Gene Review:
RTN4R - reticulon 4 receptor
Homo sapiens
Synonyms:
NGR, NOGOR, NgR, Nogo receptor, Nogo-66 receptor, ...
Satoh,
Tabunoki,
Yamamura,
Arima,
Konno,
Skaper,
Laurén,
Airaksinen,
Saarma,
Timmusk,
Satoh,
Onoue,
Arima,
Yamamura,
Walmsley,
Mir,
Frentzel,
Wen,
Wildes,
Silvian,
Walus,
Mi,
Lee,
Meier,
Pepinsky,
Mi,
Lee,
Shao,
Thill,
Ji,
Relton,
Levesque,
Allaire,
Perrin,
Sands,
Crowell,
Cate,
McCoy,
Pepinsky,
Walmsley,
McCombie,
Neumann,
Marcellin,
Hillenbrand,
Mir,
Frentzel,
- Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor. Walmsley, A.R., McCombie, G., Neumann, U., Marcellin, D., Hillenbrand, R., Mir, A.K., Frentzel, S. J. Cell. Sci. (2004)
- Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. Liao, H., Duka, T., Teng, F.Y., Sun, L., Bu, W.Y., Ahmed, S., Tang, B.L., Xiao, Z.C. J. Neurochem. (2004)
- Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis. Satoh, J., Onoue, H., Arima, K., Yamamura, T. J. Neuropathol. Exp. Neurol. (2005)
- Neuronal growth-promoting and inhibitory cues in neuroprotection and neuroregeneration. Skaper, S.D. Ann. N. Y. Acad. Sci. (2005)
- Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Pasqualini, R., Koivunen, E., Kain, R., Lahdenranta, J., Sakamoto, M., Stryhn, A., Ashmun, R.A., Shapiro, L.H., Arap, W., Ruoslahti, E. Cancer Res. (2000)
- Expression pattern of NOGO and NgR genes during human development. Al Halabiah, H., Delezoide, A.L., Cardona, A., Moalic, J.M., Simonneau, M. Gene Expr. Patterns (2005)
- Nogo-66 receptor antagonist peptide promotes axonal regeneration. GrandPré, T., Li, S., Strittmatter, S.M. Nature (2002)
- LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J., Levesque, M., Allaire, N., Perrin, S., Sands, B., Crowell, T., Cate, R.L., McCoy, J.M., Pepinsky, R.B. Nat. Neurosci. (2004)
- A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Wong, S.T., Henley, J.R., Kanning, K.C., Huang, K.H., Bothwell, M., Poo, M.M. Nat. Neurosci. (2002)
- Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases. Walmsley, A.R., Mir, A.K., Frentzel, S. Biochem. Biophys. Res. Commun. (2005)
- Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display. Schimmele, B., Plückthun, A. J. Mol. Biol. (2005)
- No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. Meng, J., Shi, Y., Zhao, X., Guo, S., Wang, H., Zheng, Y., Tang, R., Feng, G., Gu, N., Liu, H., Zhu, S., He, L. Journal of neural transmission (Vienna, Austria : 1996) (2007)
- Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. He, X.L., Bazan, J.F., McDermott, G., Park, J.B., Wang, K., Tessier-Lavigne, M., He, Z., Garcia, K.C. Neuron (2003)
- The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Dechant, G., Barde, Y.A. Nat. Neurosci. (2002)
- Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Laurén, J., Airaksinen, M.S., Saarma, M., Timmusk, T. Mol. Cell. Neurosci. (2003)
- Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. Josephson, A., Trifunovski, A., Widmer, H.R., Widenfalk, J., Olson, L., Spenger, C. J. Comp. Neurol. (2002)
- Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Domeniconi, M., Cao, Z., Spencer, T., Sivasankaran, R., Wang, K., Nikulina, E., Kimura, N., Cai, H., Deng, K., Gao, Y., He, Z., Filbin, M. Neuron (2002)
- Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor. Wen, D., Wildes, C.P., Silvian, L., Walus, L., Mi, S., Lee, D.H., Meier, W., Pepinsky, R.B. Biochemistry (2005)
- Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy. Pastorino, F., Brignole, C., Marimpietri, D., Cilli, M., Gambini, C., Ribatti, D., Longhi, R., Allen, T.M., Corti, A., Ponzoni, M. Cancer Res. (2003)
- Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif. Colombo, G., Curnis, F., De Mori, G.M., Gasparri, A., Longoni, C., Sacchi, A., Longhi, R., Corti, A. J. Biol. Chem. (2002)
- Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. Asokan, A., Hamra, J.B., Govindasamy, L., Agbandje-McKenna, M., Samulski, R.J. J. Virol. (2006)
- Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. Venturin, M., Moncini, S., Villa, V., Russo, S., Bonati, M.T., Larizza, L., Riva, P. Neurogenetics (2006)
- NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. Lee, X., Yang, Z., Shao, Z., Rosenberg, S.S., Levesque, M., Pepinsky, R.B., Qiu, M., Miller, R.H., Chan, J.R., Mi, S. J. Neurosci. (2007)
- TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Satoh, J., Tabunoki, H., Yamamura, T., Arima, K., Konno, H. Neuropathol. Appl. Neurobiol. (2007)
- The nogo-nogo receptor pathway limits a spectrum of adult CNS axonal growth. Cafferty, W.B., Strittmatter, S.M. J. Neurosci. (2006)
- Mutation in the leucine-rich repeat C-flanking region of platelet glycoprotein Ib beta impairs assembly of von Willebrand factor receptor. Tang, J., Stern-Nezer, S., Liu, P.C., Matyakhina, L., Riordan, M., Luban, N.L., Steinbach, P.J., Kaler, S.G. Thromb. Haemost. (2004)
- LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Majercak, J., Ray, W.J., Espeseth, A., Simon, A., Shi, X.P., Wolffe, C., Getty, K., Marine, S., Stec, E., Ferrer, M., Strulovici, B., Bartz, S., Gates, A., Xu, M., Huang, Q., Ma, L., Shughrue, P., Burchard, J., Colussi, D., Pietrak, B., Kahana, J., Beher, D., Rosahl, T., Shearman, M., Hazuda, D., Sachs, A.B., Koblan, K.S., Seabrook, G.R., Stone, D.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. Sinibaldi, L., De Luca, A., Bellacchio, E., Conti, E., Pasini, A., Paloscia, C., Spalletta, G., Caltagirone, C., Pizzuti, A., Dallapiccola, B. Hum. Mutat. (2004)
- Targeting Liposomal Chemotherapy via Both Tumor Cell-Specific and Tumor Vasculature-Specific Ligands Potentiates Therapeutic Efficacy. Pastorino, F., Brignole, C., Di Paolo, D., Nico, B., Pezzolo, A., Marimpietri, D., Pagnan, G., Piccardi, F., Cilli, M., Longhi, R., Ribatti, D., Corti, A., Allen, T.M., Ponzoni, M. Cancer Res. (2006)