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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

DNA methylation imprints on the IG-DMR of the Dlk1-Gtl2 domain in mouse male germline.

Mouse genomes show a large cluster of imprinted genes at the Dlk1-Gtl2 domain in the distal region of chromosome 12. An intergenic-differentially methylated region (IG-DMR) located between Dlk1 and Gtl2 is specifically methylated in the male germline; IG-DMR regulates the parental allele-specific expression of imprinted genes. Here, we show the resetting of IG-DMR methylation marks during male germ-cell differentiation. For parental allele-specific methylation analysis, polymorphisms were detected in a 2.6-kb IG-DMR in three mouse strains. Bisulfite methylation analysis showed erasure of the marks by E14 and re-establishment before birth. The IG-DMR methylation status was maintained in spermatogonia and spermatocytes of mature testes. The IG-DMR methylation status established before birth is thus maintained throughout the lifetime in the male germline.[1]


  1. DNA methylation imprints on the IG-DMR of the Dlk1-Gtl2 domain in mouse male germline. Hiura, H., Komiyama, J., Shirai, M., Obata, Y., Ogawa, H., Kono, T. FEBS Lett. (2007) [Pubmed]
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