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MeSH Review

Attachment Sites, Microbiological

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Disease relevance of Attachment Sites, Microbiological


High impact information on Attachment Sites, Microbiological

  • Restriction fragments containing DNA from the bacterial attachment site (attB) region exhibit a different pattern of interaction with Int. In the absence of heparin, a smaller (15 bp) sequence, which includes the left half of the common core region and the common core-B arm juncture, is protected against nuclease digestion by Int protein [4].
  • Despite the different locations of the bacterial attachment sites in BBK32 compared with SfbI from S. pyogenes and FnBPA from S. aureus, an antiparallel orientation is observed for binding of the N-terminal domain of fibronectin to each of the pathogens [5].
  • Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites [6].
  • We have cloned and characterized the attachment site (att) of SopEPhi and found that its 47-bp core sequence overlaps the 3' terminus of the ssrA gene of serovar Typhimurium [7].
  • The 53,373-bp phiE125 genome contained 70 genes, an IS3 family insertion sequence (ISBt3), and an attachment site (attP) encompassing the 3' end of a proline tRNA (UGG) gene [8].

Biological context of Attachment Sites, Microbiological


Gene context of Attachment Sites, Microbiological


  1. Site-specific integration of the Streptomyces plasmid pSAM2 in Mycobacterium smegmatis. Martín, C., Mazodier, P., Mediola, M.V., Gicquel, B., Smokvina, T., Thompson, C.J., Davies, J. Mol. Microbiol. (1991) [Pubmed]
  2. Mycobacteriophage L5 integrase-mediated site-specific integration in vitro. Lee, M.H., Hatfull, G.F. J. Bacteriol. (1993) [Pubmed]
  3. Control of prophage integration and excision in bacteriophage P2: nucleotide sequences of the int gene and att sites. Yu, A., Bertani, L.E., Haggård-Ljungquist, E. Gene (1989) [Pubmed]
  4. Interaction of int protein with specific sites on lambda att DNA. Ross, W., Landy, A., Kikuchi, Y., Nash, H. Cell (1979) [Pubmed]
  5. Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes. Raibaud, S., Schwarz-Linek, U., Kim, J.H., Jenkins, H.T., Baines, E.R., Gurusiddappa, S., Höök, M., Potts, J.R. J. Biol. Chem. (2005) [Pubmed]
  6. Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites. Cantarelli, V.V., Kodama, T., Nijstad, N., Abolghait, S.K., Iida, T., Honda, T. Cell. Microbiol. (2006) [Pubmed]
  7. The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage. Pelludat, C., Mirold, S., Hardt, W.D. J. Bacteriol. (2003) [Pubmed]
  8. Burkholderia thailandensis E125 harbors a temperate bacteriophage specific for Burkholderia mallei. Woods, D.E., Jeddeloh, J.A., Fritz, D.L., DeShazer, D. J. Bacteriol. (2002) [Pubmed]
  9. Genetic organization and sequence of the region encoding integrative functions from Lactobacillus gasseri temperate bacteriophage phi adh. Fremaux, C., De Antoni, G.L., Raya, R.R., Klaenhammer, T.R. Gene (1993) [Pubmed]
  10. Transcription of a bacteriophage lambda DNA site blocks growth of Escherichia coli. Guzman, P., Rivera Chavira, B.E., Court, D.L., Gottesman, M.E., Guarneros, G. J. Bacteriol. (1990) [Pubmed]
  11. Characterization of the Micromonospora rosaria pMR2 plasmid and development of a high G+C codon optimized integrase for site-specific integration. Hosted, T.J., Wang, T., Horan, A.C. Plasmid (2005) [Pubmed]
  12. Control of effective expression of the phage phiCTX-encoded ctx gene in Pseudomonas aeruginosa by a promoter upstream of the cos site. Xiong, G., Lin, J., Oepen, P., Senerwa, D., Lutz, F. Mol. Gen. Genet. (1998) [Pubmed]
  13. Development of the Micromonospora carbonacea var. africana ATCC 39149 bacteriophage pMLP1 integrase for site-specific integration in Micromonospora spp. Alexander, D.C., Devlin, D.J., Hewitt, D.D., Horan, A.C., Hosted, T.J. Microbiology (Reading, Engl.) (2003) [Pubmed]
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