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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Puberty, Delayed

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Disease relevance of Puberty, Delayed

  • SMPD3 plays a pivotal role in the control of late embryonic and postnatal development: the smpd3-null mouse develops a novel form of dwarfism and delayed puberty as part of a hypothalamus-induced combined pituitary hormone deficiency [1].
  • We measured nocturnal serum melatonin levels during the administration of 250 mg testosterone enantale/month for 4 months in 12 male patients with idiopathic hypogonadotropic hypogonadism (IGD; n = 6) and delayed puberty (DP; n = 6) [2].
  • Seven patients with precocious puberty and 12 with delayed puberty were also investigated and found to have MIS levels consistent with their degree of pubertal development [3].
  • Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene [4].
  • Prenatal treatment with 3 micrograms DESDP caused delayed puberty, impaired ovarian function, reduced responsiveness of lordosis to EB and P in adulthood (defeminization), augmented mounting in the absence of hormones (masculinization), and reduced responsiveness of mounting to exogenous EB and P in adulthood (defeminization) [5].

Psychiatry related information on Puberty, Delayed


High impact information on Puberty, Delayed


Chemical compound and disease context of Puberty, Delayed


Biological context of Puberty, Delayed


Anatomical context of Puberty, Delayed


Gene context of Puberty, Delayed

  • Delayed puberty was preceded by suppression of follicular growth, and decreased concentrations of IGF-I in serum and follicular fluid.(ABSTRACT TRUNCATED AT 400 WORDS)[25]
  • These results suggest that a normal PRL response to TRH in a male who has delayed puberty does not exclude the diagnosis of HH, but that a subnormal response probably does support that diagnosis [26].
  • We examined the genes encoding GPR54 and its putative endogenous ligand, kisspeptin-1, for mutations in a cohort of 30 patients with normosmic HH or delayed puberty [27].
  • They also suggest that the delayed puberty associated with GH deficiency or resistance is most likely related to an IGF-I deficiency [28].
  • Mutations in the aromatase gene in females have confirmed that its deficiency results in a previously unrecognized form of sexual ambiguity with a 46,XX karyotype, and delayed puberty with multicystic ovaries [29].

