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Gene Review

Bmp3  -  bone morphogenetic protein 3

Mus musculus

Synonyms: 9130206H07, 9530029I04Rik, BMP-3, Bone morphogenetic protein 3
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High impact information on Bmp3

  • Finally, Bmp3(-/-) mice have twice as much trabecular bone as wild-type littermates, indicating that BMP3, the most abundant BMP in adult bone, is a negative determinant of bone density [1].
  • In contrast, BMP-3, BMP-4, BMP-7, and BMP-8 showed a restricted period of expression from day 14 through day 21, when the resorption of calcified cartilage and osteoblastic recruitment were most active [2].
  • Growth/differentiation factor-10 (GDF-10) is a TGF-beta family member highly related to bone morphogenetic protein-3 [3].
  • Msx2 expression continued in the epithelial cell rests of Malassez, and the nearby cementoblasts intensely expressed Bmp3, which may regulate some functions of the fragmented epithelium [4].
  • They as well as Bmp-5 may be involved in the induction and formation of dentine and enamel, and Bmp-3 in the development of cementum [5].

Biological context of Bmp3

  • On an outbred genetic background, Bmp3-/- mice are viable and show no obvious skeletal phenotype as embryos or neonates [6].
  • This observation is consistent with our in vitro observations suggesting that BMP3 is an inhibitor of osteogenesis in vitro and of bone formation in vivo [6].
  • By applying this technique, early phase bone morphogenetic protein-3 mRNA in the nuclei and cytoplasm was successfully demonstrated in a differentiating chondrocytic cell lineage [7].
  • In particular, elevated expression of SFRP5, an inhibitor of Wnt signaling, the imprinted gene MEST and BMP3 may be causally linked to fat mass expansion, since differences in gene expression observed in biopsies of epididymal fat at 7 wk of age (before the high-fat diet) correlated with adiposity after 8 wk on a high-fat diet [8].

Anatomical context of Bmp3


Associations of Bmp3 with chemical compounds

  • MBA-15.33, MBA-15.4, and MBA-15.6 cells were exposed to dexamethasone or to various growth factors (bone morphogenic protein (BMP-2 and BMP-3), TGF beta, and IGF-1) [12].
  • BMP-3 mRNA expression were almost negative in either control or retinoic acid-treated groups during all stages [13].


  1. Bone morphogenetic protein-3 is a negative regulator of bone density. Daluiski, A., Engstrand, T., Bahamonde, M.E., Gamer, L.W., Agius, E., Stevenson, S.L., Cox, K., Rosen, V., Lyons, K.M. Nat. Genet. (2001) [Pubmed]
  2. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. Cho, T.J., Gerstenfeld, L.C., Einhorn, T.A. J. Bone Miner. Res. (2002) [Pubmed]
  3. Characterization of GDF-10 expression patterns and null mice. Zhao, R., Lawler, A.M., Lee, S.J. Dev. Biol. (1999) [Pubmed]
  4. Expression of bone morphogenetic proteins and Msx genes during root formation. Yamashiro, T., Tummers, M., Thesleff, I. J. Dent. Res. (2003) [Pubmed]
  5. Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Aberg, T., Wozney, J., Thesleff, I. Dev. Dyn. (1997) [Pubmed]
  6. BMP3: to be or not to be a BMP. Bahamonde, M.E., Lyons, K.M. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  7. Application trials of in situ hybridization at the electron microscopic level. Kitazawa, S., Kondo, T., Kitazawa, R. Neuropathology : official journal of the Japanese Society of Neuropathology. (2005) [Pubmed]
  8. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. Koza, R.A., Nikonova, L., Hogan, J., Rim, J.S., Mendoza, T., Faulk, C., Skaf, J., Kozak, L.P. PLoS Genet. (2006) [Pubmed]
  9. Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures. Thomadakis, G., Ramoshebi, L.N., Crooks, J., Rueger, D.C., Ripamonti, U. Eur. J. Oral Sci. (1999) [Pubmed]
  10. Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mousecranial base. Kettunen, P., Nie, X., Kvinnsland, I.H., Luukko, K. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology (2006) [Pubmed]
  11. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Chen, D., Harris, M.A., Rossini, G., Dunstan, C.R., Dallas, S.L., Feng, J.Q., Mundy, G.R., Harris, S.E. Calcif. Tissue Int. (1997) [Pubmed]
  12. Dexamethasone regulation of marrow stromal-derived osteoblastic cells. Fried, A., Benayahu, D. J. Cell. Biochem. (1996) [Pubmed]
  13. Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice. Lu, H., Jin, Y., Tipoe, G.L. Arch. Oral Biol. (2000) [Pubmed]
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