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Chemical Compound Review

Aurantiol     methyl 2-[(7-hydroxy-3,7-dimethyl...

Synonyms: Aurantium, AGN-PC-00SGM5, SureCN1171575, SureCN2502370, NSC-78483, ...
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Disease relevance of NSC78483

  • Safety and efficacy of citrus aurantium for weight loss [1].
  • The genetic analysis of virus-plant interaction in the family derived from C. aurantium after a CTV chronic infection showed the segregation of five types of interaction, which is not compatible with the hypothesis of a single gene controlling resistance [2].
  • Halomonas halocynthiae sp. nov., isolated from the marine ascidian Halocynthia aurantium [3].
  • Mice were orally (gavage) pretreated with solutions of citrus peel extract (Citrus aurantium var. amara) prepared at three different doses (100, 200 and 400 mg kg(-1;) body weight) for 7 consecutive days [4].
  • CONCLUSIONS: The use of C. aurantium-containing supplements may present as a risk for cardiovascular toxicity; however, additional studies/case reports are needed to validate this conclusion [5].

Psychiatry related information on NSC78483


High impact information on NSC78483


Chemical compound and disease context of NSC78483


Biological context of NSC78483

  • CONCLUSIONS: Botanical supplements containing C aurantium , milk thistle, or saw palmetto extracts appear to pose a minimal risk for CYP-mediated herb-drug interactions in humans [8].
  • 3. Messenger RNA of the ascidian neuronal Na+ channel, TuNa I, was detected using RT-PCR in a4-2-derived partial embryos of Halocynthia aurantium as well as in the cleavage-arrested a4-2 blastomeres treated with bFGF, confirming the neural inducer activity of bFGF during ascidian embryogenesis [10].
  • Five genetic linkage maps were constructed for the parents of three progenies: Citrus aurantium (A) x Poncirus trifoliata var [16].
  • A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 micrograms/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium [17].
  • The assessment of several parameters related to the biotransformation of mutagens/carcinogens showed that the metabolic machinery of sponge medulla cells is mainly oriented towards detoxification, with some differences depending on species (Geodia cydonium or Tethya aurantium) [18].

Anatomical context of NSC78483


Associations of NSC78483 with other chemical compounds


Gene context of NSC78483

  • Also studied with the Briggs-Rauscher reaction method was the antioxidant activity of cyanidin 3-O-beta-glucopyranoside (from Citrus aurantium) in order to compare the results with those obtained by other methods [28].
  • Citrus aurantium L. is commonly used as an alternative treatment for insomnia, anxiety and epilepsy [29].

