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MeSH Review


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Disease relevance of Hypericum


Psychiatry related information on Hypericum


High impact information on Hypericum


Chemical compound and disease context of Hypericum


Biological context of Hypericum


Anatomical context of Hypericum


Associations of Hypericum with chemical compounds


Gene context of Hypericum

  • St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 [31].
  • Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects [33].
  • RESULTS: Comparisons of presupplementation and postsupplementation ratios indicated that St John's wort significantly induced the activity of CYP2E1 and CYP3A4 (P <.0001) [34].
  • Reduced therapeutic efficacy of drugs metabolized by CYP3A should be anticipated during long-term administration of St John's wort [35].
  • There was no change in CYP1A2, CYP2C9, or CYP2D6 activities as a result of St John's wort administration [35].

Analytical, diagnostic and therapeutic context of Hypericum


  1. Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia. Quiney, C., Billard, C., Faussat, A.M., Salanoubat, C., Ensaf, A., Naït-Si, Y., Fourneron, J.D., Kolb, J.P. Leukemia (2006) [Pubmed]
  2. Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase. Neary, J.T., Whittemore, S.R., Bu, Y., Mehta, H., Shi, Y.F. Pharmacopsychiatry (2001) [Pubmed]
  3. Hypericum perforatum attenuates the development of cerulein-induced acute pancreatitis in mice. Genovese, T., Mazzon, E., Di Paola, R., Muià, C., Crisafulli, C., Menegazzi, M., Malleo, G., Suzuki, H., Cuzzocrea, S. Shock (2006) [Pubmed]
  4. Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Murphy, P.A., Kern, S.E., Stanczyk, F.Z., Westhoff, C.L. Contraception. (2005) [Pubmed]
  5. Aqueous ethanolic extract of St. John's wort (Hypericum perforatum L.) induces growth inhibition and apoptosis in human malignant cells in vitro. Hostanska, K., Reichling, J., Bommer, S., Weber, M., Saller, R. Die Pharmazie. (2002) [Pubmed]
  6. In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear. Philippu, A. Pharmacopsychiatry (2001) [Pubmed]
  7. Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Schrader, E. International clinical psychopharmacology. (2000) [Pubmed]
  8. Effectiveness of treatments for depression in older people. Frazer, C.J., Christensen, H., Griffiths, K.M. Med. J. Aust. (2005) [Pubmed]
  9. Hyperforin as a possible antidepressant component of hypericum extracts. Chatterjee, S.S., Bhattacharya, S.K., Wonnemann, M., Singer, A., Müller, W.E. Life Sci. (1998) [Pubmed]
  10. Natural and complementary therapies for substance use disorders. Dean, A.J. Current opinion in psychiatry. (2005) [Pubmed]
  11. Drug interaction of St John's wort with cyclosporin. Breidenbach, T., Hoffmann, M.W., Becker, T., Schlitt, H., Klempnauer, J. Lancet (2000) [Pubmed]
  12. Indinavir concentrations and St John's wort. Piscitelli, S.C., Burstein, A.H., Chaitt, D., Alfaro, R.M., Falloon, J. Lancet (2000) [Pubmed]
  13. Antibacterial activity of hyperforin from St John's wort. Ebrey, R.J. Lancet (1999) [Pubmed]
  14. St John's wort: Prozac from the plant kingdom. Di Carlo, G., Borrelli, F., Ernst, E., Izzo, A.A. Trends Pharmacol. Sci. (2001) [Pubmed]
  15. Is St John's wort a 'Prozac-like' herbal antidepressant? Gobbi, M., Mennini, T. Trends Pharmacol. Sci. (2001) [Pubmed]
  16. St John's wort or sertraline? Randomized controlled trial in primary care. van Gurp, G., Meterissian, G.B., Haiek, L.N., McCusker, J., Bellavance, F. Canadian family physician Médecin de famille canadien. (2002) [Pubmed]
  17. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. Preuss, H.G., DiFerdinando, D., Bagchi, M., Bagchi, D. Journal of medicine. (2002) [Pubmed]
