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Gene Review

FABP1  -  fatty acid binding protein 1, liver

Homo sapiens

Synonyms: FABPL, Fatty acid-binding protein 1, Fatty acid-binding protein, liver, L-FABP, Liver-type fatty acid-binding protein
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Disease relevance of FABP1

  • How these signaling molecules reach the nuclear receptor is not known; however, similarities in ligand specificity suggest the liver fatty acid binding protein (L-FABP) as a possible candidate [1].
  • Furthermore, cobalt, a chemical agent known to mimic hypoxia, inhibits trophoblast cells differentiation and diminishes H-, L-FABP and PPARs expression [2].
  • OBJECTIVE: Liver-type fatty acid-binding protein (l-FABP) is expressed in renal proximal tubules and is reported to be a useful marker for progression of chronic glomerulonephritis [3].
  • Elevated plasma levels of both I-FABP and L-FABP were found in patients suffering from intestinal diseases, while only L-FABP was increased in cases of purely hepatocellular injury [4].
  • Even though linoleate and CLA were incorporated into lipids of hepatoma cells to the same extent, linoleate had little or no effect on ACO, CYP4A1, or L-FABP mRNA [5].

High impact information on FABP1

  • The intestine is lined by a continuously regenerating epithelium that maintains gradients in 'liver' fatty acid binding protein (L-FABP) gene expression along its horizontal and vertical axes, i.e., from duodenum to colon and from crypt to villus tip [6].
  • Nucleotides -596 to +21 of the rat L-FABP gene correctly directed hGH expression to enterocytes and hepatocytes [6].
  • To identify cis-acting DNA sequences responsible for these regional differences, we linked portions of the L-FABP gene's 5' nontranscribed region to the human growth hormone (hGH) gene and examined hGH expression in transgenic mice [6].
  • The "liver" fatty acid binding protein (L-FABP) gene represents a useful model for analyzing the molecular basis for intestinal epithelial differentiation since it exhibits cell-specific, region-specific, as well as developmental stage specific expression [7].
  • In addition, L-FABP/hGH fusion genes were used to identify subsets of enteroendocrine cells based on their ability to support hGH synthesis in several different pedigrees of transgenic mice [7].

Chemical compound and disease context of FABP1


Biological context of FABP1


Anatomical context of FABP1


Associations of FABP1 with chemical compounds

  • In vitro binding studies revealed that the bacterially expressed recombinant I-15P showed much lower affinities for palmitate and oleate than L-FABP [18].
  • In conclusion, this study showed that there is no correlation between the expression of H- and L-FABP and LA uptake by trophoblast cells and that bezafibrate and LA greatly impaired trophoblast cells differentiation [2].
  • Urinary l-FABP levels in groups B-D were significantly higher than those in healthy subjects (group E, 5.8 +/- 4.0 microg/g creatinine) (group B, P < 0.05; group C, P < 0.01; group D, P < 0.01) [3].
  • Moreover, treatment of hepatocytes with antisense mRNA directed against ES10 or L-FABP abolished both tamoxifen and MBoPE binding [19].
  • Inhibition of P-450 4A1 markedly diminished, via a pre-translational mechanism, the CF induction of L-FABP and peroxisomal beta-oxidation [20].

Physical interactions of FABP1


Regulatory relationships of FABP1

  • Similarly, hydrocortisone and insulin enhanced the cellular content of I- and L-FABP whereas leptin triggered I-FABP expression only after an 8-hour incubation [25].
  • Female rats differ from males, however, in showing a greater hepatic abundance of L-FABP which is expressed almost equally throughout the acinus [26].

