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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.

Immature dendritic cells are among the first cells infected by retroviruses after mucosal exposure. We explored the effects of human immunodeficiency virus-1 (HIV-1) and its Tat transactivator on these primary antigen-presenting cells using DNA microarray analysis and functional assays. We found that HIV-1 infection or Tat expression induces interferon (IFN)-responsive gene expression in immature human dendritic cells without inducing maturation. Among the induced gene products are chemokines that recruit activated T cells and macrophages, the ultimate target cells for the virus. Dendritic cells in the lymph nodes of macaques infected with simian immunodeficiency virus ( SIV) have elevated levels of monocyte chemoattractant protein 2 (MCP-2), demonstrating that chemokine induction also occurs during retroviral infection in vivo. These results show that HIV-1 Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection.[1]

References

  1. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Izmailova, E., Bertley, F.M., Huang, Q., Makori, N., Miller, C.J., Young, R.A., Aldovini, A. Nat. Med. (2003) [Pubmed]
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