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Gene Review

CTTN  -  cortactin

Homo sapiens

Synonyms: Amplaxin, EMS1, Oncogene EMS1, Src substrate cortactin
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Disease relevance of CTTN


High impact information on CTTN


Chemical compound and disease context of CTTN


Biological context of CTTN


Anatomical context of CTTN


Associations of CTTN with chemical compounds


Physical interactions of CTTN

  • GST-cortactin interacted with WIP in an SH3-dependent manner [15].
  • BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration [22].
  • Furthermore, actin polymerization at and distribution of Arp2/3 complex as well as endogenous cortactin into the cell-leading edge mediated by S1P was disturbed [23].
  • Co-immunoprecipitation studies confirmed an association between p47phox and actin and demonstrated an interaction with the actin-binding protein cortactin [24].
  • These results provide the first evidence that a RhoGAP functionally interacts with cortactin and represents a novel determinant in the regulation of cell dynamics [22].

Co-localisations of CTTN

  • In conditionally immortalized mouse podocytes, we demonstrate that CD2AP colocalizes with cortactin and F-actin in spots of < or =0.5-microm diameter [25].

Regulatory relationships of CTTN


Other interactions of CTTN

  • Lastly, coexpression of cortactin and WIP stimulated membrane protrusions [15].
  • The Grb2 small adapter protein known to associate via its Src homology 2 domain (SH2) with the MET C-terminus, was also associated with cortactin [17].
  • These results suggest that in addition to CCND1 and EMS1, other important genes also may be target genes driving 11q13 amplification [29].
  • Taken together, cortactin is required for optimal clathrin mediated endocytosis in a dynamin directed manner [30].
  • Cortactin contains (i) a filamentous actin binding tandem repeat domain, (ii) a proline-rich SH3-binding and (iii) a SH3 domain that is common in proteins involved in signal transduction [4].

