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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Aloe


High impact information on Aloe


Chemical compound and disease context of Aloe


Biological context of Aloe


Anatomical context of Aloe


Associations of Aloe with chemical compounds


Gene context of Aloe

  • Furthermore, these results indicate that Aloe vera contains a compound(s) that neutralizes, binds with FGF-2 receptor, or otherwise alters signaling pathways for FGF-2 [21].
  • The release of interleukin-8 by CaCo2 cells fell by 20% (P < 0.05) with aloe vera diluted at 1 in 100, but not at 1 in 10 or 1 in 1000 dilutions [1].
  • Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts [22].
  • A specially designed questionnaire was used for the use of Aloe vera, reasons and location of application, adverse reactions, occupation, hobbies and atopy [23].
  • Increases in liver UDPGT, GGT, and GSTP activities were also observed with cancer induction that were again suppressed with either vitamin C or aloe vera gel supplementation [24].

Analytical, diagnostic and therapeutic context of Aloe


  1. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Langmead, L., Makins, R.J., Rampton, D.S. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  2. Effects of dexpanthenol with or without Aloe vera extract on radiation-induced oral mucositis: preclinical studies. Dörr, W., Schlichting, S., Bray, M.A., Flockhart, I.R., Hopewell, J.W. Int. J. Radiat. Biol. (2005) [Pubmed]
  3. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. Eamlamnam, K., Patumraj, S., Visedopas, N., Thong-Ngam, D. World J. Gastroenterol. (2006) [Pubmed]
  4. The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis in rats. Korkina, L., Suprun, M., Petrova, A., Mikhal'chik, E., Luci, A., De Luca, C. Biofactors (2003) [Pubmed]
  5. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Garnick, J.J., Singh, B., Winkley, G. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1998) [Pubmed]
  6. Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.) Berg. Leung, M.Y., Liu, C., Zhu, L.F., Hui, Y.Z., Yu, B., Fung, K.P. Glycobiology (2004) [Pubmed]
  7. A combination of aloe vera, curcumin, vitamin C, and taurine increases canine fibroblast migration and decreases tritiated water diffusion across canine keratinocytes in vitro. Fray, T.R., Watson, A.L., Croft, J.M., Baker, C.D., Bailey, J., Sirel, N., Tobias, A., Markwell, P.J. J. Nutr. (2004) [Pubmed]
  8. Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. Lee, K.Y., Park, J.H., Chung, M.H., Park, Y.I., Kim, K.W., Lee, Y.J., Lee, S.K. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  9. The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Choi, S.W., Son, B.W., Son, Y.S., Park, Y.I., Lee, S.K., Chung, M.H. Br. J. Dermatol. (2001) [Pubmed]
  10. Possible interaction between sevoflurane and Aloe vera. Lee, A., Chui, P.T., Aun, C.S., Gin, T., Lau, A.S. The Annals of pharmacotherapy. (2004) [Pubmed]
  11. Treatment of experimental frostbite with pentoxifylline and aloe vera cream. Miller, M.B., Koltai, P.J. Arch. Otolaryngol. Head Neck Surg. (1995) [Pubmed]
  12. In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera. Djeraba, A., Quere, P. Int. J. Immunopharmacol. (2000) [Pubmed]
  13. Topical use of aloe vera derived allantoin gel in otolaryngology. Thompson, J.E. Ear, nose, & throat journal. (1991) [Pubmed]
  14. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Zhang, L., Tizard, I.R. Immunopharmacology (1996) [Pubmed]
  15. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Chithra, P., Sajithlal, G.B., Chandrakasan, G. Mol. Cell. Biochem. (1998) [Pubmed]
  16. Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn). Womble, D., Helderman, J.H. Int. J. Immunopharmacol. (1988) [Pubmed]
  17. Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera. Karaca, K., Sharma, J.M., Nordgren, R. Int. J. Immunopharmacol. (1995) [Pubmed]
  18. Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from aloe vera gel. Yagi, A., Kabash, A., Mizuno, K., Moustafa, S.M., Khalifa, T.I., Tsuji, H. Planta Med. (2003) [Pubmed]
  19. Experimental and clinical observations on frostbite. Heggers, J.P., Robson, M.C., Manavalen, K., Weingarten, M.D., Carethers, J.M., Boertman, J.A., Smith, D.J., Sachs, R.J. Annals of emergency medicine. (1987) [Pubmed]
  20. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S.M., Khalifa, T.I. Planta Med. (2002) [Pubmed]
  21. Effects of Aloe vera on gap junctional intercellular communication and proliferation of human diabetic and nondiabetic skin fibroblasts. Abdullah, K.M., Abdullah, A., Johnson, M.L., Bilski, J.J., Petry, K., Redmer, D.A., Reynolds, L.P., Grazul-Bilska, A.T. Journal of alternative and complementary medicine (New York, N.Y.) (2003) [Pubmed]
  22. Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts. Hu, Y., Xu, J., Hu, Q. J. Agric. Food Chem. (2003) [Pubmed]
  23. Absence of contact sensitization to Aloe vera (L.) Burm. f. Reider, N., Issa, A., Hawranek, T., Schuster, C., Aberer, W., Kofler, H., Fritsch, P., Hausen, B.M. Contact Derm. (2005) [Pubmed]
  24. Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat. Shamaan, N.A., Kadir, K.A., Rahmat, A., Ngah, W.Z. Nutrition (Burbank, Los Angeles County, Calif.) (1998) [Pubmed]
  25. Aloe vera: a systematic review of its clinical effectiveness. Vogler, B.K., Ernst, E. The British journal of general practice : the journal of the Royal College of General Practitioners. (1999) [Pubmed]
  26. Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs. Rodríguez-Bigas, M., Cruz, N.I., Suárez, A. Plast. Reconstr. Surg. (1988) [Pubmed]
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