Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ishimitsu, T. et al.

Ishimitsu, Ohta, Saito, Teranishi, Inada, Yoshii, Minami, Ono, Hikawa, Shibata, Sugaya, Kamijo, Kimura, Ohrui, Matsuoka,

Urinary excretion of liver fatty acid-binding protein in health-check participants.

BACKGROUND: Messenger RNA of liver fatty acid-binding protein (L-FABP) is expressed in proximal tubules of the kidney, and a certain amount is excreted into urine. We analyzed factors relating to the urinary L-FABP excretion in health-check participants. METHODS: We measured L-FABP in the first morning urine by ELISA in 715 men and 193 women 30-79 years of age who entered a 2-day hospitalized health checkup program. In addition to the routine physical examination and laboratory tests, plasma high-sensitivity C-reactive protein ( HSCRP) was assayed. RESULTS: In 150 healthy subjects, urinary L-FABP averaged 3.6 +/- 0.2 microg/g creatinine, whereas the values were significantly increased in patients with hypertension (5.2 +/- 0.4, P = 0.010), diabetes mellitus (5.5 +/- 0.5, P < 0.001), and chronic hepatitis (5.8 +/- 1.0, P = 0.022). Urinary L-FABP excretion was significantly greater in women than in men when the value was related to creatinine. In regression analysis in men, urinary L-FABP was positively correlated with fasting plasma glucose (r = 0.103, P = 0.033) and plasma HSCRP (r = 0.135, P = 0.006). CONCLUSIONS: It is suggested that renal production and urinary excretion of L-FABP are increased in situations in which arteriosclerosis is promoted, such as hypertension, diabetes mellitus, and cardiovascular inflammation.[1]

References

Urinary excretion of liver fatty acid-binding protein in health-check participants. Ishimitsu, T., Ohta, S., Saito, M., Teranishi, M., Inada, H., Yoshii, M., Minami, J., Ono, H., Hikawa, A., Shibata, N., Sugaya, T., Kamijo, A., Kimura, K., Ohrui, M., Matsuoka, H. Clin. Exp. Nephrol. (2005) [Pubmed]

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