Analytical, diagnostic and therapeutic context of NSC78483


  1. Safety and efficacy of citrus aurantium for weight loss. Bent, S., Padula, A., Neuhaus, J. Am. J. Cardiol. (2004) [Pubmed]
  2. Expressed sequence enrichment for candidate gene analysis of citrus tristeza virus resistance. Bernet, G.P., Bretó, M.P., Asins, M.J. Theor. Appl. Genet. (2004) [Pubmed]
  3. Halomonas halocynthiae sp. nov., isolated from the marine ascidian Halocynthia aurantium. Romanenko, L.A., Schumann, P., Rohde, M., Mikhailov, V.V., Stackebrandt, E. Int. J. Syst. Evol. Microbiol. (2002) [Pubmed]
  4. Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells. Hosseinimehr, S.J., Karami, M. J. Pharm. Pharmacol. (2005) [Pubmed]
  5. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Nykamp, D.L., Fackih, M.N., Compton, A.L. The Annals of pharmacotherapy. (2004) [Pubmed]
  6. Citrus aurantium used for weight loss by an adolescent with anorexia nervosa. Gray, S., Woolf, A.D. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (2005) [Pubmed]
  7. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Haller, C.A., Benowitz, N.L., Jacob, P. Am. J. Med. (2005) [Pubmed]
  8. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Carrier, J., Khan, I.A., Edwards, D.J., Shah, A. Clin. Pharmacol. Ther. (2004) [Pubmed]
  9. Changes of lectin-binding sites on the embryonic muscle cell surface in the developing ascidian, Halocynthia aurantium. Kawai, N., Nishiyama, F., Hirano, H. Exp. Cell Res. (1979) [Pubmed]
  10. Basic fibroblast growth factor induction of neuronal ion channel expression in ascidian ectodermal blastomeres. Inazawa, T., Okamura, Y., Takahashi, K. J. Physiol. (Lond.) (1998) [Pubmed]
  11. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. Penzak, S.R., Jann, M.W., Cold, J.A., Hon, Y.Y., Desai, H.D., Gurley, B.J. Journal of clinical pharmacology. (2001) [Pubmed]
  12. Dietary herbal supplements with phenylephrine for weight loss. Greenway, F., de Jonge-Levitan, L., Martin, C., Roberts, A., Grundy, I., Parker, C. Journal of medicinal food (2006) [Pubmed]
  13. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Haaz, S., Fontaine, K.R., Cutter, G., Limdi, N., Perumean-Chaney, S., Allison, D.B. Obesity reviews : an official journal of the International Association for the Study of Obesity. (2006) [Pubmed]
  14. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. Preuss, H.G., DiFerdinando, D., Bagchi, M., Bagchi, D. Journal of medicine. (2002) [Pubmed]
  15. Metabolism of some carcinogenic aromatic amines in four species of marine sponges. Kurelec, B., Britvić, S., Krca, S., Müller, W.E., Zahn, R.K. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1987) [Pubmed]
  16. Comparison between Poncirus and Citrus genetic linkage maps. Ruiz, C., Asins, M.J. Theor. Appl. Genet. (2003) [Pubmed]
  17. Isolation and structure of the marine sponge cell growth inhibitory cyclic peptide phakellistatin 1. Pettit, G.R., Cichacz, Z., Barkoczy, J., Dorsaz, A.C., Herald, D.L., Williams, M.D., Doubek, D.L., Schmidt, J.M., Tackett, L.P., Brune, D.C. J. Nat. Prod. (1993) [Pubmed]
  18. Biotransformation of genotoxic agents in marine sponges. Mechanisms and modulation. De Flora, S., Bagnasco, M., Bennicelli, C., Camoirano, A., Bojnemirski, A., Kurelec, B. Mutagenesis (1995) [Pubmed]
  19. Neural differentiation in cleavage-arrested ascidian blastomeres induced by a proteolytic enzyme. Okado, H., Takahashi, K. J. Physiol. (Lond.) (1993) [Pubmed]
  20. Comparison of properties of calcium channels between the differentiated 1-cell embryo and the egg cell of ascidians. Hirano, T., Takahashi, K. J. Physiol. (Lond.) (1984) [Pubmed]
  21. Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. Jang, W.S., Kim, K.N., Lee, Y.S., Nam, M.H., Lee, I.H. FEBS Lett. (2002) [Pubmed]
  22. Effect of humidity on cuticular water permeability of isolated cuticular membranes and leaf disks. Schreiber, L., Skrabs, M., Hartmann, K.D., Diamantopoulos, P., Simanova, E., Santrucek, J. Planta (2001) [Pubmed]
  23. Spatial distribution of sponge-associated bacteria in the Mediterranean sponge Tethya aurantium. Thiel, V., Neulinger, S.C., Staufenberger, T., Schmaljohann, R., Imhoff, J.F. FEMS Microbiol. Ecol. (2007) [Pubmed]
  24. Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericarps of Citrus grandis. Hou, Y.C., Hsiu, S.L., Tsao, C.W., Wang, Y.H., Chao, P.D. Planta Med. (2000) [Pubmed]
  25. A rapid and simple procedure for the determination of synephrine in dietary supplements by gas chromatography-mass spectrometry. Marchei, E., Pichini, S., Pacifici, R., Pellegrini, M., Zuccaro, P. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  26. Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. Pellati, F., Benvenuti, S., Melegari, M., Firenzuoli, F. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  27. Availability of weight-loss supplements: results of an audit of retail outlets in a southeastern city. Sharpe, P.A., Granner, M.L., Conway, J.M., Ainsworth, B.E., Dobre, M. Journal of the American Dietetic Association (2006) [Pubmed]
  28. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. Cervellati, R., Renzulli, C., Guerra, M.C., Speroni, E. J. Agric. Food Chem. (2002) [Pubmed]
  29. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Carvalho-Freitas, M.I., Costa, M. Biol. Pharm. Bull. (2002) [Pubmed]
  30. Simultaneous quantification of adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietary supplements by liquid chromatography. Avula, B., Upparapalli, S.K., Navarrete, A., Khan, I.A. Journal of AOAC International. (2005) [Pubmed]
  31. Changes of the volatile profile and artifact formation in Daidai (Citrus aurantium) cold-pressed peel oil on storage. Njoroge, S.M., Ukeda, H., Sawamura, M. J. Agric. Food Chem. (2003) [Pubmed]
  32. Zygotic and nucellar embryo survival following dehydration and cryopreservation of citrus intact seeds. Lambardi, M., De Carlo, A., Biricolti, S., Puglia, A.M., Lombardo, G., Siragusa, M., De Pasquale, F. Cryo letters. (2004) [Pubmed]
  33. An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'. Zhang, H.J., Cheng, Y.Y. Biomed. Chromatogr. (2006) [Pubmed]
  34. Consumption of Dietary Supplements Containing Citrus aurantium (Bitter Orange)--2004 California Behavioral Risk Factor Surveillance Survey (BRFSS). Klontz, K.C., Timbo, B.B., Street, D. The Annals of pharmacotherapy. (2006) [Pubmed]
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