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MeSH Review:

Herb-Drug Interactions

Yin, O.Q. et al., Williamson, E.M., Gurley, B.J. et al., Featherstone, C. et al., Kuo, Y.H. et al., et al.

Zhou, Lim, Chowbay, Gurley, Barone, Williams, Carrier, Breen, Yates, Song, Hubbard, Tong, Cheboyina, Featherstone, Godden, Selvaraj, Emslie, Took-Zozaya, Williamson, Gurley, Gardner, Hubbard, Williams, Gentry, Cui, Ang,

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High impact information on Herb-Drug Interactions

OBJECTIVES: Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions [1].
This study was designed to investigate the potential herb-drug interaction between G. biloba and omeprazole, a widely used CYP2C19 substrate, in subjects with different CYP2C19 genotypes [2].
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole [2].
Thus, the modulation of intestinal Pgp and CYP3A4 represents an important mechanism for many clinically important herb-drug interactions [3].
Inhibition of CYP3A has important implications for potential herbal-drug interactions [4].

Associations of Herb-Drug Interactions with chemical compounds

CONCLUSIONS: Botanical supplements containing C aurantium , milk thistle, or saw palmetto extracts appear to pose a minimal risk for CYP-mediated herb-drug interactions in humans [5].
Until reports of interactions between St John's wort and drugs such as digoxin, warfarin, protease inhibitors and oral contraceptives began to appear, very few herb-drug interactions were documented [6].
CASE SUMMARY: A 35-year-old woman lost 5 L of blood during surgery as a result of a possible herb-drug interaction between Aloe vera and sevoflurane [7].
To assess possible herb-drug interactions, the effects of the aqueous and ethyl acetate extracts of S. miltiorrhiza on cytochrome P450 (CYP) were studied [8].
It is suggested that the herb-drug interaction may occur through the induction of the metabolism of theophylline [9].

Gene context of Herb-Drug Interactions

CONCLUSIONS: Single-time point phenotypic metabolic ratios may provide a practical means of predicting CYP-mediated herb-drug interactions in humans [10].
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may underlie many herb-drug interactions [11].
The involvement of the NHS in CAM delivery was small but there is a significant role to ensure patient safety, especially regarding herb-drug interactions [12].

References

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A., Shah, A. Clin. Pharmacol. Ther. (2005) [Pubmed]
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Yin, O.Q., Tomlinson, B., Waye, M.M., Chow, A.H., Chow, M.S. Pharmacogenetics (2004) [Pubmed]
Herbal modulation of P-glycoprotein. Zhou, S., Lim, L.Y., Chowbay, B. Drug Metab. Rev. (2004) [Pubmed]
In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats. Wadsworth, T., Poonyagariyagorn, H., Sullivan, E., Koop, D., Roselli, C.E. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Carrier, J., Khan, I.A., Edwards, D.J., Shah, A. Clin. Pharmacol. Ther. (2004) [Pubmed]
Drug interactions between herbal and prescription medicines. Williamson, E.M. Drug safety : an international journal of medical toxicology and drug experience. (2003) [Pubmed]
Possible interaction between sevoflurane and Aloe vera. Lee, A., Chui, P.T., Aun, C.S., Gin, T., Lau, A.S. The Annals of pharmacotherapy. (2004) [Pubmed]
Induction of cytochrome P450-dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza. Kuo, Y.H., Lin, Y.L., Don, M.J., Chen, R.M., Ueng, Y.F. J. Pharm. Pharmacol. (2006) [Pubmed]
Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats. Jan, W.C., Lin, L.C., Chieh-Fu-Chen, n.u.l.l., Tsai, T.H. Journal of ethnopharmacology. (2005) [Pubmed]
Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Cui, Y., Ang, C.Y. Clin. Pharmacol. Ther. (2002) [Pubmed]
Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Gurley, B.J., Barone, G.W., Williams, D.K., Carrier, J., Breen, P., Yates, C.R., Song, P.F., Hubbard, M.A., Tong, Y., Cheboyina, S. Drug Metab. Dispos. (2006) [Pubmed]
Characteristics associated with reported CAM use in patients attending six GP practices in the Tayside and Grampian regions of Scotland: a survey. Featherstone, C., Godden, D., Selvaraj, S., Emslie, M., Took-Zozaya, M. Complementary therapies in medicine. (2003) [Pubmed]

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