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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Laminectomy

  • We present seven patients with multilevel cervical spondylotic myelopathy and superimposed midline soft disc herniation who were treated by decompressive laminectomies of the spondylotic segments followed by transdural excision of the anteriorly located disc extrusion [1].
  • Outcome after laminectomy for lumbar spinal stenosis. Part I: Clinical correlations [2].
  • INTERVENTION: The patient was treated with a laminectomy at the level of stenosis accompanied by posterior instrumentation and fusion from C5 to T3 [3].
  • This is a report of a double-bind controlled trial to test the hypothesis that peroperative local infiltration of the wound of lumbar laminectomy with bupivacaine produces a significant reduction in postoperative back pain [4].
  • We report a case of anaphylaxis caused by irrigation with a bacitracin solution during lumbar laminectomy [5].

Psychiatry related information on Laminectomy

  • Twenty-five postoperative lumbar laminectomy and diskectomy patients were administered the MMPI and evaluated by physical examination which included the Burns' Bench Test. In this test the patient is asked to kneel on a bench with knees and hips flexed and place his fingers on the floor [6].

High impact information on Laminectomy

  • Free fatty acid (FFA), diacylglycerol (acyl2Gro), icosanoid, phospholipid, and cholesterol levels were measured in samples of cat spinal cord (L2) that were frozen in situ with vertebrae intact, at various times after laminectomy, and at various times after laminectomy with compression trauma to the spinal cord [7].
  • Three- to 7-week-old postnatal and adult (>10-week-old) rats were anesthetized and laminectomy was performed between C5 and Th1 to expose the dorsal surface of the cervical spinal cord [8].
  • The region of the dorsal surface of C2 spinal cord was exposed by a laminectomy and an electrode placed for recording evoked activity from sinus stimulation and spontaneous activity of the same cells [9].
  • The p9 and p11 positivities fused after laminectomy, suggesting that conductance change at the root entry to the bony spinal canal separates these components in the noncephalic reference recording [10].
  • One patient received high-dose dexamethasone after laminectomy for diagnostic biopsy; otherwise, dexamethasone was used only as an anti-emetic prior to chemotherapy [11].

Chemical compound and disease context of Laminectomy


Biological context of Laminectomy


Anatomical context of Laminectomy


Associations of Laminectomy with chemical compounds

  • Laminectomy for decompression and diagnosis, administration of antischistosomal medications, and high-dose oral prednisone early in the illness are recommended [24].
  • Uninjured surgical (laminectomy) control animals showed modest but significant declines in aspartate and glutamate levels, but not in other amino acids, at all time points [25].
  • Twenty-two patients who had undergone at least one prior laminectomy, who were still symptomatic, were randomized to receive 50 mg of lidocaine epidurally with: (a) 75 mg triamcinolone diacetate (TR); or (b) 8 mg of preservative-free morphine (MP); or (c) both (TR and MP), at 1 month intervals for 3 consecutive months [26].
  • Bone scans using Tc-99m diphosphonate were found to become abnormal within 2 weeks after laminectomy in less than half of patients regardless of the extent of the operation [27].
  • In a second series of experiments the effect of SCS, applied acutely via a laminectomy, on the early component (latency: 8-12 msec) of the flexor reflex was studied [28].