Analytical, diagnostic and therapeutic context of Puberty, Delayed


  1. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Stoffel, W., Jenke, B., Blöck, B., Zumbansen, M., Koebke, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing hormone deficiency. Luboshitzky, R., Lavi, S., Thuma, I., Lavie, P. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  3. Serum levels of mullerian inhibiting substance in boys throughout puberty and in the first two years of life. Baker, M.L., Hutson, J.M. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  4. Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. Pitteloud, N., Acierno, J.S., Meysing, A.U., Dwyer, A.A., Hayes, F.J., Crowley, W.F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  5. Estrogens before birth and development of sex-related reproductive traits in the female guinea pig. Hines, M., Goy, R.W. Hormones and behavior. (1985) [Pubmed]
  6. Penile size and growth in children and adolescents with isolated gonadotrophin defiency (IGnD). Laron, Z., Kaushanski, A., Josefsberg, Z. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  7. The role of sex hormone replacement therapy on self-perceived competence in adolescents with delayed puberty. Schwab, J., Kulin, H.E., Susman, E.J., Finkelstein, J.W., Chinchilli, V.M., Kunselman, S.J., Liben, L.S., D'Arcangelo, M.R., Demers, L.M. Child development. (2001) [Pubmed]
  8. The prolactin response to thyrotropin-releasing hormone differentiates isolated gonadotropin deficiency from delayed puberty. Spitz, I.M., Hirsch, H.J., Trestian, S. N. Engl. J. Med. (1983) [Pubmed]
  9. Use of a specific aromatase inhibitor in delayed puberty. Stanhope, R. Lancet (2001) [Pubmed]
  10. Rapid decrease in melatonin production during successful treatment of delayed puberty. Arendt, J., Labib, M.H., Bojkowski, C., Hanson, S., Marks, V. Lancet (1989) [Pubmed]
  11. Clinical value of adrenal androgen measurement in the diagnosis of delayed puberty. Cohen, H.N., Wallace, A.M., Beastall, G.H., Fogelman, I., Thomson, J.A. Lancet (1981) [Pubmed]
  12. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. Veldhuis, J.D., Metzger, D.L., Martha, P.M., Mauras, N., Kerrigan, J.R., Keenan, B., Rogol, A.D., Pincus, S.M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  13. Pulsatile gonadotropin-releasing hormone treatment in idiopathic delayed puberty. Wagner, T.O., Brabant, G., Warsch, F., Hesch, R.D., von zur Mühlen, A. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  14. Multiple hormone deficiencies in children with hemochromatosis. Oerter, K.E., Kamp, G.A., Munson, P.J., Nienhuis, A.W., Cassorla, F.G., Manasco, P.K. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  15. Differential response of serum LH in hypogonadotropic hypogonadism and delayed puberty to LH-RH stimulation before and after clomiphene citrate administration. Snoep, M.C., de Lange, W.E., Sluiter, W.J., Doorenbos, H. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  16. Oral testosterone undecanoate in the management of delayed puberty in boys: pharmacokinetics and effects on sexual maturation and growth. Butler, G.E., Sellar, R.E., Walker, R.F., Hendry, M., Kelnar, C.J., Wu, F.C. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  17. Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism. Arslanian, S., Suprasongsin, C. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  18. Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate--a clinical research center study. Salehian, B., Wang, C., Alexander, G., Davidson, T., McDonald, V., Berman, N., Dudley, R.E., Ziel, F., Swerdloff, R.S. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  19. Short-term delay of puberty causes a transient reduction in bone strength in growing female rats. Yingling, V.R., Khaneja, A. Bone (2006) [Pubmed]
  20. Leptin and thyroxine during sexual development in male monkeys: effect of neonatal gonadotropin-releasing hormone antagonist treatment and delayed puberty on the developmental pattern of leptin and thyroxine secretion. Mann, D.R., Akinbami, M.A., Gould, K.G., Castracane, V.D. Eur. J. Endocrinol. (2002) [Pubmed]
  21. Effects of age, photoperiod and follicle-stimulating hormone on lactate production by cultured Sertoli cells from prepubertal Siberian hamsters (Phodopus sungorus). Newton, S.C., Welsh, M.J., Bartke, A. J. Reprod. Fertil. (1992) [Pubmed]
  22. Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats. Kim, H.J., Sohn, H.J., Ha, M., Han, J.Y., Kang, S.S., Choi, W.S., Cho, G.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  23. Hypogonadism and Leydig cell hypoplasia unresponsive to human luteinizing hormone (hLH). Wu, R.H., Rosenfeld, R., Fukushima, D. Am. J. Med. Sci. (1984) [Pubmed]
  24. Somatomedin A levels in serum from healthy children and from children with growth hormone deficiency or delayed puberty. Hall, K., Enberg, G., Ritzén, M., Svan, H., Fryklund, L., Takano, K. Acta Endocrinol. (1980) [Pubmed]
  25. Endocrine events prior to puberty in heifers: role of somatotropin, insulin-like growth factor-I and insulin-like growth factor binding proteins. Armstrong, J.D., Stanko, R.L., Cohick, W.S., Simpson, R.B., Harvey, R.W., Huff, B.G., Clemmons, D.R., Whitacre, M.D., Campbell, R.M., Heimer, E.P. J. Physiol. Pharmacol. (1992) [Pubmed]
  26. The prolactin response to thyrotropin-releasing hormone does not distinguish teenaged males with hypogonadotropic hypogonadism from those with constitutional delay of growth and development. Moshang, T., Marx, B.S., Cara, J.F., Snyder, P.J. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  27. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. Semple, R.K., Achermann, J.C., Ellery, J., Farooqi, I.S., Karet, F.E., Stanhope, R.G., O'rahilly, S., Aparicio, S.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  28. Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice. Chatelain, P.G., Sanchez, P., Saez, J.M. Endocrinology (1991) [Pubmed]
  29. Molecular biology in reproductive endocrinology. Layman, L.C. Current opinion in obstetrics & gynecology. (1995) [Pubmed]
  30. LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Haavisto, A.M., Dunkel, L., Pettersson, K., Huhtaniemi, I. Pediatr. Res. (1990) [Pubmed]
  31. Effects of testosterone therapy for pubertal delay. Wilson, D.M., Kei, J., Hintz, R.L., Rosenfeld, R.G. Am. J. Dis. Child. (1988) [Pubmed]
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