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Gene Review

EDN1  -  endothelin 1

Felis catus

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Disease relevance of EDN1


High impact information on EDN1

  • Stimulation of myocardial Na(+)-independent Cl(-)-HCO(3)(-) exchanger by angiotensin II is mediated by endogenous endothelin [6].
  • This effect was canceled by previous exposure to either 50 nmol/L PD 142,893 (nonselective endothelin receptor blocker) or 300 nmol/L BQ 123 (selective blocker of ET(A) receptors) [6].
  • Exposure to ET-1 (10 nmol/L) raised pH(i) by 0.13+/-0.03 U (P<0.05) in papillary muscles superfused with nominally HCO(3)(-)-free solution, whereas no significant change was detected under CO(2)/HCO(3)(-)-buffered medium [6].
  • The rate of pH(i) recovery from trimethylamine hydrochloride-induced intracellular alkaline load was enhanced so that net HCO(3) efflux increased about three times in the presence of ET-1 (2.74+/-0.25 versus 9.66+/-1.29 mmol. L(-1). min(-1) at pH(i) 7.55, P<0.05) [6].
  • The increased PMN adherence to thrombin- or histamine-stimulated endothelium, which was blocked by an anti-P-selectin monoclonal antibody, was also significantly attenuated by preincubation of coronary segments with (100 nmol/L) ET-1 [1].

Chemical compound and disease context of EDN1


Biological context of EDN1

  • Vasoconstrictions induced by endothelin were extremely prolonged, persisting for approximately 90 min after a single microapplication [11].
  • Low doses of ET-1 (0.01 and 0.1 nmol) elicited mild but significant reductions in CBV without changes in the systemic arterial blood pressure (SABP) [12].
  • The effects of intracarotidly injected endothelin (ET)-1 (0.01-3 nmol) on the local cerebral blood volume (CBV) in the parietotemporal cortex were examined by the photoelectric method in 17 anesthetized cats [12].
  • The perivascular co-application of PD156707 and ET-1 (10 nM) effected a dose-dependent attenuation of the ET-1 vasoconstrictive response (IC50 = 0.1 microM) [13].
  • In this study, we have examined basic mechanisms underlying the contractile response of cerebral vessels to endothelin using in vitro pharmacology and electrophysiology [14].

Anatomical context of EDN1


Associations of EDN1 with chemical compounds


Other interactions of EDN1


Analytical, diagnostic and therapeutic context of EDN1

  • Constriction/dilatation of the cerebral microvessels by intravascular endothelin-1 in cats [12].
  • Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia [13].
  • RIA of corresponding nonradiolabeled HPLC elution demonstrated a significantly increased release of PGE2, PGF2 alpha, and 12-HETE as well as 5-HETE in response to ET-1 stimulation [22].
  • 5-HETE release from ET-1-stimulated cells was further identified by gas chromatography/mass spectrometry (GC/MS) [22].
  • Real-time RT-PCR measurements of prepro-ET-1, -ET-2, and -ET-3 were performed before and 5, 15, and 30 min after stretch [23].


