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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development.

Caenorhabditis elegans germ cell proliferation and development were severely damaged in second generation dna-2 homozygotes. Even in the first generation, a much higher incidence of aberrant chromosomes in oocytes and resultantly higher embryonic lethality were found vs. wild type, when DNA breaks were induced by gamma-rays or camptothecin. The deficiency of dna-2 in combination with RNA interference on mre-11 gene expression synergistically aggravated germ-line development, especially oocyte formation. These results suggest that C. elegans Dna-2 is involved in a DNA repair pathway paralleling homologous recombination or non-homologous end joining with mre-11 participation.[1]

References

  1. Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development. Lee, M.H., Han, S.M., Han, J.W., Kim, Y.M., Ahnn, J., Koo, H.S. FEBS Lett. (2003) [Pubmed]
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