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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Headache


High impact information on Headache

  • In support, there is a clear association between the head pain and the release of the neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminovascular system [6].
  • CSF volume depletions, whether from leak or shunt overdrainage, typically cause low CSF opening pressures, orthostatic headaches, and diffuse pachymeningeal gadolinium enhancement on MRI [7].
  • Experimental cranial pain elicited by capsaicin: a PET study [8].
  • MAIN OUTCOME MEASURES: Relief of head pain and recurrence of successfully treated headache [9].
  • INTERVENTIONS: Patients with moderate or severe head pain were randomized to receive either 1 mg of subcutaneous dihydroergotamine mesylate or 6 mg of subcutaneous sumatriptan succinate [9].

Chemical compound and disease context of Headache


Biological context of Headache


Anatomical context of Headache


Gene context of Headache

  • Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain [21].
  • The evidence supports a role for NGF related mechanisms in inflammatory vascular head pain [22].
  • In this review, we summarize the literature on the clinical features of headache in ischemic cerebrovascular disease (Part I) and elaborate upon the underlying mechanisms of the head pain (Part II--December issue) [23].
  • Hemicrania continua responds to cyclooxygenase-2 inhibitors [24].
  • Emergency department physicians, however, diagnosed only 32% of the respondents with migraine, while 59% were diagnosed as having "cephalgia" or "headache NOS" (not otherwise specified) [25].

Analytical, diagnostic and therapeutic context of Headache


  1. Posterior hypothalamic activation in paroxysmal hemicrania. Matharu, M.S., Cohen, A.S., Frackowiak, R.S., Goadsby, P.J. Ann. Neurol. (2006) [Pubmed]
  2. Hemicrania continua is not that rare. Peres, M.F., Silberstein, S.D., Nahmias, S., Shechter, A.L., Youssef, I., Rozen, T.D., Young, W.B. Neurology (2001) [Pubmed]
  3. Spontaneous intracranial hypotension with pachymeningeal enhancement on MRI. Hochman, M.S., Naidich, T.P., Kobetz, S.A., Fernandez-Maitin, A. Neurology (1992) [Pubmed]
  4. An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres. Smith, D., Hill, R.G., Edvinsson, L., Longmore, J. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  5. Verapamil-responsive hemicrania continua in a patient with episodic cluster headache. Rozen, T.D. Cephalalgia : an international journal of headache. (2006) [Pubmed]
  6. Neurobiology in primary headaches. Edvinsson, L., Uddman, R. Brain Res. Brain Res. Rev. (2005) [Pubmed]
  7. Absent headache despite CSF volume depletion (intracranial hypotension). Mokri, B., Atkinson, J.L., Piepgras, D.G. Neurology (2000) [Pubmed]
  8. Experimental cranial pain elicited by capsaicin: a PET study. May, A., Kaube, H., Büchel, C., Eichten, C., Rijntjes, M., Jüptner, M., Weiller, C., Diener, H.C. Pain (1998) [Pubmed]
  9. A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. Winner, P., Ricalde, O., Le Force, B., Saper, J., Margul, B. Arch. Neurol. (1996) [Pubmed]
  10. Benign coital cephalalgia. Differential diagnosis and treatment. Porter, M., Jankovic, J. Arch. Neurol. (1981) [Pubmed]
  11. Subjective side-effects of amitriptyline and lithium in affective disorders. Abou-Saleh, M.T., Coppen, A. The British journal of psychiatry : the journal of mental science. (1983) [Pubmed]
  12. Multiple-dose pharmacokinetics of cefprozil and its impact on intestinal flora of volunteers. Lode, H., Müller, C., Borner, K., Nord, C.E., Koeppe, P. Antimicrob. Agents Chemother. (1992) [Pubmed]
  13. Function of the peripheral serotoninergic pathways in migraine: a proposal for an experimental model. Martelletti, P., Stirparo, G., Rinaldi, C., Fusco, B.M. Cephalalgia : an international journal of headache. (1994) [Pubmed]
  14. Hemicrania continua responsive to rofecoxib. Peres, M.F., Zukerman, E. Cephalalgia : an international journal of headache. (2000) [Pubmed]
  15. Headaches due to cerebrovascular disease. Kawamura, J., Meyer, J.S. Med. Clin. North Am. (1991) [Pubmed]
  16. A comparison of the effects of human alpha calcitonin gene-related peptide and glyceryl trinitrate on regional blood velocity in man. MacDonald, N.J., Butters, L., O'Shaughnessy, D.J., Riddell, A.J., Rubin, P.C. British journal of clinical pharmacology. (1989) [Pubmed]
  17. Nerve growth factor and chronic daily headache: a potential implication for therapy. Sarchielli, P., Gallai, V. Expert review of neurotherapeutics. (2004) [Pubmed]
  18. novel Award First Prize Paper. Orthotic management of plantar pressure and pain in rheumatoid arthritis. Hodge, M.C., Bach, T.M., Carter, G.M. Clinical biomechanics (Bristol, Avon) (1999) [Pubmed]
  19. Osteomyelitis of the skull base, etiology unknown. Sie, K.C., Glenn, M.G., Hillel, A.H., Cummings, C.W. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1991) [Pubmed]
  20. Streptococcus acidominimus infection in a child causing Gradenigo syndrome. Finkelstein, Y., Marcus, N., Mosseri, R., Bar-Sever, Z., Garty, B.Z. Int. J. Pediatr. Otorhinolaryngol. (2003) [Pubmed]
  21. Glial cell line-derived neurotrophic factor and somatostatin levels in cerebrospinal fluid of patients affected by chronic migraine and fibromyalgia. Sarchielli, P., Alberti, A., Candeliere, A., Floridi, A., Capocchi, G., Calabresi, P. Cephalalgia : an international journal of headache. (2006) [Pubmed]
  22. Decreased CGRP, but preserved Trk A immunoreactivity in nerve fibres in inflamed human superficial temporal arteries. Saldanha, G., Hongo, J., Plant, G., Acheson, J., Levy, I., Anand, P. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  23. Headache in ischemic cerebrovascular disease. Part I: Clinical features. Mitsias, P., Ramadan, N.M. Cephalalgia : an international journal of headache. (1992) [Pubmed]
  24. Hemicrania continua responds to cyclooxygenase-2 inhibitors. Peres, M.F., Silberstein, S.D. Headache. (2002) [Pubmed]
  25. Treatment of primary headache in the emergency department. Blumenthal, H.J., Weisz, M.A., Kelly, K.M., Mayer, R.L., Blonsky, J. Headache. (2003) [Pubmed]
  26. Treatment of primary headache disorders with intravenous valproate: initial outpatient experience. Stillman, M.J., Zajac, D., Rybicki, L.A. Headache. (2004) [Pubmed]
  27. Effect of sumatriptan in different models of pain in rats. Ottani, A., Ferraris, E., Giuliani, D., Mioni, C., Bertolini, A., Sternieri, E., Ferrari, A. Eur. J. Pharmacol. (2004) [Pubmed]
  28. Self-administration of parenteral ketorolac tromethamine for head pain. Turkewitz, L.J., Casaly, J.S., Dawson, G.A., Wirth, O., Hurst, R.J., Gillette, P.L. Headache. (1992) [Pubmed]
  29. Early epidural blood patch in spontaneous intracranial hypotension. Berroir, S., Loisel, B., Ducros, A., Boukobza, M., Tzourio, C., Valade, D., Bousser, M.G. Neurology (2004) [Pubmed]
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