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MeSH Review

Adult Children

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Disease relevance of Adult Children


Psychiatry related information on Adult Children


High impact information on Adult Children


Chemical compound and disease context of Adult Children


Biological context of Adult Children


Anatomical context of Adult Children


Associations of Adult Children with chemical compounds

  • Paternal and maternal death from cancer before age 60 years were associated with higher triglyceride levels in adult sons than in sons whose parents had lived beyond ages 60 and 75 [27].
  • Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion [28].
  • METHOD: Twenty-four-hour urinary cortisol excretion was measured in 35 adult offspring of Holocaust survivors and 15 healthy comparison subjects who were not offspring of Holocaust survivors [6].
  • OBJECTIVE: The authors' goal was to investigate whether maternal smoking during pregnancy is associated with an increased risk of nicotine dependence among adult offspring [29].
  • Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring [30].

Gene context of Adult Children


Analytical, diagnostic and therapeutic context of Adult Children


  1. Remodeling of hippocampal GABAergic system in adult offspring after maternal hypoxia and magnesium sulfate load: immunohistochemical study. Gerstein, M., Huleihel, M., Mane, R., Stilman, M., Kashtuzki, I., Hallak, M., Golan, H. Exp. Neurol. (2005) [Pubmed]
  2. No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone. Dodic, M., Peers, A., Moritz, K., Hantzis, V., Wintour, E.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  3. Glucocorticoids, feto-placental 11 beta-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Seckl, J.R. Steroids (1997) [Pubmed]
  4. Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. Stoker, T.E., Robinette, C.L., Cooper, R.L. Toxicol. Sci. (1999) [Pubmed]
  5. Taurine and taurine-deficiency in the perinatal period. Aerts, L., Van Assche, F.A. Journal of perinatal medicine. (2002) [Pubmed]
  6. Low cortisol and risk for PTSD in adult offspring of holocaust survivors. Yehuda, R., Bierer, L.M., Schmeidler, J., Aferiat, D.H., Breslau, I., Dolan, S. The American journal of psychiatry. (2000) [Pubmed]
  7. Serum prolactin levels in sons of alcoholics and control subjects. Schuckit, M.A., Gold, E., Risch, C. The American journal of psychiatry. (1987) [Pubmed]
  8. Protective effect of the calcium antagonist nimodipine on discrimination learning deficits and impaired retention behavior caused by prenatal nitrite exposure in rats. Nyakas, C., Markel, E., Bohus, B., Schuurman, T., Luiten, P.G. Behav. Brain Res. (1990) [Pubmed]
  9. Altered cocaine-induced behavioral sensitization in adult mice exposed to cocaine in utero. Crozatier, C., Guerriero, R.M., Mathieu, F., Giros, B., Nosten-Bertrand, M., Kosofsky, B.E. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  10. Genetic risk assessment for adult children of people with Alzheimer's disease: the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study. Roberts, J.S., Cupples, L.A., Relkin, N.R., Whitehouse, P.J., Green, R.C. Journal of geriatric psychiatry and neurology. (2005) [Pubmed]
  11. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. Perseghin, G., Price, T.B., Petersen, K.F., Roden, M., Cline, G.W., Gerow, K., Rothman, D.L., Shulman, G.I. N. Engl. J. Med. (1996) [Pubmed]
  12. Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex. Johnston, M.V., Grzanna, R., Coyle, J.T. Science (1979) [Pubmed]
  13. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. Burns, S.P., Desai, M., Cohen, R.D., Hales, C.N., Iles, R.A., Germain, J.P., Going, T.C., Bailey, R.A. J. Clin. Invest. (1997) [Pubmed]
  14. A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Baer, J.S., Sampson, P.D., Barr, H.M., Connor, P.D., Streissguth, A.P. Arch. Gen. Psychiatry (2003) [Pubmed]
  15. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Weaver, I.C., Meaney, M.J., Szyf, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Simple disturbance of the dam in the neonatal period can alter haloperidol-induced catalepsy in the adult offspring. Gallegos, G., Salazar, L., Ortiz, M., Marquez, W., Davis, A., Sanchez, S., Conner, D., Schreiber, H.L. Behavioral and neural biology. (1990) [Pubmed]
  17. Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats. Holemans, K., Aerts, L., Van Assche, F.A. Diabetologia (1991) [Pubmed]
  18. Prenatal ethanol exposure decreases GAP-43 phosphorylation and protein kinase C activity in the hippocampus of adult rat offspring. Perrone-Bizzozero, N.I., Isaacson, T.V., Keidan, G.M., Eriqat, C., Meiri, K.F., Savage, D.D., Allan, A.M. J. Neurochem. (1998) [Pubmed]