Gene context of Laminectomy


Analytical, diagnostic and therapeutic context of Laminectomy


  1. Transdural approach to the anterior spinal canal in patients with cervical spondylotic myelopathy and superimposed central soft disc herniation. Fox, M.W., Onofrio, B.M. Neurosurgery (1994) [Pubmed]
  2. Outcome after laminectomy for lumbar spinal stenosis. Part I: Clinical correlations. Tuite, G.F., Stern, J.D., Doran, S.E., Papadopoulos, S.M., McGillicuddy, J.E., Oyedijo, D.I., Grube, S.V., Lundquist, C., Gilmer, H.S., Schork, M.A. J. Neurosurg. (1994) [Pubmed]
  3. Adjacent segment disease: an uncommon complication after cervical expansile laminoplasty: case report. Wang, M.Y., Green, B.A., Vitarbo, E., Levi, A.D. Neurosurgery (2003) [Pubmed]
  4. Bupivacaine infiltration after lumbar laminectomy. Local infiltration in the control of early postoperative lumbar laminectomy pain. Teddy, P.J., Fabinyi, G.C., Kerr, J.H., Briggs, M. Anaesthesia. (1981) [Pubmed]
  5. Intraoperative anaphylaxis after irrigation with bacitracin: case report. Netland, P.A., Baumgartner, J.E., Andrews, B.T. Neurosurgery (1987) [Pubmed]
  6. The Burns' test in low back pain: correlation with the hysterical personality. Evanski, P.M., Carver, D., Nehemkis, A., Waugh, T.R. Clin. Orthop. Relat. Res. (1979) [Pubmed]
  7. Membrane lipid changes in laminectomized and traumatized cat spinal cord. Demediuk, P., Saunders, R.D., Anderson, D.K., Means, E.D., Horrocks, L.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  8. Postnatal changes in intrinsic optical responses to peripheral nerve stimulation in the in vivo rat spinal cord. Sasaki, S., Sato, K., Shinomiya, K., Momose-Sato, Y. Neuroimage (2003) [Pubmed]
  9. Microiontophoretic application of serotonin (5HT)1B/1D agonists inhibits trigeminal cell firing in the cat. Storer, R.J., Goadsby, P.J. Brain (1997) [Pubmed]
  10. Origin of short-latency somatosensory evoked potentials to median nerve stimulation in the cat. Comparison of the recording montages and effect of laminectomy. Kaji, R., Tanaka, R., Kawaguchi, S., McCormick, F., Kameyama, M. Brain (1986) [Pubmed]
  11. Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. Wong, E.T., Portlock, C.S., O'Brien, J.P., DeAngelis, L.M. Neurology (1996) [Pubmed]
  12. Contrast between scar and recurrent herniated disk on contrast-enhanced MR images. Haughton, V., Schreibman, K., De Smet, A. AJNR. American journal of neuroradiology. (2002) [Pubmed]
  13. Occipitoatlantoaxial fusion utilizing a rectangular rod. Sakou, T., Kawaida, H., Morizono, Y., Matsunaga, S., Fielding, J.W. Clin. Orthop. Relat. Res. (1989) [Pubmed]
  14. Cervical cord compression in hereditary multiple exostoses. Eder, H.G., Oberbauer, R.W., Ranner, G. Journal of neurosurgical sciences. (1993) [Pubmed]
  15. Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma. Adamson, D.C., Cummings, T.J., Friedman, A.H. Clin. Neuropathol. (2004) [Pubmed]
  16. Postoperative highcervical quadriplegia after transoral biopsy of a paravertebral tuberculous abscess with epidural extension: complete resolution after decompressive laminectomy and high-dose methylprednisolone. Knutti, O., Kaech, D.L. Acta neurochirurgica. (1997) [Pubmed]
  17. Postlaminectomy adhesion of the cauda equina. Changes of postoperative vascular permeability of the equina in rats. Nakano, M., Matsui, H., Miaki, K., Yamagami, T., Tsuji, H. Spine. (1997) [Pubmed]
  18. Postoperative instability of cervical OPLL and cervical radiculomyelopathy. Kamioka, Y., Yamamoto, H., Tani, T., Ishida, K., Sawamoto, T. Spine. (1989) [Pubmed]
