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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic variation at the adipsin locus and response to long-term overfeeding.

OBJECTIVES: The role of adipsin and adipsin Hinc II polymorphisms on the metabolic and body composition changes in response to overfeeding was studied. SUBJECTS: A total of 12 pairs of male monozygotic twins ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. RESULTS: The preoverfeeding plasma adipsin concentration correlated positively with the change in CT-measured abdominal total and subcutaneous (P<0.05) fat. The changes in abdominal total fat and abdominal subcutaneous fat correlated negatively with changes in plasma adipsin concentrations (P<0.005). Overfeeding induced greater increases in body weight, fat mass, abdominal total and subcutaneous fat (P<0.05) in 6.1 kb noncarriers (n=10) than in 6.1 kb carriers (n=14) of the adipsin Hinc II polymorphism. The 6.1 kb noncarriers had a greater increase in plasma leptin levels (P<0.01). Also the total (P<0.01) and very-low-density lipoprotein (VLDL)-triglycerides (P<0.05), apolipoprotein B (P<0.05) and VLDL-cholesterol (P<0.05) levels increased more in the 6.1 kb noncarriers than in the 6.1 kb carriers. CONCLUSIONS: Adipsin plasma level could be a predictor of the changes in abdominal subcutaneous fat during times of increased energy intake. However, a greater increase in the abdominal subcutaneous fat was related to a lower increase in the plasma adipsin level. The adipsin Hinc II 6.1 kb allele noncarriers gained more abdominal subcutaneous fat and had a greater increase in plasma levels of leptin- and triglyceride-rich lipoproteins when exposed to a long-term positive energy balance. These findings provide new information on the role of adipsin on individual differences in response to chronically elevated food intake.[1]


  1. Genetic variation at the adipsin locus and response to long-term overfeeding. Ukkola, O., Chagnon, M., Tremblay, A., Bouchard, C. European journal of clinical nutrition. (2003) [Pubmed]
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