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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display.

The differences in gene expression pattern of visceral white adipose tissue between control and high-fat-fed rats were compared using the mRNA differential display methodology. The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7 and four genes downregulated: caveolin-2, lactate dehydrogenase-A, mitochondrial 16S rRNA, and mitochondrial cytochrome oxidase subunit I/serine tRNA. Two of these genes have been already related to obesity (adiponectin and caveolin-2) while the others are known to participate in metabolic, signalling or transcription regulation pathways that can be relevant in energy (lipid and/or carbohydrate) metabolism.[1]

References

  1. Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display. López, I.P., Milagro, F.I., Martí, A., Moreno-Aliaga, M.J., Martínez, J.A., De Miguel, C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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