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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells.

Bone morphogenetic proteins (BMPs) initiate, promote, and maintain chondrogenesis and osteogenesis. We hypothesize that BMP-2 induces an osteogenic, and BMP-7 a chondrogenic phenotype in adipose tissue-derived mesenchymal stem cells (AT-MSCs). We compared the effects of a short 15min BMP-2 or BMP-7 (10ng/ml) treatment on osteogenic and chondrogenic differentiation of AT-MSCs. Gene expression was studied 4 and 14 days after BMP-treatment. At day 4 BMP-2, but not BMP-7, stimulated runx-2 and osteopontin gene expression, and at day 14 BMP-7 down-regulated expression of these genes. At day 4 BMP-2 and BMP-7 stimulated biglycan gene expression, which was down-regulated by BMP-7 at day 14. BMP-7 stimulated aggrecan gene expression at day 14. Our data indicate that BMP-2 treatment for 15min induces osteogenic differentiation, whereas BMP-7 stimulates a chondrogenic phenotype of AT-MSCs. Therefore, AT-MSCs triggered for only 15min with BMP-2 or BMP-7 provide a feasible tool for bone and cartilage tissue engineering.[1]

References

  1. Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells. Knippenberg, M., Helder, M.N., Zandieh Doulabi, B., Wuisman, P.I., Klein-Nulend, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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