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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Substrate-induced production and secretion of cellulases by Clostridium acetobutylicum.

Clostridium acetobutylicum ATCC 824 is a solventogenic bacterium that grows heterotrophically on a variety of carbohydrates, including glucose, cellobiose, xylose, and lichenan, a linear polymer of beta-1,3- and beta-1,4-linked beta-D-glucose units. C. acetobutylicum does not degrade cellulose, although its genome sequence contains several cellulase-encoding genes and a complete cellulosome cluster of cellulosome genes. In the present study, we demonstrate that a low but significant level of induction of cellulase activity occurs during growth on xylose or lichenan. The celF gene, located in the cellulosome-like gene cluster and coding for a unique cellulase that belongs to glycoside hydrolase family 48, was cloned in Escherichia coli, and antibodies were raised against the overproduced CelF protein. A Western blot analysis suggested a possible catabolite repression by glucose or cellobiose and an up-regulation by lichenan or xylose of the extracellular production of CelF by C. acetobutylicum. Possible reasons for the apparent inability of C. acetobutylicum to degrade cellulose are discussed.[1]


  1. Substrate-induced production and secretion of cellulases by Clostridium acetobutylicum. López-Contreras, A.M., Gabor, K., Martens, A.A., Renckens, B.A., Claassen, P.A., Van Der Oost, J., De Vos, W.M. Appl. Environ. Microbiol. (2004) [Pubmed]
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