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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Suppression of metastasis by thymidine phosphorylase inhibitor.

We developed a novel inhibitor of thymidine phosphorylase ( TP), 5-chloro-6-[1-(2-iminopyrrolidinyl) methyl] uracil hydrochloride ( TPI), that is about 1000-fold more active than 6-amino-5-chlorouracil, one of the most potent TP inhibitors. TPI inhibited the high chemotactic motility and basement membrane invasion of KB/ TP cells, a TP-positive clone transfected with Rous sarcoma virus (RSV)/TP, to the levels seen in KB/CV cells, a control clone transfected with RSV. In nude mice, oral administration of TPI suppressed not only macroscopic liver metastases of highly metastatic KB/ TP cells but also the level of human beta-globin as a molecular marker of micrometastases in the livers of the mice. These findings demonstrate that TP plays a key role in the invasiveness and metastasis of TP- expressing solid tumors and suggest that TPI might be a novel antimetastatic agent for blood-borne metastasis.[1]


  1. Suppression of metastasis by thymidine phosphorylase inhibitor. Takao, S., Akiyama, S.I., Nakajo, A., Yoh, H., Kitazono, M., Natsugoe, S., Miyadera, K., Fukushima, M., Yamada, Y., Aikou, T. Cancer Res. (2000) [Pubmed]
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