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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments--an in vitro study.

OBJECTIVES: The aim of this study was to evaluate the variation of fluid filtration across dentin treated with different formulations of potassium oxalate gels and one gel of acidified sodium fluorophosphate, under five different pre-conditioned dentin surfaces. METHODS: The methodology used for the measurement of hydraulic conductance of dentin in the present study was based on the model suggested by Pashley, Stewart and Galloway [Arch Oral Biol 29 (1984)379]. Two hundred dentin discs 1 mm in thickness, obtained from human extracted third molars, were divided into 20 groups of ten specimens each. The groups corresponded to the following experimental materials: 3% potassium oxalate gel-pH 4; 6% potassium oxalate gel-pH 4; 3% potassium oxalate gel-pH 2.5 and 1.23% fluoride gel (APF gel)-pH 3.6-3.9, applied to dentin under the following surface conditions: air-dried, blot-dried, wet, EDTA air-dried; EDTA blot-dried. General MANOVA and post-hoc Duncan tests were performed on the data. RESULTS: Regardless of surface pre-treatment the 3% potassium oxalate gel-pH 2.5 produced the greatest reduction in dentinal filtration (p<0.05) even after citric acid challenge. In general, air-drying the dentin was the best surface pre-treatment (p<0.05). The interaction between the material and surface pre-treatment showed values of hydraulic conductance similar for most of the combinations, but the 3% potassium oxalate gel-pH 2.5 under wet conditions produced the largest reduction in hydraulic conductance. The APF gel produced the smallest reduction in hydraulic conductance when compared with the other materials, regardless of surface pre-treatment. SIGNIFICANCE: the potassium oxalate gels studied in this investigation have a great potential for tubule occlusion and, consequently, should be effective treatments of dentinal hypersensitivity, regardless of dentin wetness.[1]


  1. Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments--an in vitro study. Pereira, J.C., Segala, A.D., Gillam, D.G. Dental materials : official publication of the Academy of Dental Materials. (2005) [Pubmed]
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