Other interactions of FABP1


Analytical, diagnostic and therapeutic context of FABP1


  1. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Wolfrum, C., Borrmann, C.M., Borchers, T., Spener, F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. Daoud, G., Simoneau, L., Masse, A., Rassart, E., Lafond, J. Biochim. Biophys. Acta (2005) [Pubmed]
  3. Effect of pitavastatin on urinary liver-type fatty acid-binding protein levels in patients with early diabetic nephropathy. Nakamura, T., Sugaya, T., Kawagoe, Y., Ueda, Y., Osada, S., Koide, H. Diabetes Care (2005) [Pubmed]
  4. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. Pelsers, M.M., Namiot, Z., Kisielewski, W., Namiot, A., Januszkiewicz, M., Hermens, W.T., Glatz, J.F. Clin. Biochem. (2003) [Pubmed]
  5. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. Moya-Camarena, S.Y., Vanden Heuvel, J.P., Blanchard, S.G., Leesnitzer, L.A., Belury, M.A. J. Lipid Res. (1999) [Pubmed]
  6. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Sweetser, D.A., Birkenmeier, E.H., Hoppe, P.C., McKeel, D.W., Gordon, J.I. Genes Dev. (1988) [Pubmed]
  7. Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract. Roth, K.A., Hertz, J.M., Gordon, J.I. J. Cell Biol. (1990) [Pubmed]
  8. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. Brouillette, C., Bossé, Y., Pérusse, L., Gaudet, D., Vohl, M.C. J. Hum. Genet. (2004) [Pubmed]
  9. Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment. Rajaraman, G., Wang, G.Q., Yan, J., Jiang, P., Gong, Y., Burczynski, F.J. Mol. Cell. Biochem. (2007) [Pubmed]
  10. Urinary excretion of liver fatty acid-binding protein in health-check participants. Ishimitsu, T., Ohta, S., Saito, M., Teranishi, M., Inada, H., Yoshii, M., Minami, J., Ono, H., Hikawa, A., Shibata, N., Sugaya, T., Kamijo, A., Kimura, K., Ohrui, M., Matsuoka, H. Clin. Exp. Nephrol. (2005) [Pubmed]
  11. Down-regulation of liver and heart specific fatty acid binding proteins by endotoxin and cytokines in vivo. Memon, R.A., Bass, N.M., Moser, A.H., Fuller, J., Appel, R., Grunfeld, C., Feingold, K.R. Biochim. Biophys. Acta (1999) [Pubmed]
  12. Changes in mRNA levels of intracellular fatty acid metabolism regulators in human hepatoma HepG2 cells following their treatment with non-esterified fatty acids and dehydroepiandrosterone. Rypka, M., Cervenková, K., Uherková, L., Poczatková, H., Bogdanová, K., Veselý, J. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia. (2005) [Pubmed]
  13. Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6. Fowler, K.J., Mann, G.B., Dunn, A.R. Genomics (1993) [Pubmed]
  14. Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications. Chan, L., Wei, C.F., Li, W.H., Yang, C.Y., Ratner, P., Pownall, H., Gotto, A.M., Smith, L.C. J. Biol. Chem. (1985) [Pubmed]
  15. Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells. Wang, G., Gong, Y., Anderson, J., Sun, D., Minuk, G., Roberts, M.S., Burczynski, F.J. Hepatology (2005) [Pubmed]
  16. Ligand specificity and conformational stability of human fatty acid-binding proteins. Zimmerman, A.W., van Moerkerk, H.T., Veerkamp, J.H. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  17. Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver. Wolfrum, C., Börchers, T., Sacchettini, J.C., Spener, F. Biochemistry (2000) [Pubmed]
  18. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Fujita, M., Fujii, H., Kanda, T., Sato, E., Hatakeyama, K., Ono, T. Eur. J. Biochem. (1995) [Pubmed]
  19. Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone. Mésange, F., Sebbar, M., Capdevielle, J., Guillemot, J.C., Ferrara, P., Bayard, F., Poirot, M., Faye, J.C. Bioconjug. Chem. (2002) [Pubmed]
  20. Mechanisms of regulation of liver fatty acid-binding protein. Kaikaus, R.M., Chan, W.K., Ortiz de Montellano, P.R., Bass, N.M. Mol. Cell. Biochem. (1993) [Pubmed]
  21. Insights into binding of fatty acids by fatty acid binding proteins. Hanhoff, T., Lücke, C., Spener, F. Mol. Cell. Biochem. (2002) [Pubmed]
  22. Time-resolved fluorescence of intestinal and liver fatty acid binding proteins: role of fatty acyl CoA and fatty acid. Frolov, A., Schroeder, F. Biochemistry (1997) [Pubmed]
  23. Diagnostic value of heart fatty acid binding protein and myoglobin in patients admitted with chest pain. Alansari, S.E., Croal, B.L. Ann. Clin. Biochem. (2004) [Pubmed]
  24. Effect of pitavastatin on urinary liver-type fatty-acid-binding protein in patients with nondiabetic mild chronic kidney disease. Nakamura, T., Sugaya, T., Kawagoe, Y., Suzuki, T., Inoue, T., Node, K. American journal of nephrology. (2006) [Pubmed]
  25. Modulation of intestinal and liver fatty acid-binding proteins in Caco-2 cells by lipids, hormones and cytokines. Dubé, N., Delvin, E., Yotov, W., Garofalo, C., Bendayan, M., Veerkamp, J.H., Levy, E. J. Cell. Biochem. (2001) [Pubmed]
  26. Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism. Bass, N.M. Mol. Cell. Biochem. (1990) [Pubmed]
  27. Fatty acid-binding proteins as plasma markers of tissue injury. Pelsers, M.M., Hermens, W.T., Glatz, J.F. Clin. Chim. Acta (2005) [Pubmed]
  28. HNF-1alpha and endodermal transcription factors cooperatively activate Fabpl: MODY3 mutations abrogate cooperativity. Divine, J.K., McCaul, S.P., Simon, T.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
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