Gene Review:
MMP3 - matrix metallopeptidase 3 (stromelysin 1,...
Homo sapiens
Synonyms:
CHDS6, MMP-3, Matrix metalloproteinase-3, SL-1, STMY, ...
Savaraj,
Wei,
Unate,
Liu,
Wu,
Wangpaichitr,
Xia,
Xu,
Hu,
Tien Kuo,
Krippl,
Langsenlehner,
Renner,
Yazdani-Biuki,
Köppel,
Leithner,
Wascher,
Paulweber,
Samonigg,
Ye,
Sakai,
Corps,
Harrall,
Curry,
Fenwick,
Hazleman,
Riley,
Matter,
Schudok,
Elshorst,
Jacobs,
Saxena,
Kogler,
Pawluczyk,
Patel,
Harris,
Saarela,
Lehtimäki,
Rinne,
Hervonen,
Jylhä,
Röyttä,
Ahonen,
Mattila,
Tetlow,
Woolley,
Keyszer,
Lambiri,
Keysser,
Keysser,
Nagel,
Burmester,
Jung,
Kane,
Gogarty,
O'leary,
Silva,
Bermingham,
Bresnihan,
Fitzgerald,
Bailey,
Davies,
Young,
Hullin,
Seddon,
Lijnen,
Arza,
Van Hoef,
Collen,
Declerck,
Zhang,
Jin,
Fang,
Li,
Wang,
Guo,
Wang,
Wang,
Wen,
Wei,
Kuang,
Dong,
- Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians. Traurig, M.T., Permana, P.A., Nair, S., Kobes, S., Bogardus, C., Baier, L.J. Diabetes (2006)
- The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer. Krippl, P., Langsenlehner, U., Renner, W., Yazdani-Biuki, B., Köppel, H., Leithner, A., Wascher, T.C., Paulweber, B., Samonigg, H. Clin. Cancer Res. (2004)
- Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma. Blons, H., Gad, S., Zinzindohoué, F., Manière, I., Beauregard, J., Tregouet, D., Brasnu, D., Beaune, P., Laccourreye, O., Laurent-Puig, P. Clin. Cancer Res. (2004)
- The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma. Zhang, J., Jin, X., Fang, S., Li, Y., Wang, R., Guo, W., Wang, N., Wang, Y., Wen, D., Wei, L., Kuang, G., Dong, Z. Carcinogenesis (2004)
- Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Ye, S. Cardiovasc. Res. (2006)
- Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. Pöllänen, P.J., Lehtimäki, T., Mikkelsson, J., Ilveskoski, E., Kunnas, T., Perola, M., Penttilä, A., Mattila, K.M., Nikkari, S.T., Syrjäkoski, K., Karhunen, P.J. Atherosclerosis (2005)
- Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns. Saarela, M.S., Lehtimäki, T., Rinne, J.O., Hervonen, A., Jylhä, M., Röyttä, M., Ahonen, J.P., Mattila, K.M. Neurosci. Lett. (2004)
- Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells. Savaraj, N., Wei, Y., Unate, H., Liu, P.M., Wu, C.J., Wangpaichitr, M., Xia, D., Xu, H.J., Hu, S.X., Tien Kuo, M. Free Radic. Res. (2005)
- A potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sickness. Bailey, D.M., Davies, B., Young, I.S., Hullin, D.A., Seddon, P.S. Aviation, space, and environmental medicine. (2001)
- The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Sternlicht, M.D., Lochter, A., Sympson, C.J., Huey, B., Rougier, J.P., Gray, J.W., Pinkel, D., Bissell, M.J., Werb, Z. Cell (1999)
- TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Kerr, L.D., Miller, D.B., Matrisian, L.M. Cell (1990)
- Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Gomis-Rüth, F.X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G.P., Bartunik, H., Bode, W. Nature (1997)
- Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Hahm, E.R., Gho, Y.S., Park, S., Park, C., Kim, K.W., Yang, C.H. Biochem. Biophys. Res. Commun. (2004)
- Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro. Tetlow, L.C., Woolley, D.E. Ann. Rheum. Dis. (2002)
- Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. Fang, S., Jin, X., Wang, R., Li, Y., Guo, W., Wang, N., Wang, Y., Wen, D., Wei, L., Zhang, J. Carcinogenesis (2005)
- Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Corps, A.N., Harrall, R.L., Curry, V.A., Fenwick, S.A., Hazleman, B.L., Riley, G.P. Arthritis Rheum. (2002)
- Genotypes associated with myocardial infarction risk are more common in African Americans than in European Americans. Lanfear, D.E., Marsh, S., Cresci, S., Shannon, W.D., Spertus, J.A., McLeod, H.L. J. Am. Coll. Cardiol. (2004)
- Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex. Butticè, G., Duterque-Coquillaud, M., Basuyaux, J.P., Carrère, S., Kurkinen, M., Stéhelin, D. Oncogene (1996)
- The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. Humphries, S., Bauters, C., Meirhaeghe, A., Luong, L., Bertrand, M., Amouyel, P. Eur. Heart J. (2002)
- Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. Bramhall, S.R., Stamp, G.W., Dunn, J., Lemoine, N.R., Neoptolemos, J.P. Br. J. Cancer (1996)
- Interleukin 1 beta and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint. Kubota, E., Imamura, H., Kubota, T., Shibata, T., Murakami, K. J. Oral Maxillofac. Surg. (1997)
- Immunohistochemical expression of matrix metalloproteinases in bile duct cancer tissue. Sakai, T. The Kurume medical journal. (2004)
- Interleukin-6 involvement in brain arteriovenous malformations. Chen, Y., Pawlikowska, L., Yao, J.S., Shen, F., Zhai, W., Achrol, A.S., Lawton, M.T., Kwok, P.Y., Yang, G.Y., Young, W.L. Ann. Neurol. (2006)
- The role of the {alpha}-1 adrenoceptor in modulating human mesangial cell matrix production. Pawluczyk, I.Z., Patel, S.R., Harris, K.P. Nephrol. Dial. Transplant. (2006)
- Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. Okada, Y., Gonoji, Y., Naka, K., Tomita, K., Nakanishi, I., Iwata, K., Yamashita, K., Hayakawa, T. J. Biol. Chem. (1992)
- Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest. Manicourt, D.H., Poilvache, P., Nzeusseu, A., van Egeren, A., Devogelaer, J.P., Lenz, M.E., Thonar, E.J. Arthritis Rheum. (1999)
- Matrix metalloproteinases, but not cathepsins B, H, and L or their inhibitors in peripheral blood of patients with rheumatoid arthritis are potentially useful markers of disease activity. Keyszer, G., Lambiri, I., Keysser, M., Keysser, C., Nagel, R., Burmester, G.R., Jung, K. Zeitschrift für Rheumatologie. (1998)
- Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase. Itoh, Y., Nagase, H. J. Biol. Chem. (1995)
- Prostromelysin-1 (proMMP-3) stimulates plasminogen activation by tissue-type plasminogen activator. Arza, B., Hoylaerts, M.F., Félez, J., Collen, D., Lijnen, H.R. Eur. J. Biochem. (2000)
- QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands. Matter, H., Schudok, M., Elshorst, B., Jacobs, D.M., Saxena, K., Kogler, H. Bioorg. Med. Chem. Lett. (2005)
- Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3). Lijnen, H.R., Arza, B., Van Hoef, B., Collen, D., Declerck, P.J. J. Biol. Chem. (2000)
- Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. Matsuno, H., Yudoh, K., Watanabe, Y., Nakazawa, F., Aono, H., Kimura, T. J. Rheumatol. (2001)
- Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3. Fowlkes, J.L., Serra, D.M. J. Biol. Chem. (1996)
- Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. Ogata, Y., Enghild, J.J., Nagase, H. J. Biol. Chem. (1992)
- Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Dreier, R., Grässel, S., Fuchs, S., Schaumburger, J., Bruckner, P. Exp. Cell Res. (2004)
- Increased matrix metalloproteinases as possible cause of osseoarticular tissue destruction in long-term haemodialysis and beta 2-microglobulin amyloidosis. Ohashi, K., Kawai, R., Hara, M., Okada, Y., Tachibana, S., Ogura, Y. Virchows Arch. (1996)
- Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T., Nakamura, T. Arthritis Rheum. (2004)
- Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture? Schönbeck, U., Mach, F., Sukhova, G.K., Murphy, C., Bonnefoy, J.Y., Fabunmi, R.P., Libby, P. Circ. Res. (1997)
- Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors. Morán, A., Iniesta, P., de Juan, C., González-Quevedo, R., Sánchez-Pernaute, A., Díaz-Rubio, E., Ramón y Cajal, S., Torres, A., Balibrea, J.L., Benito, M. Cancer Res. (2002)
- Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). Nagase, H., Fields, C.G., Fields, G.B. J. Biol. Chem. (1994)
- Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation. Manicourt, D.H., Fujimoto, N., Obata, K., Thonar, E.J. Arthritis Rheum. (1995)
- Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Yoon, S., Tromp, G., Vongpunsawad, S., Ronkainen, A., Juvonen, T., Kuivaniemi, H. Biochem. Biophys. Res. Commun. (1999)
- Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma. Zinzindohoué, F., Blons, H., Hans, S., Loriot, M.A., Houllier, A.M., Brasnu, D., Laccourreye, O., Tregouet, D.A., Stucker, I., Laurent-Puig, P. Anticancer Res. (2004)
- Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Kane, D., Gogarty, M., O'leary, J., Silva, I., Bermingham, N., Bresnihan, B., Fitzgerald, O. Arthritis Rheum. (2004)