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Satoh, J. et al.

Satoh, Tabunoki, Yamamura, Arima, Konno,

TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.

Nogo constitutes a family of neurite outgrowth inhibitors contributing to a failure of axonal regeneration in the adult central nervous system (CNS). Nogo-A is expressed exclusively on oligodendrocytes where Nogo-66 segment binds to Nogo receptor (NgR) expressed on neuronal axons. NgR signalling requires a coreceptor p75(NTR) or TROY in combination with an adaptor LINGO-1. To characterize the cell types expressing the NgR complex in the human CNS, we studied demyelinating lesions of multiple sclerosis ( MS) brains by immunohistochemistry. TROY and LINGO-1 were identified in subpopulations of reactive astrocytes, macrophages/microglia and neurones but not in oligodendrocytes. TROY was up-regulated, whereas LINGO-1 was reduced in MS brains by Western blot. These results suggest that the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of MS.[1]

References

TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Satoh, J., Tabunoki, H., Yamamura, T., Arima, K., Konno, H. Neuropathol. Appl. Neurobiol. (2007) [Pubmed]

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