Disease relevance of Headache Disorders, Primary

• Exertional migraine, benign orgasmic cephalalgia, chronic paroxysmal hemicrania, cough headache, and "ice-pick" headache are treated with indomethacin [1].
• BACKGROUND: Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin [2].
• Eleven patients with primary thunderclap headache (TCH) were treated with oral nimodipine 30 to 60 mg every 4 hours or IV nimodipine 0.5 to 2 mg/h if the oral regimen failed or images showed cerebral vasospasm [3].
• Indomethacin-responsive headache syndromes represent a unique group of primary headache disorders characterized by a prompt and often complete response to indomethacin to the exclusion of other nonsteroidal anti-inflammatory drugs and medications usually effective in treating other primary headache disorders [4].

High impact information on Headache Disorders, Primary

• Benign cough headache is responsive to acetazolamide [5].
• Gabapentin-responsive idiopathic stabbing headache [6].
• Hypnic headache syndrome: association of the attacks with REM sleep [7].
• Spontaneous CSF leaks mimicking benign exertional headaches [8].
• Hypnic headache: rapid and long-lasting response to prednisone in two new cases [9].

Chemical compound and disease context of Headache Disorders, Primary

• Exploding head syndrome and idiopathic stabbing headache relieved by nifedipine [10].
• We believe that it is important to consider a diagnosis of hypnic headache because of the remarkable response to lithium carbonate shown by some patients with this condition [11].
• Treatment of primary headache disorders with intravenous valproate: initial outpatient experience [12].
• Nimodipine for treatment of primary thunderclap headache [3].
• Melatonin as treatment for idiopathic stabbing headache [13].

Gene context of Headache Disorders, Primary

• COX-2 inhibitor for the treatment of idiopathic stabbing headache secondary to cerebrovascular diseases [14].

References