  18. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Schempp, C.M., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Kiss, J., Termeer, C.C., Gilb, B., Kaufmann, T., Borner, C., Sleeman, J.P., Simon, J.C. Oncogene (2002) [Pubmed]
  19. Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics. Rengelshausen, J., Banfield, M., Riedel, K.D., Burhenne, J., Weiss, J., Thomsen, T., Walter-Sack, I., Haefeli, W.E., Mikus, G. Clin. Pharmacol. Ther. (2005) [Pubmed]
  20. Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction. Mai, I., Bauer, S., Perloff, E.S., Johne, A., Uehleke, B., Frank, B., Budde, K., Roots, I. Clin. Pharmacol. Ther. (2004) [Pubmed]
  21. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Johne, A., Brockmöller, J., Bauer, S., Maurer, A., Langheinrich, M., Roots, I. Clin. Pharmacol. Ther. (1999) [Pubmed]
  22. St. John's wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 mothers and 2 infants. Klier, C.M., Schmid-Siegel, B., Schäfer, M.R., Lenz, G., Saria, A., Lee, A., Zernig, G. The Journal of clinical psychiatry. (2006) [Pubmed]
  23. St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Butterweck, V., Winterhoff, H., Herkenham, M. Mol. Psychiatry (2001) [Pubmed]
  24. Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures. Komoroski, B.J., Parise, R.A., Egorin, M.J., Strom, S.C., Venkataramanan, R. Clin. Cancer Res. (2005) [Pubmed]
  25. Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway. Zhou, C., Tabb, M.M., Sadatrafiei, A., Grün, F., Sun, A., Blumberg, B. J. Clin. Immunol. (2004) [Pubmed]
  26. Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum. Kang, B.Y., Chung, S.W., Kim, T.S. Planta Med. (2001) [Pubmed]
  27. Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens. Rommelspacher, H., Siemanowitz, B., Mannel, M. Pharmacopsychiatry (2001) [Pubmed]
  28. Acute heart transplant rejection due to Saint John's wort. Ruschitzka, F., Meier, P.J., Turina, M., Lüscher, T.F., Noll, G. Lancet (2000) [Pubmed]
  29. A systematic review of newer pharmacotherapies for depression in adults: evidence report summary. Williams, J.W., Mulrow, C.D., Chiquette, E., Noël, P.H., Aguilar, C., Cornell, J. Ann. Intern. Med. (2000) [Pubmed]
  30. Induction of imatinib metabolism by hypericum perforatum. Smith, P.F., Bullock, J.M., Booker, B.M., Haas, C.E., Berenson, C.S., Jusko, W.J. Blood (2004) [Pubmed]
  31. St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. Schwarz, D., Kisselev, P., Roots, I. Cancer Res. (2003) [Pubmed]
  32. St John's wort interaction with digoxin. Cheng, T.O. Arch. Intern. Med. (2000) [Pubmed]
  33. Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Dresser, G.K., Schwarz, U.I., Wilkinson, G.R., Kim, R.B. Clin. Pharmacol. Ther. (2003) [Pubmed]
  34. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Cui, Y., Ang, C.Y. Clin. Pharmacol. Ther. (2002) [Pubmed]
  35. The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. Wang, Z., Gorski, J.C., Hamman, M.A., Huang, S.M., Lesko, L.J., Hall, S.D. Clin. Pharmacol. Ther. (2001) [Pubmed]
  36. Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases. Liu, B., Falkenstein-Paul, H., Schmidt, W., Beerhues, L. Plant J. (2003) [Pubmed]
  37. St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Dürr, D., Stieger, B., Kullak-Ublick, G.A., Rentsch, K.M., Steinert, H.C., Meier, P.J., Fattinger, K. Clin. Pharmacol. Ther. (2000) [Pubmed]
  38. Interaction of Hypericum perforatum (St. John's wort) with cyclosporin A metabolism in a patient after liver transplantation. Karliova, M., Treichel, U., Malagò, M., Frilling, A., Gerken, G., Broelsch, C.E. J. Hepatol. (2000) [Pubmed]
  39. Air/light-free hyphenated extraction/analysis system: supercritical fluid extraction on-line coupled with liquid chromatography-UV absorbance/electrospray mass spectrometry for the determination of hyperforin and its degradation products in Hypericum pertoratum. Wang, Z., Ashraf-Khorassani, M., Taylor, L.T. Anal. Chem. (2004) [Pubmed]
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