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Gene Review

ZBTB8OS  -  zinc finger and BTB domain containing 8...

Homo sapiens

Synonyms: ARCH, ARCH2, Protein ZBTB8OS, Protein archease, Zinc finger and BTB domain-containing opposite strand protein 8
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Disease relevance of ZBTB8OS

  • We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570] [1].
  • Three monoclonal antibodies [MAb], b-8, b-12, and b-15, have previously been shown to react with mammary carcinomas and with a restricted set of cells in normal human tissues [C. Stähli et al., Experientia (Basel), 41: 1377-1381, 1985; H. R. Zenklusen et al., Virchows Arch. Abt. A Pathol. Anat., 413: 3-10, 1988] [2].
  • Because many patients with adult T-cell leukemia/lymphoma (ATLL) develop hypercalcemia with similar characteristics to those of humoral hypercalcemia of malignancy (HHM) (Arch. Intern. Med., 148: 921-925, 1988), we investigated if ATLL cells produce parathyroid hormone (PTH)-like activity [3].
  • Undifferentiated human melanoma cell lines produce a large chondroitin sulfate proteoglycan, different from the well-known melanoma-specific proteoglycan mel-PG (Heredia and colleagues, Arch Biochem Biophys, 333: 198-206, 1996) [4].
  • Two thioredoxin fractions had previously been reported to occur in Anabaena 7119 by Buchanan and co-workers (Yee, B. C., dela Torre, A., Crawford, N. A., Lara, C., Carlson, D. E., and Buchanan, B. B. (1981) Arch. Microbiol. 130, 14-18) [5].

Psychiatry related information on ZBTB8OS

  • INTERPRETATION: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508-514) according to which midbrain disturbances play an important pathogenic role in TS [6].
  • The present study utilized the National Comorbidity Survey [Arch. Gen. Psychiatry 51 (1994) 8-19] Part II data set to investigate the associations between a chronic pain condition (i.e. arthritis) and common mood and anxiety disorders in a sample representative of the general US civilian population [7].
  • The observation by Strauss (1969. Hallucinations and delusions as points on continua function. Arch. Gen. Psychiatry 21, 581-586) that dichotomously diagnosed psychotic symptoms in clinical samples are, in fact, part of a continuum of experiences, may also apply to the general population [8].
  • A prior study found a selective deficit in verbal working memory in a subgroup of patients with schizophrenia who performed as well as healthy controls on a screening test of attention and auditory perception [Arch. Gen. Psychiatry 55 (1998) 1093] [9].
  • That the systemic effects of propranolol on reconsolidation are achieved via an action in the amygdala is especially important in light of the fact that PTSD involves alterations in the amygdala [Arch Gen Psychiatry 53 (1996) 380] [10].

High impact information on ZBTB8OS

  • The pH titration method of Moisescu and Pusch (Pflügers, Arch., 355, R122, 1975) predicted EGTA purity and Ca(2+) contamination, but K(app) values for EGTA were approximate [11].
  • A beta 1,4-N-acetylgalactosaminyltransferase very similar to that previously described in urine of Sd(a+) individuals (F. Serafini-Cessi, N. Malagolini, and F. Dall'Olio. Arch. Biochem. Biophys., 266: 573-582, 1988) has been identified in cells released from human large intestine [12].
  • The [3H]ADTN binding site with high affinity for neuroleptics demonstrated binding characteristics similar to a site labeled by 3H-Neuroleptics (Sokoloff, P., M. P. Martres, and J. C. Schwartz (1980) Naunyn Schmiedebergs Arch. Pharmacol. 315: 89-102) [13].
  • We showed earlier (H. Z. Hill, et al., Arch Surg., 114: 135-138, 1979) that a single dose of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) administered on Day 0 or on subsequent days was equally effective regardless of the day of administration [14].
  • Mutagenesis studies show that the internal positive charge substitutes for the K(+) requirement (Laughlin, L. T. & Reed, G. H. (1997) Arch. Biochem. Biophys. 348, 262-267) [15].

