Disease relevance of NSC78483

• Safety and efficacy of citrus aurantium for weight loss [1].
• The genetic analysis of virus-plant interaction in the family derived from C. aurantium after a CTV chronic infection showed the segregation of five types of interaction, which is not compatible with the hypothesis of a single gene controlling resistance [2].
• Halomonas halocynthiae sp. nov., isolated from the marine ascidian Halocynthia aurantium [3].
• Mice were orally (gavage) pretreated with solutions of citrus peel extract (Citrus aurantium var. amara) prepared at three different doses (100, 200 and 400 mg kg(-1;) body weight) for 7 consecutive days [4].
• CONCLUSIONS: The use of C. aurantium-containing supplements may present as a risk for cardiovascular toxicity; however, additional studies/case reports are needed to validate this conclusion [5].

Psychiatry related information on NSC78483

• Citrus aurantium used for weight loss by an adolescent with anorexia nervosa [6].
• A 16-year-old woman with an eating disorder admitted to taking a Citrus aurantium-containing dietary supplement for weight loss purposes [6].

High impact information on NSC78483

• Our aim was to characterize the pharmacokinetics and cardiovascular effects of C. aurantium dietary supplements [7].
• Phytochemical profiles indicated that C aurantium was devoid of the CYP3A4 inhibitor 6',7'-dihydroxybergamottin [8].
• In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto [8].
• Changes of lectin-binding sites on the embryonic muscle cell surface in the developing ascidian, Halocynthia aurantium [9].
• 1. Cleavage-arrested anterior animal (a4-2) blastomeres isolated from eight-cell embryos of Halocynthia aurantium differentiated into neuronal type cells expressing neuron-specific ion channels when they were treated with basic fibroblast growth factor (bFGF) [10].

Chemical compound and disease context of NSC78483

• The Seville orange extract Citrus aurantium contains m-synephrine (phenylephrine) and octopamine; it causes cardiac disturbances in animals and is used by humans for weight loss [11].
• This study was designed to evaluate the efficacy and safety of a dietary herbal supplement containing citrus aurantium and phenylephrine in the treatment of obesity [12].
• This review examines the evidence for safety and efficacy of C. aurantium and synephrine alkaloids as examined in animal studies, clinical weight loss trials, acute physiologic studies and case reports [13].
• (1999) reported that in a double-blind, placebo-controlled, randomized study the subjects receiving a combination of Citrus aurantium, caffeine and St John's Wort, lost significant amounts of total body weight while on a strict diet and exercise [14].
• Postmitochondrial fractions from marine sponges Geodia cydonium, Tethya aurantium, Verongia aerophoba and Pellina semitubulosa activate precarcinogenic aromatic amine 2-aminoanthracene, but not precarcinogenic polycyclic aromatic hydrocarbon benzo(a)pyrene, to Salmonella typhimurium TA 98 mutagens [15].

Biological context of NSC78483

• CONCLUSIONS: Botanical supplements containing C aurantium , milk thistle, or saw palmetto extracts appear to pose a minimal risk for CYP-mediated herb-drug interactions in humans [8].
• 3. Messenger RNA of the ascidian neuronal Na+ channel, TuNa I, was detected using RT-PCR in a4-2-derived partial embryos of Halocynthia aurantium as well as in the cleavage-arrested a4-2 blastomeres treated with bFGF, confirming the neural inducer activity of bFGF during ascidian embryogenesis [10].
• Five genetic linkage maps were constructed for the parents of three progenies: Citrus aurantium (A) x Poncirus trifoliata var [16].
• A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 micrograms/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium [17].
• The assessment of several parameters related to the biotransformation of mutagens/carcinogens showed that the metabolic machinery of sponge medulla cells is mainly oriented towards detoxification, with some differences depending on species (Geodia cydonium or Tethya aurantium) [18].

Anatomical context of NSC78483

• Differentiation to a similar neural phenotype occurred when isolated a4-2 blastomeres from H. aurantium embryos were treated with > 0.003% subtilisin for 60 min at the 32-cell stage of the control embryo [19].
• In the ascidians Halocynthia roretzi and H. aurantium the Ca channels in the differentiated embryo whose cleavage was arrested with cytochalasin B at the 1-cell stage and in the unfertilized egg were studied using the voltage-clamp technique [20].
• From hemocytes of the tunicate Halocynthia aurantium we purified a new antimicrobial peptide named halocidin [21].
• The effects of humidity on water permeability of astomatous, isolated cuticular membranes and leaf disks of Citrus aurantium L., Vinca major L., Prunus laurocerasus L., Hedera helix L. and Forsythia intermedia (Thunb.) Vahl. were investigated by a new method using 3H2O [22].
• Members of this cluster were specifically associated with both cortex and endosome of T. aurantium [23].

Associations of NSC78483 with other chemical compounds

• Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericarps of Citrus grandis [24].
• A simple and rapid procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of synephrine, active principle of Citrus aurantium plant, in solid and liquid dietary supplements [25].
• The method was applied to analysis of various dietary supplements promoted for aiding weight control containing, among other constituents such as ephedrine alkaloids and methylxanthines, Citrus aurantium [25].
• The purpose of this study was to set up a HPLC method to separate adrenergic amines (dl-octopamine, dl-synephrine and tyramine) and to determine their content in fruits, extracts and herbal products of Citrus aurantium L. var. amara [26].
• For the remaining seven (ginger root [Zingiber officinale], guarana [Paullinia cupana], hydroxycitric acid [Garcinia cambogia], white willow [Salix alba], Siberian ginseng [Eleutherococcus senticosus], cayenne [Capsicum annuum], and bitter orange/zhi shi [Citrus aurantium]), inadequate or negative evidence exists [27].

Gene context of NSC78483

• Also studied with the Briggs-Rauscher reaction method was the antioxidant activity of cyanidin 3-O-beta-glucopyranoside (from Citrus aurantium) in order to compare the results with those obtained by other methods [28].
• Citrus aurantium L. is commonly used as an alternative treatment for insomnia, anxiety and epilepsy [29].

Analytical, diagnostic and therapeutic context of NSC78483

• Simultaneous quantification of adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietary supplements by liquid chromatography [30].
• The chemical changes and artifact formation in daidai (Citrus aurantium L. var. Cyathifera Y. Tanaka) cold-pressed peel oil upon storage at 20, 5, and -21 degrees C for 3, 6, and 12 months were investigated using capillary gas chromatography (GC) and GC-MS [31].
• However, all four species benefited from desiccation in terms of protection during immersion in liquid nitrogen, with C. sinensis and C. aurantium showing the greatest survival (93 percent germination) after cryopreservation [32].
• In this paper, HPLC-ESI-MS technique was used to analyze the hypocholesterolemic extracts of 'Xue-Fu-Zhu-Yu decoction', a traditional Chinese medicine consisting of six crude drugs (i.e. Paeonia lactiflora, Ligusticum chuanxiong, Citrus aurantium, Carthamus tinctorius, Prunus persica and Bupleurum falcatum) [33].
• Consumption of Dietary Supplements Containing Citrus aurantium (Bitter Orange)--2004 California Behavioral Risk Factor Surveillance Survey (BRFSS) [34].

References