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MeSH Review

Mikania

 
 
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High impact information on Mikania

  • Mikania glomerata is a plant popularly used to treat respiratory diseases and is reported to have flavonoids and coumarin, which have been shown to have antifertility activity in male dogs and female rats, respectively [1].
  • Evaluation of long-term exposure to Mikania glomerata (Sprengel) extract on male Wistar rats' reproductive organs, sperm production and testosterone level [1].
  • The effects of aqueous extracts and hydro-alcoholic extract (HAE), and of a dichloromethane fraction (MG1) obtained from the HAE of Mikania glomerata leaves on isolated respiratory and vascular smooth muscle have been investigated [2].
  • Mikanin-3-O-sulfate (1), in the form of its potassium salt, together with mikanin (2) and alpinetin (3) were isolated from Mikania micrantha [3].
  • Fourteen novel sesquiterpene lactones of the germacranolide type have been isolated from the aerial parts of Mikania guaco: six costunolide, two melampolide and six germacra-4-trans,10(14),11(13)-trien-12.6alpha-olide derivatives [4].
 

Biological context of Mikania

  • The infusions of Mikania laevigata, negative for mutagenic activity, showed high percentages of inhibition of mutagenesis induced by mutagens 2AF (2-amino fluorene), in the presence of exogenous metabolism (S9 fraction), for frameshift (TA98) and base pair substitution (TA100) lesions [5].
 

Associations of Mikania with chemical compounds

  • The anti-ulcerogenic effect of an alkaloidal fraction from Mikania cordata on diclofenac sodium-induced gastrointestinal lesions in rats [6].
  • The data indicate that the biologically active compounds are present mostly in the hexane fraction of both Mikania species, which showed remarkable inhibitory activities against mutans streptococci [7].
  • Phytochemical screening of the crude hydroalcoholic 70% extract (CHE) of Mikania laevigata Shultz Bip. revealed coumarins, terpenes and organic acids [8].
  • Stimulation of hepatic protein synthesis in response to Mikania cordata root extract in carbon tetrachloride-induced hepatotoxicity in mice [9].
  • The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice [10].
 

Gene context of Mikania

  • Aqueous extracts, prepared from dried or fresh roots, stems or leaves of Mikania glomerata, a plant found in Mata Atlântica in Southeastern Brazil, were able to efficiently neutralize different toxic, pharmacological, and enzymatic effects induced by venoms from Bothrops and Crotalus snakes [11].

References

  1. Evaluation of long-term exposure to Mikania glomerata (Sprengel) extract on male Wistar rats' reproductive organs, sperm production and testosterone level. da Silveira e Sá, R.d.e. .C., Leite, M.N., Reporedo, M.d.e. .M., de Almeida, R.N. Contraception. (2003) [Pubmed]
  2. Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig trachea. Soares de Moura, R., Costa, S.S., Jansen, J.M., Silva, C.A., Lopes, C.S., Bernardo-Filho, M., Nascimento da Silva, V., Criddle, D.N., Portela, B.N., Rubenich, L.M., Araujo, R.G., Carvalho, L.C. J. Pharm. Pharmacol. (2002) [Pubmed]
  3. A novel 1:1 complex of potassium mikanin-3-O-sulfate with methanol. Jiang, R.W., He, Z.D., But, P.P., Chan, Y.M., Ma, S.C., Mak, T.C. Chem. Pharm. Bull. (2001) [Pubmed]
  4. Germacranolides from Mikania guaco. Rüngeler, P., Brecht, V., Tamayo-Castillo, G., Merfort, I. Phytochemistry (2001) [Pubmed]
  5. Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. Fernandes, J.B., Vargas, V.M. Phytotherapy research : PTR. (2003) [Pubmed]
  6. The anti-ulcerogenic effect of an alkaloidal fraction from Mikania cordata on diclofenac sodium-induced gastrointestinal lesions in rats. Mosaddik, M.A., Alam, K.M. J. Pharm. Pharmacol. (2000) [Pubmed]
  7. Effects of Mikania genus plants on growth and cell adherence of mutans streptococci. Yatsuda, R., Rosalen, P.L., Cury, J.A., Murata, R.M., Rehder, V.L., Melo, L.V., Koo, H. Journal of ethnopharmacology. (2005) [Pubmed]
  8. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Bighetti, A.E., Antônio, M.A., Kohn, L.K., Rehder, V.L., Foglio, M.A., Possenti, A., Vilela, L., Carvalho, J.E. Phytomedicine (2005) [Pubmed]
  9. Stimulation of hepatic protein synthesis in response to Mikania cordata root extract in carbon tetrachloride-induced hepatotoxicity in mice. Mandal, P.K., Bishayee, A., Chatterjee, M. Ital. J. Biochem. (1992) [Pubmed]
  10. Analgesic sesquiterpene dilactone from Mikania cordata. Ahmed, M., Rahman, M.T., Alimuzzaman, M., Shilpi, J.A. Fitoterapia (2001) [Pubmed]
  11. Antiophidian properties of the aqueous extract of Mikania glomerata. Maiorano, V.A., Marcussi, S., Daher, M.A., Oliveira, C.Z., Couto, L.B., Gomes, O.A., França, S.C., Soares, A.M., Pereira, P.S. Journal of ethnopharmacology. (2005) [Pubmed]
 
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