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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Influence of dietary omega-3 polyunsaturated fatty acid (PUFA) supply on brain gene expression.

Background - The functional roles of omega-3 polyunsaturated fatty acids (PUFA) are thought be mediated by the modulation of physico-chemical properties of the cell membrane and eicosanoid metabolism. Recent evidence suggests that omega-3 PUFA might also play a pivotal role in regulation of body functions through the modulation of its genetic apparatus. Objective - To determine the influence of dietary omega-3 PUFA supply on brain gene expression. Design - Female rats were fed with a alpha-linolenic acid (ALA) sufficient (CON) or deficient (DEF) diet throughout gestation and lactation. Three groups of male offspring were studied: (1) pups maintained on CON diet, from mothers on CON diet, CON (n= 4); (2) pups maintained on DEF diet, from mothers on DEF diet, DEF (n=4) (3) pups maintained on CON diet from weaning (3 weeks of age), from mothers on DEF diet, DEF-CON (n=4). Brain gene expression of weanlings and adult offspring were analysed by microarray technique. Confirmation of prominent microarray results was done by RT-PCR. Outcomes - Compared to CON weanlings, a total of 24 known genes and expressed sequence tags (ESTs) were differentially expressed in DEF weanlings. Compared to CON adults, a total of 129 genes and ESTs were differentially expressed in adult DEF offspring; a total of 12 genes and ESTs were differentially expressed in adult DEF-CON animals. Over-expression of the zinc transporter 3 gene was identified as the most prominent change in gene expression due to omega-3 PUFA deficiency. Conclusions - Dietary omega-3 PUFA supply influences the gene expression apparatus of the brain and it may be one of the mechanisms responsible for the physiological actions of the omega-3 PUFA.[1]

References

  1. Influence of dietary omega-3 polyunsaturated fatty acid (PUFA) supply on brain gene expression. Jayasooriya, A.P., Weisinger, R.S., Weisinger, H.S., Mathai, M., Puskas, L., Kitajka, K., Chen, N., Ackland, M.L., Sinclair, A.J. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
 
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