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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Curcumin inhibits cell growth and induces apoptosis in a number of tumor cell lines and animal models.Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 8 g per day.The purpose of this study was to address the antitumor effect of curcumin on cutaneous T-cell lymphoma (CTCL) cell lines and peripheral blood mononuclear cells (PBMCs) from patients with CTCL compared with healthy donors' controls.Curcumin at 5-20 microM for 24 and 48 hours induced apoptosis in a time- and dose-dependent manner in three CTCL cell lines (namely MJ, Hut78, and HH).Curcumin at 5-20 microM for 48 hours also caused more apoptosis in patients' PBMCs compared with healthy donors' PBMCs (P<0.05).Curcumin decreased protein and mRNA expression levels of signal transducer and activator of transcription (STAT)-3, bcl-2, and survivin in three cell lines and in patients' PBMCs.Curcumin inhibited STAT-3 and IkappaB-alpha phosphorylation, as well as suppressed DNA binding of nuclear factor (NF)-kappaB in these cells.Caspase-3 was activated and poly (ADP-Ribose) polymerase was cleaved after curcumin treatment.These data suggest that curcumin selectively induces apoptosis in association with the downregulation of STAT-3 and NF-kappaB signaling pathways in CTCL cells.Our findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with CTCL.[1]
