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Chemical Compound Review

FT-0633529     (2S,3R,4R)-2-(hydroxymethyl)- 3,4-dihydro...

Synonyms: AC1L96YH, C00478
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Disease relevance of C00478


High impact information on C00478


Chemical compound and disease context of C00478


Anatomical context of C00478

  • Lichenan, mannan, and dextran microparticles induced morphological changes in the macrophages when given in nontoxic doses [14].
  • IL-12p40 secretion was significantly upregulated by the beta-glucan lichenan and the heteroglycans Pc-2, Pc-4, thamnolan and Ths-4, while the mature dendritic cells stimulated with the heteroglycan Pc-1 secreted significantly less IL-12p40 than the unstimulated cells [15].
  • This domain bound to pachyman, lichenan, and A. oryzae cell walls [16].

Associations of C00478 with other chemical compounds


Gene context of C00478

  • The celB gene product synthesized in E. coli showed high activity on carboxymethyl cellulose and lichenan while low activity was found on Avicel [19].
  • The microparticles, consisting of crosslinked starch (1,4-alpha-D-glucan with 1,6-alpha-branches), dextran (1,6-alpha-D-glucan with 1,3-alpha-branches), lichenan (1,3-beta-D-glucan), or mannan (1,6-alpha-D-mannan with 1,2-alpha- and 1,3-alpha-branches), were investigated for their macrophage stimulatory properties [14].
  • The technique of sugar analysis is applied to structural studies on natural compounds, e.g. the monosaccharide composition of lichenan and the carbohydrate moiety of the glycoproteins ovomucoid and Collocalia mucoid [20].
  • Four of the polysaccharides upregulated IL-10 secretion by the dendritic cells, as compared with unstimulated cells, the beta-glucans lichenan and Ths-2 and the heteroglycans Pc-4 and thamnolan [15].


  1. Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose. Tsai, L.C., Shyur, L.F., Cheng, Y.S., Lee, S.H. J. Mol. Biol. (2005) [Pubmed]
  2. Synthesis and secretion of a Bacillus circulans WL-12 1,3-1,4-beta-D-glucanase in Escherichia coli. Bueno, A., Vazquez de Aldana, C.R., Correa, J., Villa, T.G., del Rey, F. J. Bacteriol. (1990) [Pubmed]
  3. LicT, a Bacillus subtilis transcriptional antiterminator protein of the BglG family. Schnetz, K., Stülke, J., Gertz, S., Krüger, S., Krieg, M., Hecker, M., Rak, B. J. Bacteriol. (1996) [Pubmed]
  4. Clostridium beijerinckii cells expressing Neocallimastix patriciarum glycoside hydrolases show enhanced lichenan utilization and solvent production. López-Contreras, A.M., Smidt, H., van der Oost, J., Claassen, P.A., Mooibroek, H., de Vos, W.M. Appl. Environ. Microbiol. (2001) [Pubmed]
  5. Cloning and expression of a Bacteroides succinogenes mixed-linkage beta-glucanase (1,3-1,4-beta-D-glucan 4-glucanohydrolase) gene in Escherichia coli. Irvin, J.E., Teather, R.M. Appl. Environ. Microbiol. (1988) [Pubmed]
  6. Substrate-induced production and secretion of cellulases by Clostridium acetobutylicum. López-Contreras, A.M., Gabor, K., Martens, A.A., Renckens, B.A., Claassen, P.A., Van Der Oost, J., De Vos, W.M. Appl. Environ. Microbiol. (2004) [Pubmed]
  7. Characterization of a beta-1,3-glucanase encoded by chlorella virus PBCV-1. Sun, L., Gurnon, J.R., Adams, B.J., Graves, M.V., Van Etten, J.L. Virology (2000) [Pubmed]
  8. Regulation of the lic operon of Bacillus subtilis and characterization of potential phosphorylation sites of the LicR regulator protein by site-directed mutagenesis. Tobisch, S., Stülke, J., Hecker, M. J. Bacteriol. (1999) [Pubmed]
  9. Identification and characterization of a new beta-glucoside utilization system in Bacillus subtilis. Tobisch, S., Glaser, P., Krüger, S., Hecker, M. J. Bacteriol. (1997) [Pubmed]
  10. Characteristics of the endoglucanase encoded by a cel gene from Bacteroides succinogenes expressed in Escherichia coli. Taylor, K.A., Crosby, B., McGavin, M., Forsberg, C.W., Thomas, D.Y. Appl. Environ. Microbiol. (1987) [Pubmed]
  11. Molecular cloning and expression of a Bacillus subtilis beta-glucanase gene in Escherichia coli. Cantwell, B.A., McConnell, D.J. Gene (1983) [Pubmed]
  12. A lichenase-like family 12 endo-(1-->4)-beta-glucanase from Aspergillus japonicus: study of the substrate specificity and mode of action on beta-glucans in comparison with other glycoside hydrolases. Grishutin, S.G., Gusakov, A.V., Dzedzyulya, E.I., Sinitsyn, A.P. Carbohydr. Res. (2006) [Pubmed]
  13. Endoglucanase activity and relative expression of glycoside hydrolase genes of Fibrobacter succinogenes S85 grown on different substrates. Béra-Maillet, C., Gaudet, G., Forano, E. Biochim. Biophys. Acta (2000) [Pubmed]
  14. Biodegradable microspheres. V: Stimulation of macrophages with microparticles made of various polysaccharides. Artursson, P., Arro, E., Edman, P., Ericsson, J.L., Sjöholm, I. Journal of pharmaceutical sciences. (1987) [Pubmed]
  15. Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cells. Omarsdottir, S., Olafsdottir, E.S., Freysdottir, J. Int. Immunopharmacol. (2006) [Pubmed]
  16. Cloning and structural analysis of bglM gene coding for the fungal cell wall-lytic beta-1,3-glucan-hydrolase BglM of Bacillus circulans IAM1165. Asano, T., Taki, J., Yamamoto, M., Aono, R. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  17. Rational approach to fractionation, isolation, and characterization of polysaccharides from the lichen Cetraria islandica. Krämer, P., Wincierz, U., Grübler, G., Tschakert, J., Voelter, W., Mayer, H. Arzneimittel-Forschung. (1995) [Pubmed]
  18. Purification and properties of an acid endo-1,4-beta-glucanase from Bacillus sp. KSM-330. Ozaki, K., Ito, S. J. Gen. Microbiol. (1991) [Pubmed]
  19. Molecular cloning and characterization of a multidomain endoglucanase from Paenibacillus sp BP-23: evaluation of its performance in pulp refining. Pastor, F.I., Pujol, X., Blanco, A., Vidal, T., Torres, A.L., Díaz, P. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  20. Simultaneous assay of neutral sugars and amino sugars by an automatic sugar analyzer: applications to glycoproteins. Kellich, G., Ziegler, D. Hoppe-Seyler's Z. Physiol. Chem. (1975) [Pubmed]
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