Peganum harmala on isolated rat aorta. Berrougui, H., Herrera-Gonzalez, M.D., Marhuenda, E., Ettaib, A., Hmamouchi, M. Thérapie. (2002) [Pubmed]
Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala. Zayed, R., Wink, M. Z. Naturforsch., C, J. Biosci. (2005) [Pubmed]

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