Analytical, diagnostic and therapeutic context of CTTN


  1. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Rothschild, B.L., Shim, A.H., Ammer, A.G., Kelley, L.C., Irby, K.B., Head, J.A., Chen, L., Varella-Garcia, M., Sacks, P.G., Frederick, B., Raben, D., Weed, S.A. Cancer Res. (2006) [Pubmed]
  2. Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication. Unsworth, K.E., Way, M., McNiven, M., Machesky, L., Holden, D.W. Cell. Microbiol. (2004) [Pubmed]
  3. Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Ormandy, C.J., Musgrove, E.A., Hui, R., Daly, R.J., Sutherland, R.L. Breast Cancer Res. Treat. (2003) [Pubmed]
  4. Characterization of the EMS1 gene and its product, human Cortactin. Schuuring, E., van Damme, H., Schuuring-Scholtes, E., Verhoeven, E., Michalides, R., Geelen, E., de Boer, C., Brok, H., van Buuren, V., Kluin, P. Cell Adhes. Commun. (1998) [Pubmed]
  5. Integration of signals to the Arp2/3 complex. Weaver, A.M., Young, M.E., Lee, W.L., Cooper, J.A. Curr. Opin. Cell Biol. (2003) [Pubmed]
  6. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Gomez, T.S., McCarney, S.D., Carrizosa, E., Labno, C.M., Comiskey, E.O., Nolz, J.C., Zhu, P., Freedman, B.D., Clark, M.R., Rawlings, D.J., Billadeau, D.D., Burkhardt, J.K. Immunity (2006) [Pubmed]
  7. Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Chen, X.M., Huang, B.Q., Splinter, P.L., Cao, H., Zhu, G., McNiven, M.A., LaRusso, N.F. Gastroenterology (2003) [Pubmed]
  8. Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. Bougnères, L., Girardin, S.E., Weed, S.A., Karginov, A.V., Olivo-Marin, J.C., Parsons, J.T., Sansonetti, P.J., Van Nhieu, G.T. J. Cell Biol. (2004) [Pubmed]
  9. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Bowden, E.T., Onikoyi, E., Slack, R., Myoui, A., Yoneda, T., Yamada, K.M., Mueller, S.C. Exp. Cell Res. (2006) [Pubmed]
  10. Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation. Agerer, F., Lux, S., Michel, A., Rohde, M., Ohlsen, K., Hauck, C.R. J. Cell. Sci. (2005) [Pubmed]
  11. EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival. Hui, R., Ball, J.R., Macmillan, R.D., Kenny, F.S., Prall, O.W., Campbell, D.H., Cornish, A.L., McClelland, R.A., Daly, R.J., Forbes, J.F., Blamey, R.W., Musgrove, E.A., Robertson, J.F., Nicholson, R.I., Sutherland, R.L. Oncogene (1998) [Pubmed]
  12. Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Hill, A., McFarlane, S., Mulligan, K., Gillespie, H., Draffin, J.E., Trimble, A., Ouhtit, A., Johnston, P.G., Harkin, D.P., McCormick, D., Waugh, D.J. Oncogene (2006) [Pubmed]
  13. Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation. Bourguignon, L.Y., Singleton, P.A., Diedrich, F. J. Biol. Chem. (2004) [Pubmed]
  14. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. Lynch, D.K., Winata, S.C., Lyons, R.J., Hughes, W.E., Lehrbach, G.M., Wasinger, V., Corthals, G., Cordwell, S., Daly, R.J. J. Biol. Chem. (2003) [Pubmed]
  15. Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Kinley, A.W., Weed, S.A., Weaver, A.M., Karginov, A.V., Bissonette, E., Cooper, J.A., Parsons, J.T. Curr. Biol. (2003) [Pubmed]
  16. Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits. Zhu, J., Zhou, K., Hao, J.J., Liu, J., Smith, N., Zhan, X. J. Cell. Sci. (2005) [Pubmed]
  17. Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner. Crostella, L., Lidder, S., Williams, R., Skouteris, G.G. Oncogene (2001) [Pubmed]
  18. Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. Dudek, S.M., Jacobson, J.R., Chiang, E.T., Birukov, K.G., Wang, P., Zhan, X., Garcia, J.G. J. Biol. Chem. (2004) [Pubmed]
  19. Dynamin2 and cortactin regulate actin assembly and filament organization. Schafer, D.A., Weed, S.A., Binns, D., Karginov, A.V., Parsons, J.T., Cooper, J.A. Curr. Biol. (2002) [Pubmed]
  20. Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin. Usatyuk, P.V., Romer, L.H., He, D., Parinandi, N.L., Kleinberg, M.E., Zhan, S., Jacobson, J.R., Dudek, S.M., Pendyala, S., Garcia, J.G., Natarajan, V. J. Biol. Chem. (2007) [Pubmed]
  21. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. Cantarelli, V.V., Kodama, T., Nijstad, N., Abolghait, S.K., Nada, S., Okada, M., Iida, T., Honda, T. Cell. Microbiol. (2007) [Pubmed]
  22. BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. Lua, B.L., Low, B.C. Mol. Biol. Cell (2004) [Pubmed]
  23. Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. Li, Y., Uruno, T., Haudenschild, C., Dudek, S.M., Garcia, J.G., Zhan, X. Exp. Cell Res. (2004) [Pubmed]
  24. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II. Touyz, R.M., Yao, G., Quinn, M.T., Pagano, P.J., Schiffrin, E.L. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  25. Association of CD2AP with dynamic actin on vesicles in podocytes. Welsch, T., Endlich, N., Gökce, G., Doroshenko, E., Simpson, J.C., Kriz, W., Shaw, A.S., Endlich, K. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  26. A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. Kempiak, S.J., Yamaguchi, H., Sarmiento, C., Sidani, M., Ghosh, M., Eddy, R.J., Desmarais, V., Way, M., Condeelis, J., Segall, J.E. J. Biol. Chem. (2005) [Pubmed]
  27. Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Timpson, P., Lynch, D.K., Schramek, D., Walker, F., Daly, R.J. Cancer Res. (2005) [Pubmed]
  28. CXCL12 Induces Tyrosine Phosphorylation of Cortactin, Which Plays a Role in CXC Chemokine Receptor 4-mediated Extracellular Signal-regulated Kinase Activation and Chemotaxis. Luo, C., Pan, H., Mines, M., Watson, K., Zhang, J., Fan, G.H. J. Biol. Chem. (2006) [Pubmed]
  29. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma. Huang, X., Godfrey, T.E., Gooding, W.E., McCarty, K.S., Gollin, S.M. Genes Chromosomes Cancer (2006) [Pubmed]
  30. Roles of cortactin, an actin polymerization mediator, in cell endocytosis. Chen, L., Wang, Z.W., Zhu, J.W., Zhan, X. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  31. Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice. van Rossum, A.G., van Bragt, M.P., Schuuring-Scholtes, E., van der Ploeg, J.C., van Krieken, J.H., Kluin, P.M., Schuuring, E. BMC Cancer (2006) [Pubmed]
  32. Cortactin promotes cell motility by enhancing lamellipodial persistence. Bryce, N.S., Clark, E.S., Leysath, J.L., Currie, J.D., Webb, D.J., Weaver, A.M. Curr. Biol. (2005) [Pubmed]
  33. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Schuuring, E., Verhoeven, E., Mooi, W.J., Michalides, R.J. Oncogene (1992) [Pubmed]
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