- Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden. Tivesten, A., Mellström, D., Jutberger, H., Fagerberg, B., Lernfelt, B., Orwoll, E., Karlsson, M.K., Ljunggren, O., Ohlsson, C. J. Am. Coll. Cardiol. (2007)