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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Delayed puberty in the male Djungarian hamster: effect of short photoperiod or melatonin treatment on the GnRH neuronal system.

The effect of short days or timed melatonin treatments on the number and neuroanatomical location of gonadotropin-releasing hormone (GnRH) neurons was studied in the brain of the pubertal male Djungarian hamster. At the beginning of the rapid phase of testicular growth and onset of peak gonadotropin secretion (15 days of age), males were treated for 10 days with either short days (10 L:14 D; n = 6), or remained in long days (16 L:8 D; n = 5) and injected each afternoon with melatonin. These treatments arrested testicular growth compared to the gonadal development that occurred in long-day controls (n = 9). Every brain section (60 microns) from the olfactory bulb to the anterior hypothalamus was processed for GnRH immunocytochemistry and viewed under brightfield light microscopy. GnRH cell bodies had smooth contours and were morphologically bipolar or unipolar. The number of bipolar neurons was similar regardless of treatment (about 170/brain). However, fewer unipolar GnRH cell bodies (p less than 0.05) were found in males in short days (73 +/- 11) or in males administered melatonin (72 +/- 14) compared to the unipolar number in hamsters in long days (132 +/- 14). With respect to neuroanatomical distribution, significantly fewer unipolar GnRH neurons were found in the medial preoptic area of males treated with short days or melatonin (55-70% decrease) compared to cell numbers in long-day controls. The melatonin-treated hamsters also had reduced numbers of unipolar GnRH neurons in the diagonal band of Broca relative to the number of unipolar neurons in long-day controls.(ABSTRACT TRUNCATED AT 250 WORDS)[1]

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