  1. Autocrine effects of endothelin-1 on leukocyte-endothelial interaction: stimulation of endothelin B receptor subtype reduces endothelial adhesiveness via a nitric oxide-dependent mechanism. Murohara, T., Lefer, A.M. Blood (1996) [Pubmed]
  2. Administration of selective endothelin receptor type A antagonist Ro 61-1790 does not improve outcome in focal cerebral ischemia in cat. Bhardwaj, A., Wu, Y., Hurn, P.D., Kirsch, J.R., Traystman, R.J. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  3. Endothelin acts in feline and canine cerebral arteries from the adventitial side. Mima, T., Yanagisawa, M., Shigeno, T., Saito, A., Goto, K., Takakura, K., Masaki, T. Stroke (1989) [Pubmed]
  4. Characterization of endothelin receptors in the cerebral vasculature and their lack of effect on spreading depression. Goadsby, P.J., Adner, M., Edvinsson, L. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  5. Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells. Husain, S., Abdel-Latif, A.A. Biochem. J. (1999) [Pubmed]
  6. Stimulation of myocardial Na(+)-independent Cl(-)-HCO(3)(-) exchanger by angiotensin II is mediated by endogenous endothelin. de Hurtado, M.C., Alvarez, B.V., Ennis, I.L., Cingolani, H.E. Circ. Res. (2000) [Pubmed]
  7. Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. Raval, P., Bingham, S., Aiyar, N., Elliott, J.D., Hunter, A.J., Ohlstein, E.H., Parsons, A.A. Br. J. Pharmacol. (1999) [Pubmed]
  8. Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. Rey, S., Del Rio, R., Iturriaga, R. Brain Res. (2006) [Pubmed]
  9. Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat. Dyson, M.C., Kadowitz, P.J. Eur. J. Pharmacol. (1991) [Pubmed]
  10. Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes. Jones, L.G. Life Sci. (1996) [Pubmed]
  11. Contractile responses to endothelin in feline cortical vessels in situ. Robinson, M.J., McCulloch, J. J. Cereb. Blood Flow Metab. (1990) [Pubmed]
  12. Constriction/dilatation of the cerebral microvessels by intravascular endothelin-1 in cats. Kobari, M., Fukuuchi, Y., Tomita, M., Tanahashi, N., Konno, S., Takeda, H. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  13. Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia. Patel, T.R., Galbraith, S., Graham, D.I., Hallak, H., Doherty, A.M., McCulloch, J. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  14. Mechanisms of action of endothelin on isolated feline cerebral arteries: in vitro pharmacology and electrophysiology. Jansen, I., Fallgren, B., Edvinsson, L. J. Cereb. Blood Flow Metab. (1989) [Pubmed]
  15. Endothelin-mediated positive inotropic effect induced by reactive oxygen species in isolated cardiac muscle. De Keulenaer, G.W., Andries, L.J., Sys, S.U., Brutsaert, D.L. Circ. Res. (1995) [Pubmed]
  16. Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. Remus, T.P., Zima, A.V., Bossuyt, J., Bare, D.J., Martin, J.L., Blatter, L.A., Bers, D.M., Mignery, G.A. J. Biol. Chem. (2006) [Pubmed]
  17. Analysis of the effects of candesartan on responses to angiotensin II in the hindquarters vascular bed of the cat. Champion, H.C., Bivalacqua, T.J., Lambert, D.G., McNamara, D.B., Kadowitz, P.J. J. Am. Soc. Nephrol. (1999) [Pubmed]
  18. Analysis of the effects of candesartan in the mesenteric vascular bed of the cat. Champion, H.C., Kadowitz, P.J. Hypertension (1997) [Pubmed]
  19. Endothelin-mediated vascular tone following focal cerebral ischaemia in the cat. Patel, T.R., Galbraith, S., McAuley, M.A., McCulloch, J. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  20. Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. McMahon, T.J., Hood, J.S., Nossaman, B.D., Ibrahim, I.N., Feng, C.J., Kadowitz, P.J. J. Appl. Physiol. (1991) [Pubmed]
  21. Endothelin produces pulmonary vasoconstriction and systemic vasodilation. Lippton, H.L., Hauth, T.A., Summer, W.R., Hyman, A.L. J. Appl. Physiol. (1989) [Pubmed]
  22. Production of eicosanoids in response to endothelin-1 and identification of specific endothelin-1 binding sites in airway epithelial cells. Wu, T., Rieves, R.D., Larivee, P., Logun, C., Lawrence, M.G., Shelhamer, J.H. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
  23. Endothelin isoforms and the response to myocardial stretch. Ennis, I.L., Garciarena, C.D., Pérez, N.G., Dulce, R.A., Camilión de Hurtado, M.C., Cingolani, H.E. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
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