Chemical compound and disease context of ZBTB8OS

  • As a result, practicing clinicians will find more useful information in existing hypertension and postmyocardial infarction guidelines (Arch Intern Med 1993, 153:154-183 and JAm Coll Cardiol 1996, 28:1328-1428) [16].
  • The hyperfine signals of human, bovine, and chick [2Fe-2S] ferredoxins are described and compared with those of Anabaena 7120 vegetative ferredoxin, a plant-type [2Fe-2S] ferredoxin studied previously [Skjeldal, L., Westler, W. M., & Markley, J. L. (1990) Arch. Biochem. Biophys. 278, 482-485] [17].
  • This report is a sequel to "Why Control Blood Glucose Levels?" (Arch Surg 111:229, 1976), which linked complications of diabetes mellitus to poor control [18].
  • These changes resemble those found in patients with liver insufficiency (J.P. Buchet, A. Geubel, S. Pauwels, P. Mahieu, and R. Lauwerys (1984). The influence of liver disease on the methylation of arsenite in humans. Arch. Toxicol. 55, 151-154) [19].
  • Legionella micdadei cells contain an acid phosphatase (ACP2) which blocks superoxide anion production by human neutrophils stimulated with formyl-Met-Leu-Phe (fMLP) [A. K. Saha, et al. (1985) Arch. Biochem. Biophys. 243, 150-160] [20].

Biological context of ZBTB8OS

  • Trans-Caffeoyl-CoA 3-O-methyltransferase is involved in the reinforcement of the plant cell wall under conditions that trigger the disease resistance response (Pakusch, A.-E., Kneusel, R.E., and Matern, U. (1989) Arch. Biochem. Biophys. 271, 488-494) [21].
  • Notice of Retraction: "The relation between pulse pressure and cardiovascular mortality in 12,763 middle-aged men from various parts of the world: A 25-year follow-up of the seven countries study" (Arch Intern Med. 2005;165:2142-2147) [22].
  • The 79-amino-acid (79-aa) open reading frame (UL111a) gene within morphological transforming region II (mtrII) of human cytomegalovirus strain Towne has been shown to transform rodent cells in vitro (J. Thompson, J. Doniger, and L. J. Rosenthal, Arch. Virol. 136:161-172, 1994) [23].
  • (Neurology 42 (1992) 1743-1750; Arch Neurology 54 (1997) 1521-1531) against those measured to include the posterior tail section [24].
  • The number of methylation sites in alpha Bgt has been shown to decrease significantly upon binding of the toxin to the AcChR [Soler, G., Farach, M. C., Farach, H. A., Mattingly, J. R., & Martinez-Carrion, M. (1983) Arch. Biochem. Biophys. 225, 872-878] [25].

Anatomical context of ZBTB8OS

  • In addition to two major alpha- and beta-subunits, the soluble oligomycin-insensitive F1ATPase purified from sweet potato root mitochondria contains four different minor subunits of gamma (Mr = 35,500), delta (Mr = 27,000), delta' (Mr = 23,000), and epsilon (Mr = 12,000) (Iwasaki, Y., and Asashi, T. (1983) Arch. Biochem. Biophys. 227, 164-173) [26].
  • Pettegrew et al (Arch Gen Psychiatry 48:563-568, 1991) were the first to determine abnormalities concerning phospholipids and high energy metabolites in the dorsolateral prefrontal cortex of drug-naive schizophrenics with 31P magnetic resonance spectroscopy (MRS) [27].
  • Partially and completely empty cytoplasmic granules, characteristic for piecemeal degranulation (Dvorak et al., Int Arch Allergy Immunol 1992;99:74-83) had diminished and absent histamine stores, whereas electron-dense granules in the same cells retained their histamine [28].
  • This EEG pattern has been extensively studied since 1938, when Jung and Kornmuller (28) (Eine methodik der ableitung lokalisierter potential schwankingen aus subcorticalen hirnyebieten, Arch. Psychiat. Neruenkr. 109 (1938) 1-30) demonstrated the first theta recordings in the hippocampal formation of rabbits [29].
  • 72% of cytosolic proteins in fibroblasts (Prows et al. 1997. Arch. Biochem. Biophys. 340: 135) [30].