  19. Syringomyelia associated with Hajdu-Cheney syndrome: case report. Tanimoto, A., Tamaki, N., Nagashima, T., Nakamura, M. Neurosurgery (1996) [Pubmed]
  20. Tailored operative technique for Chiari type I malformation using intraoperative color Doppler ultrasonography. Milhorat, T.H., Bolognese, P.A. Neurosurgery (2003) [Pubmed]
  21. Cervical laminectomy without fusion in patients with rheumatoid arthritis. Christensson, D., Säveland, H., Zygmunt, S., Jonsson, K., Rydholm, U. J. Neurosurg. (1999) [Pubmed]
  22. Occipitocervical fusion with a five-millimeter malleable rod and segmental fixation. Fehlings, M.G., Errico, T., Cooper, P., Benjamin, V., DiBartolo, T. Neurosurgery (1993) [Pubmed]
  23. Peripheral nerve grafts promoting central nervous system regeneration after spinal cord injury in the primate. Levi, A.D., Dancausse, H., Li, X., Duncan, S., Horkey, L., Oliviera, M. J. Neurosurg. (2002) [Pubmed]
  24. Schistosomiasis of the spinal cord. Lechtenberg, R., Vaida, G.A. Neurology (1977) [Pubmed]
  25. Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord. Demediuk, P., Daly, M.P., Faden, A.I. J. Neurochem. (1989) [Pubmed]
  26. Epidural steroids, epidural morphine and epidural steroids combined with morphine in the treatment of post-laminectomy syndrome. Rocco, A.G., Frank, E., Kaul, A.F., Lipson, S.J., Gallo, J.P. Pain (1989) [Pubmed]
  27. Laminectomy: effects on postoperative technetium and gallium scintigraphy. Silberstein, E.B., Schneider, H.J., Khodadad, G., DeVries, D., Rauf, G.C., Noll, R. Radiology. (1984) [Pubmed]
  28. Spinal cord stimulation in animal models of mononeuropathy: effects on the withdrawal response and the flexor reflex. Meyerson, B.A., Ren, B., Herregodts, P., Linderoth, B. Pain (1995) [Pubmed]
  29. Tuberculoma of the conus medullaris: case report. Türeyen, K. Neurosurgery (2002) [Pubmed]
  30. Transient paraparesis after laminectomy for thoracic ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum. Yamazaki, M., Koda, M., Okawa, A., Aiba, A. Spinal Cord (2006) [Pubmed]
  31. Spinal deformity and instability after multilevel cervical laminectomy. Mikawa, Y., Shikata, J., Yamamuro, T. Spine. (1987) [Pubmed]
  32. Altered immunoreactivity for glial fibrillary acidic protein in astrocytes within 1 h after cervical spinal cord injury. Hadley, S.D., Goshgarian, H.G. Exp. Neurol. (1997) [Pubmed]
  33. Increase of oligodendrocyte progenitor cells after spinal cord injury. Ishii, K., Toda, M., Nakai, Y., Asou, H., Watanabe, M., Nakamura, M., Yato, Y., Fujimura, Y., Kawakami, Y., Toyama, Y., Uyemura, K. J. Neurosci. Res. (2001) [Pubmed]
  34. Trigeminovascular nociceptive transmission involves N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors. Storer, R.J., Goadsby, P.J. Neuroscience (1999) [Pubmed]
  35. Spinal epidural metastasis: implications for spinal analgesia to treat "refractory" cancer pain. Appelgren, L., Nordborg, C., Sjöberg, M., Karlsson, P.A., Nitescu, P., Curelaru, I. Journal of pain and symptom management. (1997) [Pubmed]
  36. Changes in ornithine decarboxylase activity and putrescine concentrations after spinal cord compression injury in the rat. Mautes, A.E., Paschen, W., Röhn, G., Nacimiento, A.C. Neurosci. Lett. (1999) [Pubmed]
  37. Intrathecal acetylsalicylic acid and indomethacin are not analgesic for a supramaximal stimulus. Antognini, J.F. Anesth. Analg. (1993) [Pubmed]
  38. High thoracic midline dorsal column myelotomy for severe visceral pain due to advanced stomach cancer. Kim, Y.S., Kwon, S.J. Neurosurgery (2000) [Pubmed]
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