Gene Review:
STAT6 - signal transducer and activator of...
Homo sapiens
Synonyms:
D12S1644, IL-4 Stat, IL-4-STAT, STAT6B, STAT6C, ...
Collins,
Weeraratna,
Saloga,
Feltus,
Wijdenes,
Brand,
Tsai,
Van Den Berg,
Aten,
Haqq,
Soucy,
Aldape,
Böttcher,
Dijkink,
Prados,
Chand,
Bellinghausen,
Simard,
Melner,
Hyun,
Taub,
Lakkis,
Key,
Claessen,
Treseler,
Dawson,
Deep-Dixit,
Batchelor,
Shuman,
Okada,
Parikh,
Ginzinger,
Knop,
Rubenstein,
Gingras,
McDermott,
Klostermann,
Fridlyand,
Nadal,
Berger,
Mark H. Kaplan,
Sarita Sehra,
Hua-Chen Chang,
John T. O'Malley,
Anubhav N. Mathur,
Heather A. Bruns,
Weening,
Karch,
Pyle,
Shen,
Ricketts,
- Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Guiter, C., Dusanter-Fourt, I., Copie-Bergman, C., Boulland, M.L., Le Gouvello, S., Gaulard, P., Leroy, K., Castellano, F. Blood (2004)
- STAT-6-mediated control of P-selectin by substance P and interleukin-4 in human dermal endothelial cells. Miyazaki, Y., Satoh, T., Nishioka, K., Yokozeki, H. Am. J. Pathol. (2006)
- Interleukin-4- and -13-induced hypercontractility of human intestinal muscle cells-implication for motility changes in Crohn's disease. Akiho, H., Lovato, P., Deng, Y., Ceponis, P.J., Blennerhassett, P., Collins, S.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Interleukin-13 sensitivity and receptor phenotypes of human glial cell lines: non-neoplastic glia and low-grade astrocytoma differ from malignant glioma. Liu, H., Jacobs, B.S., Liu, J., Prayson, R.A., Estes, M.L., Barnett, G.H., Barna, B.P. Cancer Immunol. Immunother. (2000)
- STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells. Gooch, J.L., Christy, B., Yee, D. Neoplasia (2002)
- Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Cui, X., Zhang, L., Luo, J., Rajasekaran, A., Hazra, S., Cacalano, N., Dubinett, S.M. Oncogene (2007)
- Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. Kaplan, M.H., Sehra, S., Chang, H.C., O'Malley, J.T., Mathur, A.N., Bruns, H.A. Blood (2007)
- Signal transducer and activator of transcription 6 (STAT6) and attention-deficit hyperactivity disorder: A speculative hypothesis. Tsai, S.J. Med. Hypotheses (2006)
- SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Cai, S., Lee, C.C., Kohwi-Shigematsu, T. Nat. Genet. (2006)
- Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, D.A., Huang, X., Koth, L.L., Chang, G.H., Dolganov, G.M., Zhu, Z., Elias, J.A., Sheppard, D., Erle, D.J. Nat. Med. (2002)
- Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Simard, J., Ricketts, M.L., Gingras, S., Soucy, P., Feltus, F.A., Melner, M.H. Endocr. Rev. (2005)
- Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Russell, S.M., Tayebi, N., Nakajima, H., Riedy, M.C., Roberts, J.L., Aman, M.J., Migone, T.S., Noguchi, M., Markert, M.L., Buckley, R.H., O'Shea, J.J., Leonard, W.J. Science (1995)
- An interleukin-4-induced transcription factor: IL-4 Stat. Hou, J., Schindler, U., Henzel, W.J., Ho, T.C., Brasseur, M., McKnight, S.L. Science (1994)
- Gene expression and angiotropism in primary CNS lymphoma. Rubenstein, J.L., Fridlyand, J., Shen, A., Aldape, K., Ginzinger, D., Batchelor, T., Treseler, P., Berger, M., McDermott, M., Prados, M., Karch, J., Okada, C., Hyun, W., Parikh, S., Haqq, C., Shuman, M. Blood (2006)
- Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Dickensheets, H.L., Venkataraman, C., Schindler, U., Donnelly, R.P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway. Kawakami, K., Taguchi, J., Murata, T., Puri, R.K. Blood (2001)
- Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Skinnider, B.F., Elia, A.J., Gascoyne, R.D., Patterson, B., Trumper, L., Kapp, U., Mak, T.W. Blood (2002)
