Disease relevance of Paroxysmal Hemicrania

• Indomethacin has consistently been proven to provide complete and sustained relief of symptoms in hemicrania continua (HC) and chronic paroxysmal hemicrania (CPH), but is not devoid of side-effects [1].
• In eight patients with chronic paroxysmal hemicrania (CPH), forehead sweating was measured after various provocation tests-body heating, exercise, and subcutaneous pilocarpine administration (0.1 mg/kg body weight) [2].
• The chronic paroxysmal hemicrania (CPH) was controlled with indomethacin and the trigeminal neuralgia with a glycerol blockade [3].
• Of the various drugs used in the treatment of headache, lithium is an accepted treatment for cluster headache, and indomethacin is the drug of choice for the associated condition chronic paroxysmal hemicrania [4].
• When the otalgia is paroxysmal, unilateral, severe, frequent, and associated with autonomic signs, one should consider the diagnosis of chronic paroxysmal hemicrania, especially because of the prompt response to indomethacin [5].

High impact information on Paroxysmal Hemicrania

• Responsiveness to celecoxib in chronic paroxysmal hemicrania [6].
• No changes of ERP latencies and amplitudes could be observed in chronic paroxysmal hemicrania [7].
• There are a group of headaches, such as paroxysmal hemicrania and hemicrana continua , which have a curious and a very robust response to indomethacin [8].
• Chronic paroxysmal hemicrania IV: "REM sleep locked" nocturnal headache attacks [9].
• Seasonal episodic paroxysmal hemicrania responding to cyclooxygenase-2 inhibitors [10].

Chemical compound and disease context of Paroxysmal Hemicrania

• A case of chronic paroxysmal hemicrania responding to subcutaneous sumatriptan [11].
• Rofecoxib for the treatment of chronic paroxysmal hemicrania [12].
• Pupillometric studies were carried out in eight patients with chronic paroxysmal hemicrania (CPH) and in age- and sex-matched controls in the basal condition and after instillation of 2% tyramine (CPH, n = 5; controls, n = 17), 1% OH-amphetamine (CPH, n = 6; controls, n = 12), and 1% phenylephrine (CPH, n = 6; controls, n = 17) [13].
• Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy [14].
• The trial results, in accordance with a review of the literature, suggest that acetylsalicylic acid (and probably naproxen and diclofenac) and verapamil are the most effective drugs of second choice in chronic paroxysmal hemicrania [15].

Gene context of Paroxysmal Hemicrania

• A 62-year-old man with ankylosing spondylitis and with a 3-year history of chronic paroxysmal hemicrania is presented [16].

References