  19. Perinatal salt restriction: a new pathway to programming insulin resistance and dyslipidemia in adult wistar rats. Vidonho, A.F., da Silva, A.A., Catanozi, S., Rocha, J.C., Beutel, A., Carillo, B.A., Furukawa, L.N., Campos, R.R., de Toledo Bergamaschi, C.M., Carpinelli, A.R., Quintão, E.C., Dolnikoff, M.S., Heimann, J.C. Pediatr. Res. (2004) [Pubmed]
  20. Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse. Pechnick, R.N., Kariagina, A., Hartvig, E., Bresee, C.J., Poland, R.E., Chesnokova, V.M. Psychopharmacology (Berl.) (2006) [Pubmed]
  21. Tyrosine ingestion during rat pregnancy alters postnatal development of dopaminergic neurons in the offspring. Santana, C., Martin, L., Rodriguez Diaz, M. Brain Res. (1994) [Pubmed]
  22. Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring. Siemelink, M., Verhoef, A., Dormans, J.A., Span, P.N., Piersma, A.H. Diabetologia (2002) [Pubmed]
  23. Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain. Barros, V.G., Berger, M.A., Martijena, I.D., Sarchi, M.I., Pérez, A.A., Molina, V.A., Tarazi, F.I., Antonelli, M.C. J. Neurosci. Res. (2004) [Pubmed]
  24. Prenatal exposure to dexamethasone alters Leydig cell steroidogenic capacity in immature and adult rats. Page, K.C., Sottas, C.M., Hardy, M.P. J. Androl. (2001) [Pubmed]
  25. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation. Ikeda, M., Mitsui, T., Setani, K., Tamura, M., Kakeyama, M., Sone, H., Tohyama, C., Tomita, T. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  26. Reduced serotonin synthesis during early embryogeny changes effect of subsequent prenatal stress on persistent pain in the formalin test in adult male and female rats. Butkevich, I.P., Mikhailenko, V.A., Vershinina, E.A., Khozhai, L.I., Grigorev, I., Otellin, V.A. Brain Res. (2005) [Pubmed]
  27. Progeny's lipid and lipoprotein levels by parental mortality. The Lipid Research Clinics Program Prevalence Study. Glueck, C.J., Laskarzewski, P.M., Suchindran, C.M., Chambless, L.E., Barrett-Connor, E., Stewart, P., Heiss, G., Tyroler, H.A. Circulation (1986) [Pubmed]
  28. Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. Vallée, M., Mayo, W., Dellu, F., Le Moal, M., Simon, H., Maccari, S. J. Neurosci. (1997) [Pubmed]
  29. Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: a 30-year prospective study. Buka, S.L., Shenassa, E.D., Niaura, R. The American journal of psychiatry. (2003) [Pubmed]
  30. Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring. Holemans, K., Gerber, R.T., Meurrens, K., De Clerck, F., Poston, L., Van Assche, F.A. Diabetologia (1999) [Pubmed]
  31. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Brown, A.S., Hooton, J., Schaefer, C.A., Zhang, H., Petkova, E., Babulas, V., Perrin, M., Gorman, J.M., Susser, E.S. The American journal of psychiatry. (2004) [Pubmed]
  32. Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differences. Francis, D.D., Young, L.J., Meaney, M.J., Insel, T.R. J. Neuroendocrinol. (2002) [Pubmed]
  33. Microvascular rarefaction and decreased angiogenesis in rats with fetal programming of hypertension associated with exposure to a low-protein diet in utero. Pladys, P., Sennlaub, F., Brault, S., Checchin, D., Lahaie, I., Lê, N.L., Bibeau, K., Cambonie, G., Abran, D., Brochu, M., Thibault, G., Hardy, P., Chemtob, S., Nuyt, A.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  34. Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring. Galindo, R., Frausto, S., Wolff, C., Caldwell, K.K., Perrone-Bizzozero, N.I., Savage, D.D. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  35. Developmental immunotoxicity of lead in the rat: influence of maternal diet. Chen, S., Golemboski, K., Piepenbrink, M., Dietert, R. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  36. Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. Kinnunen, A.K., Koenig, J.I., Bilbe, G. J. Neurochem. (2003) [Pubmed]
  37. Postnatal development in rat offspring delivered of dams with gestational hyperglycemia. Zhong, S., Dunbar, J.C., Jen, K.L. Am. J. Obstet. Gynecol. (1994) [Pubmed]
  38. Muscle-specific creatine kinase gene polymorphism and VO2max in the HERITAGE Family Study. Rivera, M.A., Dionne, F.T., Simoneau, J.A., Pérusse, L., Chagnon, M., Chagnon, Y., Gagnon, J., Leon, A.S., Rao, D.C., Skinner, J.S., Wilmore, J.H., Bouchard, C. Medicine and science in sports and exercise. (1997) [Pubmed]
  39. Opiate self-administration in adult offspring of methadone-treated female rats. Hovious, J.R., Peters, M.A. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  40. Renin-angiotensin system function and blood pressure in adult rats after perinatal salt overload. da Silva, A.A., de Noronha, I.L., de Oliveira, I.B., Malheiros, D.M., Heimann, J.C. Nutrition, metabolism, and cardiovascular diseases : NMCD. (2003) [Pubmed]
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