Chemical Compound Review:
U-46619 (Z)-7-[(1R,4R,5S,6S)-5- [(E,3S)-3...
Synonyms:
CHEMBL521784, BSPBio_001534, SureCN12272421, CHEBI:583940, BML1-G04, ...
- In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Reddy, V.M., Meyrick, B., Wong, J., Khoor, A., Liddicoat, J.R., Hanley, F.L., Fineman, J.R. Circulation (1995)
- Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor. Ali, S., Davis, M.G., Becker, M.W., Dorn, G.W. J. Biol. Chem. (1993)
- The identification and characterization of oligodendrocyte thromboxane A2 receptors. Blackman, S.C., Dawson, G., Antonakis, K., Le Breton, G.C. J. Biol. Chem. (1998)
- Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity. Schermuly, R.T., Krupnik, E., Tenor, H., Schudt, C., Weissmann, N., Rose, F., Grimminger, F., Seeger, W., Walmrath, D., Ghofrani, H.A. Am. J. Respir. Crit. Care Med. (2001)
- Estrogen restores postischemic sensitivity to the thromboxane mimetic U46619 in rat pial artery. Qin, X., Hurn, P.D., Littleton-Kearney, M.T. J. Cereb. Blood Flow Metab. (2005)
- Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. Thomas, D.W., Mannon, R.B., Mannon, P.J., Latour, A., Oliver, J.A., Hoffman, M., Smithies, O., Koller, B.H., Coffman, T.M. J. Clin. Invest. (1998)
- Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. Craven, P.A., Studer, R.K., DeRubertis, F.R. J. Clin. Invest. (1994)
- Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin. Brass, L.F., Shaller, C.C., Belmonte, E.J. J. Clin. Invest. (1987)
- Thromboxane-receptor blockade increases water diuresis in cirrhotic patients with ascites. Laffi, G., Marra, F., Carloni, V., Azzena, G., De Feo, M.L., Pinzani, M., Tosti-Guerra, C., Gentilini, P. Gastroenterology (1992)
- Platelet activating factor raises intracellular calcium ion concentration in macrophages. Conrad, G.W., Rink, T.J. J. Cell Biol. (1986)
- Increased response to arachidonic acid and U-46619 and resistance to inhibitory prostaglandins in patients with chronic myeloproliferative disorders. Cortelazzo, S., Galli, M., Castagna, D., Viero, P., de Gaetano, G., Barbui, T. Thromb. Haemost. (1988)
- Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep. Bubb, K.J., Cock, M.L., Black, M.J., Dodic, M., Boon, W.M., Parkington, H.C., Harding, R., Tare, M. J. Physiol. (Lond.) (2007)
- Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. Citro, S., Ravasi, S., Rovati, G.E., Capra, V. Am. J. Respir. Cell Mol. Biol. (2005)
- U46619-mediated vasoconstriction of the fetal placental vasculature in vitro in normal and hypertensive pregnancies. Read, M.A., Leitch, I.M., Giles, W.B., Bisits, A.M., Boura, A.L., Walters, W.A. J. Hypertens. (1999)
- Hypoxia- and endothelium-mediated changes in the pharmacological responsiveness of circumflex coronary artery rings from the sheep. Kwan, Y.W., Wadsworth, R.M., Kane, K.A. Br. J. Pharmacol. (1989)
- Preliminary assessment of a novel thromboxane A2 receptor-blocking drug, GR32191, in healthy subjects. Thomas, M., Lumley, P. Circulation (1990)
- Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Frostell, C., Fratacci, M.D., Wain, J.C., Jones, R., Zapol, W.M. Circulation (1991)
- Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation. Hasan, A.A., Amenta, S., Schmaier, A.H. Circulation (1996)
- Thrombin-induced mitogenesis in coronary artery smooth muscle cells is potentiated by thromboxane A2 and involves upregulation of thromboxane receptor mRNA. Zucker, T.P., Bönisch, D., Muck, S., Weber, A.A., Bretschneider, E., Glusa, E., Schrör, K. Circulation (1998)
- Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. Gabbeta, J., Yang, X., Kowalska, M.A., Sun, L., Dhanasekaran, N., Rao, A.K. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Reoxygenation-induced relaxation of coronary arteries. A novel endothelium-dependent mechanism. Close, L.A., Bowman, P.S., Paul, R.J. Circ. Res. (1994)
- Role of endothelium-derived relaxing factor and prostaglandins in responses of coronary arteries to thromboxane in vivo. Szwajkun, K., Lamping, K.G., Dole, W.P. Circ. Res. (1990)
- Identification of functional PGH2/TxA2 receptors on human endothelial cells. Kent, K.C., Collins, L.J., Schwerin, F.T., Raychowdhury, M.K., Ware, J.A. Circ. Res. (1993)
- Cultured human vascular smooth muscle cells with functional thromboxane A2 receptors: measurement of U46619-induced 45calcium efflux. Dorn, G.W., Sens, D., Chaikhouni, A., Mais, D., Halushka, P.V. Circ. Res. (1987)
- Interaction between thromboxane A2 and 5-hydroxytryptamine receptor subtypes in human coronary arteries. Chester, A.H., Allen, S.P., Tadjkarimi, S., Yacoub, M.H. Circulation (1993)
- Disparate effects of the calcium-channel blockers, nifedipine and verapamil, on alpha 2-adrenergic receptors and thromboxane A2-induced aggregation of human platelets. Johnson, G.J., Leis, L.A., Francis, G.S. Circulation (1986)
- Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates. Yao, S.K., McNatt, J., Cui, K., Anderson, H.V., Maffrand, J.P., Buja, L.M., Willerson, J.T. Circulation (1993)
- Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Ge, T., Hughes, H., Junquero, D.C., Wu, K.K., Vanhoutte, P.M., Boulanger, C.M. Circ. Res. (1995)
- Prostaglandin E2 potentiates platelet aggregation by priming protein kinase C. Vezza, R., Roberti, R., Nenci, G.G., Gresele, P. Blood (1993)
- Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor. Miggin, S.M., Kinsella, B.T. Mol. Pharmacol. (2002)
- Thromboxane/prostaglandin endoperoxide-induced hypertrophy of rat vascular smooth muscle cells is signaled by protein kinase C-dependent increases in transforming growth factor-beta. Craven, P.A., Studer, R.K., DeRubertis, F.R. Hypertension (1996)
- Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. Obara, Y., Kurose, H., Nakahata, N. Mol. Pharmacol. (2005)
- Low-affinity thromboxane receptor mediates proliferation in cultured vascular smooth muscle cells of rats. Ko, F.N. Arterioscler. Thromb. Vasc. Biol. (1997)
- Neurokinin B is a paracrine vasodilator in the human fetal placental circulation. Brownbill, P., Bell, N.J., Woods, R.J., Lowry, P.J., Page, N.M., Sibley, C.P. J. Clin. Endocrinol. Metab. (2003)
- Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation. Rimar, S., Gillis, C.N. Circulation (1993)
- Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery. Kim, Y.D., Fomsgaard, J.S., Heim, K.F., Ramwell, P.W., Thomas, G., Kagan, E., Moore, S.P., Coughlin, S.S., Kuwahara, M., Analouei, A. Circulation (1992)
- Endothelium-derived relaxing factor released from canine femoral artery by acetylcholine cannot be identified as free nitric oxide by electron paramagnetic resonance spectroscopy. Greenberg, S.S., Wilcox, D.E., Rubanyi, G.M. Circ. Res. (1990)
- Heterogeneity in filamentous actin content among individual human blood platelets. Oda, A., Daley, J.F., Cabral, C., Kang, J.H., Smith, M., Salzman, E.W. Blood (1992)