- An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. Litterst, C.M., Pfitzner, E. J. Biol. Chem. (2002)
- IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL. Moreno, J.L., Kaczmarek, M., Keegan, A.D., Tondravi, M. Blood (2003)
- Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. Shankaranarayanan, P., Chaitidis, P., Kühn, H., Nigam, S. J. Biol. Chem. (2001)
- Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Arora, M., Chen, L., Paglia, M., Gallagher, I., Allen, J.E., Vyas, Y.M., Ray, A., Ray, P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6. Bellinghausen, I., Brand, P., Böttcher, I., Klostermann, B., Knop, J., Saloga, J. Immunology (2003)
- Interleukin-13 receptor alpha' but not alpha chain: a functional component of interleukin-4 receptors. Murata, T., Taguchi, J., Puri, R.K. Blood (1998)
- IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. Blanchard, C., Durual, S., Estienne, M., Bouzakri, K., Heim, M.H., Blin, N., Cuber, J.C. J. Immunol. (2004)
- Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. Razeto, A., Ramakrishnan, V., Litterst, C.M., Giller, K., Griesinger, C., Carlomagno, T., Lakomek, N., Heimburg, T., Lodrini, M., Pfitzner, E., Becker, S. J. Mol. Biol. (2004)
- Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits. Moriggl, R., Erhardt, I., Kammer, W., Berchtold, S., Schnarr, B., Lischke, A., Groner, B., Friedrich, K. Eur. J. Biochem. (1998)
- Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency. Taylor, N., Candotti, F., Smith, S., Oakes, S.A., Jahn, T., Isakov, J., Puck, J.M., O'Shea, J.J., Weinberg, K., Johnston, J.A. J. Biol. Chem. (1997)
- Interleukin-12 Drives the Th1 Signaling Pathway in Helicobacter pylori-Infected Human Gastric Mucosa. Pellicanò, A., Sebkova, L., Monteleone, G., Guarnieri, G., Imeneo, M., Pallone, F., Luzza, F. Infect. Immun. (2007)
- Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function. Wang, Y., Malabarba, M.G., Nagy, Z.S., Kirken, R.A. J. Biol. Chem. (2004)
- STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes. Travagli, J., Letourneur, M., Bertoglio, J., Pierre, J. J. Biol. Chem. (2004)
- Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4. Moriggl, R., Kristofic, C., Kinzel, B., Volarevic, S., Groner, B., Brinkmann, V. J. Immunol. (1998)
- Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Matsukura, S., Stellato, C., Georas, S.N., Casolaro, V., Plitt, J.R., Miura, K., Kurosawa, S., Schindler, U., Schleimer, R.P. Am. J. Respir. Cell Mol. Biol. (2001)
- DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. Ehret, G.B., Reichenbach, P., Schindler, U., Horvath, C.M., Fritz, S., Nabholz, M., Bucher, P. J. Biol. Chem. (2001)
- Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells. Van Den Berg, J.G., Aten, J., Chand, M.A., Claessen, N., Dijkink, L., Wijdenes, J., Lakkis, F.G., Weening, J.J. J. Am. Soc. Nephrol. (2000)
- MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. Niu, Y., Murata, T., Watanabe, K., Kawakami, K., Yoshimura, A., Inoue, J., Puri, R.K., Kobayashi, N. FEBS Lett. (2003)
- Regulatory mechanisms of Th2 cytokine-induced eotaxin-3 production in bronchial epithelial cells: possible role of interleukin 4 receptor and nuclear factor-kappaB. Kobayashi, I., Yamamoto, S., Nishi, N., Tsuji, K., Imayoshi, M., Inada, S., Ichiamaru, T., Hamasaki, Y. Ann. Allergy Asthma Immunol. (2004)
- Crystallization and preliminary crystallographic studies of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. Razeto, A., Pfitzner, E., Becker, S. Acta Crystallogr. D Biol. Crystallogr. (2004)
- Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. Dawson, H.D., Collins, G., Pyle, R., Key, M., Weeraratna, A., Deep-Dixit, V., Nadal, C.N., Taub, D.D. BMC Immunol. (2006)