Associations of ZBTB8OS with chemical compounds

  • Azari and Phillips (Azari, P., and Phillips, J. L. 1970 Arch. Biochem. Biophys. 138, 32-38) reported that periodate treatment of iron-free ovotransferrin causes a rapid loss of iron-binding activity and an oxidation of 3 to 5 tyrosines and 1 tryptophan [31].
  • Since binding of ligands does not influence quaternary structure (Seery, V.L., and Farrell, H. M., Jr. (1989) Arch. Biochem. Biophys. 274, 453-462), activation of isocitrate dehydrogenase may be related to a substrate-induced conformational transition [32].
  • With human hemoglobin A, methyl acetyl phosphate competes with 2,3-diphosphoglycerate and acetylates only Val-1(beta), Lys-82(beta), and Lys-144(beta) within or near the cleft that binds this organic phosphate (Ueno, H., Pospischil, M. A., Manning, J. M., and Kluger, R. (1986) Arch Biochem. Biophys. 244, 795) [33].
  • Our previous studies identified two noncovalent flavin-binding regions in MAO B (residues 6-34 and 39-46) (Kwan, S.-W., Lewis, D. A., Zhou, B. P., and Abell, C. W. (1995) Arch. Biochem. Biophys. 316, 385-391; Zhou, B. P., Lewis, D. A., Kwan, S.-W., Kirksey, T. J., and Abell, C. W. (1995) Biochemistry 34, 9526-9531) [34].
  • The kinetic mechanism developed from these results is capable of explaining the formation of fatty acids from malonyl-CoA and NADPH alone (Katiyar, S. S., Briedis, A. V., and Porter, J. W. (1974) Arch. Biochem. Biophys. 162, 412-420) and also the formation of triacetic acid lactone from either malonyl-CoA alone or acetyl-CoA plus malonyl-CoA [35].

Analytical, diagnostic and therapeutic context of ZBTB8OS

  • Partially purified human renin (Haas et al., Arch. Biochem. Biophys., 110, 534-543, 1965) was purified further by affinity chromatography on the pepstatin-aminohexyl-agarose gel, gel filtration on a Sephadex G-75 column, and ion exchange chromatography on a DEAE-cellulose column [36].
  • In a recent publication (Michel et al. Arch. Biochem. Biophys. 439:234-240; 2005) the authors argued that the catalytic rate constant, k(cat), for wild-type Cu,Zn-superoxide dismutase (Cu,Zn-SOD), determined previously by pulse radiolysis, was overestimated due to contamination with excess copper [37].
  • Re-analysis of the original data validating ultrafiltration in free-ligand determinations (Sophianopoulos et al., Arch Biochem Biophys 1978;187:132-7) confirms this prediction [38].
  • [(1967) Arch. Biochem. Biophys. 121, 29], which were obtained by countercurrent distribution of tritium-labeled products and their identification by scintillation counting [39].
  • PEC strain Cowden grows to low to moderate titers in cell culture but only with the addition of intestinal contents from uninfected gnotobiotic pigs (W. T. Flynn and L. J. Saif, J. Clin. Microbiol. 26:206--212, 1988; A. V. Parwani, W. T. Flynn, K. L. Gadfield, and L. J. Saif, Arch. Virol. 120:115--122, 1991) [40].


