The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat.

The effects of SK&F 96148, a thromboxane receptor blocking agent, on bronchoconstrictor responses were investigated in paralyzed, anesthetized, mechanically ventilated cats. I.v. injections of the thromboxane A2 (TXA2) mimics, U-46619 and U-44069, produced dose-related increases in transpulmonary pressure and lung resistance (RL) and decreases in dynamic compliance (Cdyn). After administration of SK&F 96148, 5 mg/kg i.v., bronchoconstrictor responses to U-46619 and U-44069 were reduced markedly, whereas airway responses to prostaglandin (PG) F2 alpha, serotonin, PGD2, or the PGD2 metabolite, 9 alpha, 11 beta-PGF2, were not altered. The duration of action of SK&F 96148 was greater than 2 h, and the TXA2 receptor blockade was overcome when 10-fold larger doses of the TXA2 mimics were administered. Bronchoconstrictor responses to arachidonic acid, platelet-activating factor (PAF), endothelin-1, and E. coli endotoxin were blocked by SK&F 96148. The present data suggest that SK&F 96148 has selective thromboxane receptor blocking activity in the airways of the cat, and that bronchoconstrictor responses to endothelin-1, arachidonic acid, PAF, and E. coli endotoxin are mediated in part by the formation of TXA2.[1]


  1. Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat. Dyson, M.C., Kadowitz, P.J. Eur. J. Pharmacol. (1991) [Pubmed]
WikiGenes - Universities