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MeSH Review

Spondylitis, Ankylosing

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Disease relevance of Spondylitis, Ankylosing


High impact information on Spondylitis, Ankylosing

  • The primary outcome was a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) improvement > or =50% after 2 years of etanercept therapy compared with the baseline value of the study [6].
  • Validation exercise of the Ankylosing Spondylitis Assessment Study (ASAS) group response criteria in ankylosing spondylitis patients treated with biologics [7].
  • RESULTS: In the group of AS patients not treated with biologics, both M-CSF and MMP-3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other [8].
  • BASDAI, Bath Ankylosing Spondylitis Functional Index (BASFI), ESR, CRP and ankylosing spondylitis assessment (ASAS) criteria were used to assess response [9].
  • Assessment of RA was by the RA Disease Activity Index (RADAI), the 44 joint count, and the Health Assessment Questionnaire; assessment of AS by the Bath Ankylosing Spondylitis Activity Index (BASDAI), the Dougados Functional and Articular Index, and a night pain index [10].

Chemical compound and disease context of Spondylitis, Ankylosing


Anatomical context of Spondylitis, Ankylosing

  • Disease activity in SpA patients was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and laboratory parameters of inflammation [erythrocyte sedimentation rate (ESR) and C-reactive protein level (CRP)] [12].
  • In addition, the percentage of CD4(+)/CCR4(+) T cells showed significant positive correlations with the Bath ankylosing spondylitis disease activity index (BASDAI) in AS and with the SLE disease activity index (SLEDAI) in untreated SLE [13].

Gene context of Spondylitis, Ankylosing


Analytical, diagnostic and therapeutic context of Spondylitis, Ankylosing

  • METHODS: Because of clinical and radiographic signs of cord compression, 15 patients with rheumatoid arthritis (including one with Bechterew's disease) and severe involvement of the cervical spine underwent decompressive laminectomy without fusion performed on one or more levels [17].


  1. ICF based comparison of disease specific instruments measuring physical functional ability in ankylosing spondylitis. Sigl, T., Cieza, A., van der Heijde, D., Stucki, G. Ann. Rheum. Dis. (2005) [Pubmed]
  2. Baseline factors that influence ASAS 20 response in patients with ankylosing spondylitis treated with etanercept. Davis, J.C., Van der Heijde, D.M., Dougados, M., Braun, J., Cush, J.J., Clegg, D.O., Inman, R.D., de Vries, T., Tsuji, W.H. J. Rheumatol. (2005) [Pubmed]
  3. Juvenile onset ankylosing spondylitis (JAS) has less severe spinal disease course than adult onset ankylosing spondylitis (AAS): clinical comparison between JAS and AAS in Korea. Baek, H.J., Shin, K.C., Lee, Y.J., Kang, S.W., Lee, E.B., Yoo, C.D., Song, Y.W. J. Rheumatol. (2002) [Pubmed]
  4. Nabumetone: a "nonacidic" nonsteroidal antiinflammatory drug. Dahl, S.L. The Annals of pharmacotherapy. (1993) [Pubmed]
  5. Chemistry and pharmacology of naproxen. Dorfman, R.I. Arzneimittel-Forschung. (1975) [Pubmed]
  6. Outcome of patients with active ankylosing spondylitis after two years of therapy with etanercept: clinical and magnetic resonance imaging data. Baraliakos, X., Brandt, J., Listing, J., Haibel, H., Sörensen, H., Rudwaleit, M., Sieper, J., Braun, J. Arthritis Rheum. (2005) [Pubmed]
  7. Validation exercise of the Ankylosing Spondylitis Assessment Study (ASAS) group response criteria in ankylosing spondylitis patients treated with biologics. Stone, M.A., Inman, R.D., Wright, J.G., Maetzel, A. Arthritis Rheum. (2004) [Pubmed]
  8. Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis. Yang, C., Gu, J., Rihl, M., Baeten, D., Huang, F., Zhao, M., Zhang, H., Maksymowych, W.P., De Keyser, F., Veys, E.M., Yu, D.T. Arthritis Rheum. (2004) [Pubmed]
  9. Effectiveness of reducing infliximab dose interval in non-responder patients with refractory spondyloarthropathies. An open extension of a multicentre study. Collantes-Estevez, E., Muñoz-Villanueva, M.C., Zarco, P., Torre-Alonso, J.C., Gratacós, J., González, C., Sanmartí, R., Cañete, J.D. Rheumatology (Oxford, England) (2005) [Pubmed]
  10. A prospective study of pregnant patients with rheumatoid arthritis and ankylosing spondylitis using validated clinical instruments. Østensen, M., Fuhrer, L., Mathieu, R., Seitz, M., Villiger, P.M. Ann. Rheum. Dis. (2004) [Pubmed]
  11. No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Haibel, H., Brandt, H.C., Song, I.H., Brandt, A., Listing, J., Rudwaleit, M., Sieper, J. Ann. Rheum. Dis. (2007) [Pubmed]
  12. High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies. Drouart, M., Saas, P., Billot, M., Cedoz, J.P., Tiberghien, P., Wendling, D., Toussirot, E. Clin. Exp. Immunol. (2003) [Pubmed]
  13. Increased CCR4 expression on circulating CD4(+) T cells in ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus. Yang, P.T., Kasai, H., Zhao, L.J., Xiao, W.G., Tanabe, F., Ito, M. Clin. Exp. Immunol. (2004) [Pubmed]
  14. Neuroendocrine immune features of pediatric inflammatory rheumatic diseases. Chikanza, I.C. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  15. Bath ankylosing spondylitis functional index (BASFI) evaluation of postoperative patients with OPLL. Mori, K., Hukuda, S., Katsuura, A., Saruhashi, Y., Matsusue, Y. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2004) [Pubmed]
  16. Radioisotope binding capacity of serum in folic acid, vitamin B12 and ferritin in haematologic and rheumatologic patients. Rinhelhann, B., Revicky, A., Arvai, I., Megyeri, A., Gömör, B., Jósfay, L., Csák, E. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1980) [Pubmed]
  17. Cervical laminectomy without fusion in patients with rheumatoid arthritis. Christensson, D., Säveland, H., Zygmunt, S., Jonsson, K., Rydholm, U. J. Neurosurg. (1999) [Pubmed]
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