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  2. Mucin-like carcinoma-associated antigen defined by three monoclonal antibodies against different epitopes. Stähli, C., Caravatti, M., Aeschbacher, M., Kocyba, C., Takacs, B., Carmann, H. Cancer Res. (1988) [Pubmed]
  3. Secretion of parathyroid hormone-like activity from human T-cell lymphotropic virus type I-infected lymphocytes. Fukumoto, S., Matsumoto, T., Watanabe, T., Takahashi, H., Miyoshi, I., Ogata, E. Cancer Res. (1989) [Pubmed]
  4. Versican is differentially expressed in human melanoma and may play a role in tumor development. Touab, M., Villena, J., Barranco, C., Arumí-Uría, M., Bassols, A. Am. J. Pathol. (2002) [Pubmed]
  5. Isolation and characterization of thioredoxin f from the filamentous cyanobacterium, Anabaena sp. 7119. Whittaker, M.M., Gleason, F.K. J. Biol. Chem. (1984) [Pubmed]
  6. Increased midbrain gray matter in Tourette's syndrome. Garraux, G., Goldfine, A., Bohlhalter, S., Lerner, A., Hanakawa, T., Hallett, M. Ann. Neurol. (2006) [Pubmed]
  7. Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample. McWilliams, L.A., Cox, B.J., Enns, M.W. Pain (2003) [Pubmed]
  8. Strauss (1969) revisited: a psychosis continuum in the general population? van Os, J., Hanssen, M., Bijl, R.V., Ravelli, A. Schizophr. Res. (2000) [Pubmed]
  9. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Bruder, G.E., Wexler, B.E., Sage, M.M., Gil, R.B., Gorman, J.M. Schizophr. Res. (2004) [Pubmed]
  10. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Debiec, J., Ledoux, J.E. Neuroscience (2004) [Pubmed]
  11. Critical review of the methods used to measure the apparent dissociation constant and ligand purity in Ca(2+) and Mg(2+) buffer solutions. McGuigan, J.A., Kay, J.W., Elder, H.Y. Prog. Biophys. Mol. Biol. (2006) [Pubmed]
  12. Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas. Malagolini, N., Dall'Olio, F., Di Stefano, G., Minni, F., Marrano, D., Serafini-Cessi, F. Cancer Res. (1989) [Pubmed]
  13. Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics. List, S.J., Wreggett, K.A., Seeman, P. J. Neurosci. (1982) [Pubmed]
  14. Effect of scheduling of combinations of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea on the Harding-Passey and Cloudman S91 mouse melanomas. Hill, H.Z., Hill, G.J. Cancer Res. (1982) [Pubmed]
  15. Dichotomic Phylogenetic Tree of the Pyruvate Kinase Family: K+-DEPENDENT AND -INDEPENDENT ENZYMES. Oria-Hern??ndez, J., Riveros-Rosas, H., Ram??rez-S??lva, L. J. Biol. Chem. (2006) [Pubmed]
  16. Clinical implications of the World Health Organization-International Society of Hypertension statement on calcium antagonists. Psaty, B.M., Furberg, C.D. J. Hypertens. (1997) [Pubmed]
  17. 1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins. Skjeldal, L., Markley, J.L., Coghlan, V.M., Vickery, L.E. Biochemistry (1991) [Pubmed]
  18. How to control the blood glucose level in the surgical diabetic patient. Rossini, A.A., Hare, J.W. Archives of surgery (Chicago, Ill. : 1960) (1976) [Pubmed]
  19. Study of factors influencing the in vivo methylation of inorganic arsenic in rats. Buchet, J.P., Lauwerys, R. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  20. Legionella micdadei phosphatase catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate in human neutrophils. Saha, A.K., Dowling, J.N., Pasculle, A.W., Glew, R.H. Arch. Biochem. Biophys. (1988) [Pubmed]
  21. Molecular cloning, induction and taxonomic distribution of caffeoyl-CoA 3-O-methyltransferase, an enzyme involved in disease resistance. Schmitt, D., Pakusch, A.E., Matern, U. J. Biol. Chem. (1991) [Pubmed]
