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Gene Review

Fbn1  -  fibrillin 1

Rattus norvegicus

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Disease relevance of Fbn1


High impact information on Fbn1


Biological context of Fbn1


Anatomical context of Fbn1

  • Type VI collagen and fibrillin were synthesized by cells in the perichondrium-periosteum and by chondrocytes and by stromal osteoblasts and were not modified by higher mechanical forces [5].
  • Types X and VI collagen and fibrillin were localized by in situ hybridization and immunohistochemical methods in the mandibular condyles of rats, and the response of these molecules to post-weaning diets of soft food, ordinary pellets, or hardened pellets was studied [5].

Analytical, diagnostic and therapeutic context of Fbn1


  1. Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis. Porst, M., Daniel, C., Plank, C., Schocklmann, H.O., Reinhardt, D.P., Hartner, A. Nephron Exp. Nephrol. (2006) [Pubmed]
  2. Role of fibrillin-1 in hypertensive and diabetic glomerular disease. Hartner, A., Schaefer, L., Porst, M., Cordasic, N., Gabriel, A., Klanke, B., Reinhardt, D.P., Hilgers, K.F. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  3. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Gong, B., Trent, M.B., Srivastava, D., Boor, P.J. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]
  4. Isolation of rat fibrillin-1 cDNA and its relevance in metanephric development. Kanwar, Y.S., Ota, K., Yang, Q., Kumar, A., Wada, J., Kashihara, N., Peterson, D.R. Am. J. Physiol. (1998) [Pubmed]
  5. The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage. Response to mastication forces. Salo, L.A., Hoyland, J., Ayad, S., Kielty, C.M., Freemont, A., Pirttiniemi, P., Kantomaa, T., Grant, M.E., Thomas, J.T. Acta Odontol. Scand. (1996) [Pubmed]
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