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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Apoptosis, proliferation and gene expression patterns in mouse developing tongue.

The Fgf/Fgfr (Fgf receptor) and Bmp signal pathways are critical for embryonic development and postnatal growth. In order to address their roles in tongue development, preliminary study of expression patterns of some important members in the two families, as well as of apoptosis and proliferation, were carried out in mouse developing tongue. Apoptosis in tongue is a very late event in embryogenesis, restricted to the upper layer of the epithelium whereas proliferation is very vigorous at the early stage of tongue development and remains active throughout embryogenesis. Bmp2, -4 and -5 were localized within the mesenchyme at the early embryonic stage of tongue development ( E12 to E13), whereas Bmp3 and Bmp7 were mainly expressed in the epithelium. Most of these molecules were also seen in the tongue muscles at postnatal stages. Among Fgfr isoforms, Fgfr1c, -2b, and -2c were detected in embryogenesis with peak expression at E11 to E13. Fgfr1c and Fgfr2c were localized within the mesenchyme, while Fgfr2b was mainly expressed in the epithelium. High expression of Fgf7 and Fgf10 was also detected in the mesenchyme at the early embryonic stage of tongue development, corresponding to the Fgfr expression, suggesting that they are among the principal ligands functioning at the early embryonic expanding stage. Fgf2 was seen in the tongue muscles at the late embryonic and postnatal stages. These results suggest that Bmp and Fgf signalling regulates tongue development at multiple stages, possibly related to proliferation and differentiation.[1]


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