  22. Notice of Retraction: "The relation between pulse pressure and cardiovascular mortality in 12,763 middle-aged men from various parts of the world: A 25-year follow-up of the seven countries study" (Arch Intern Med. 2005;165:2142-2147). Greenland, P. Arch. Intern. Med. (2006) [Pubmed]
  23. Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription. Muralidhar, S., Doniger, J., Mendelson, E., Araujo, J.C., Kashanchi, F., Azumi, N., Brady, J.N., Rosenthal, L.J. J. Virol. (1996) [Pubmed]
  24. Sex and symmetry differences in hippocampal volumetrics: before and beyond the opening of the crus of the fornix. Maller, J.J., Réglade-Meslin, C., Anstey, K.J., Sachdev, P. Hippocampus. (2006) [Pubmed]
  25. Reductive methylation as a tool for the identification of the amino groups in alpha-bungarotoxin interacting with nicotinic acetylcholine receptor. Garcia-Borron, J.C., Bieber, A.L., Martinez-Carrion, M. Biochemistry (1987) [Pubmed]
  26. Correspondence of minor subunits of plant mitochondrial F1ATPase to F1F0ATPase subunits of other organisms. Kimura, T., Nakamura, K., Kajiura, H., Hattori, H., Nelson, N., Asahi, T. J. Biol. Chem. (1989) [Pubmed]
  27. 31P magnetic resonance spectroscopy in the dorsolateral prefrontal cortex of schizophrenics with a volume selective technique--preliminary findings. Volz, H.P., Rzanny, R., May, S., Hegewald, H., Preussler, B., Hajek, M., Kaiser, W.A., Sauer, H. Biol. Psychiatry (1997) [Pubmed]
  28. Diamine oxidase-gold enzyme-affinity ultrastructural demonstration that human gut mucosal mast cells secrete histamine by piecemeal degranulation in vivo. Dvorak, A.M., Morgan, E.S. J. Allergy Clin. Immunol. (1997) [Pubmed]
  29. Theta-like activity in the limbic cortex in vitro. Konopacki, J. Neuroscience and biobehavioral reviews. (1998) [Pubmed]
  30. Effects of intestinal fatty acid-binding protein overexpression on fatty acid metabolism in Caco-2 cells. Darimont, C., Gradoux, N., Persohn, E., Cumin, F., De Pover, A. J. Lipid Res. (2000) [Pubmed]
  31. Periodate inactivation of ovotransferrin and human serum transferrin. Geoghegan, K.F., Dallas, J.L., Feeney, R.E. J. Biol. Chem. (1980) [Pubmed]
  32. Spectroscopic evidence for ligand-induced conformational change in NADP+:isocitrate dehydrogenase. Seery, V.L., Farrell, H.M. J. Biol. Chem. (1990) [Pubmed]
  33. Methyl acetyl phosphate as a covalent probe for anion-binding sites in human and bovine hemoglobins. Ueno, H., Pospischil, M.A., Manning, J.M. J. Biol. Chem. (1989) [Pubmed]
  34. Characterization of a highly conserved FAD-binding site in human monoamine oxidase B. Zhou, B.P., Wu, B., Kwan, S.W., Abell, C.W. J. Biol. Chem. (1998) [Pubmed]
  35. Fatty acid synthetase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from pigeon liver. Katiyar, S.S., Cleland, W.W., Porter, J.W. J. Biol. Chem. (1975) [Pubmed]
  36. Partial purification of human renin. Murakami, K., Inagami, T., Haas, E. Circ. Res. (1977) [Pubmed]
  37. Kinetic properties of Cu,Zn-superoxide dismutase as a function of metal content-Order restored. Goldstein, S., Fridovich, I., Czapski, G. Free Radic. Biol. Med. (2006) [Pubmed]
  38. Protocols for use of ultrafiltration in determination of free ligand concentration and of complexity of ligand/protein interactions. Wolfer, G.K., Rippon, W.B. Clin. Chem. (1987) [Pubmed]
  39. Small molecular products of dealkylation in soman-inhibited electric eel acetylcholinesterase. Viragh, C., Kovach, I.M., Pannell, L. Biochemistry (1999) [Pubmed]
  40. Expression and self-assembly in baculovirus of porcine enteric calicivirus capsids into virus-like particles and their use in an enzyme-linked immunosorbent assay for antibody detection in swine. Guo, M., Qian, Y., Chang, K.O., Saif, L.J. J. Clin. Microbiol. (2001) [Pubmed]
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