Disease relevance of Spinal Diseases

• The recent introduction of tumor necrosis factor (TNF) blockers in the treatment of spondyloarthritis has offered the most hope in not only relieving symptoms and signs of both peripheral arthritis and enthesitis but also spinal disease, which often has been refractory to other agents [1].
• We have developed a transgenic model of the polyglutamine disease spinal and bulbar muscular atrophy (SBMA), an adult-onset, slowly progressive motor neuron disease caused by polyglutamine expansion in the androgen receptor (AR) [2].

Psychiatry related information on Spinal Diseases

• RESULTS: The PLMD and control groups were similar in the prevalence of insomnia, hypersomnia, diabetes, peripheral neurologic disorders, anemia, spinal disease, antidepressant medication use, smoking, caffeine intake, and leg pain [3].

High impact information on Spinal Diseases

• These results indicate excellent safety and efficacy for use of gadoteridol in children with suspected intracranial or spinal disease [4].
• Our data suggest that, clinically and radiographically, AAS patients with PJD have a less severe spinal disease course than those without PJD [5].
• On stereoscopic examination of the lumbar spines of 6 patients with rheumatoid arthritis and spinal disease we found typical rheumatoid erosions in the apophyseal joints [6].
• Epidural infusion pressure in degenerative spinal disease before and after epidural steroid therapy [7].
• Pre-existing degenerative spinal disease was found in 50% of patients [8].

Chemical compound and disease context of Spinal Diseases

• Of a total of 580 patients suffering from expanding spinal disease, 15 cases of intramedullary lesions were dealt with by the use of the CO2 laser [9].
• This pilot study represents a long-term evaluation of a treatment regimen consisting of intrathecal morphine admixed with bupivacaine, clonidine, or midazolam in patients with chronic nonmalignant back and leg pain due to degenerative lumbar spinal disease [10].
• Gadolinium-DTPA in spinal disease [11].
• Gadolinium contrast agents represent one of the most important advances in MR imaging of spinal disease [12].
• Ligamenta flava obtained from 24 patients who had undergone surgery for degenerative spinal diseases were investigated regarding the histopathology of hydroxyapatite crystal depositions [13].

Anatomical context of Spinal Diseases

• We studied total nitric oxide (nitrite + nitrate) (NO) levels in cerebrospinal fluid (CSF) of chronic spinal diseases in nonsmokers (133 patients: 76 men and 57 women; mean age, 63 years; range, 15-92 years) by the Griess method to clarify the role of NO in different spinal diseases [14].

Gene context of Spinal Diseases

• RESULTS: Five clinical trials with a total of 338 patients and comparing the effect on pain of radon baths (three trials) or radon speleotherapy (two trials) with control intervention in degenerative spinal disease (two trials), rheumatoid arthritis (one trial) and ankylosing spondylitis (two trials) met the inclusion criteria [15].
• Patients lacking both B27 and peripheral arthritis did not have sacroiliitis and only in one case showed evidence of spinal disease (0.7%) [16].
• BACKGROUND: More than three decades of research involving thousands of scientists and academicians throughout the world have led to the clinical use of recombinant bone morphogenetic proteins for the treatment of spinal disease [17].
• CDH (Cotrel-Dubousset-Hopf) instrumentation was developed with the aim of improving stability in ventral operation procedure and facilitating treatment of all anterior spinal diseases [18].

References