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Chemical Compound Review

Poly ADP ribose     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: CHEBI:16960, AC1L1PVE, LS-190861, 26656-46-2, NCGC00163321-01, ...
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Analytical, diagnostic and therapeutic context of POLY ADENOSINE DIPHOSPHATE RIBOSE


  1. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. Oliver, F.J., Ménissier-de Murcia, J., Nacci, C., Decker, P., Andriantsitohaina, R., Muller, S., de la Rubia, G., Stoclet, J.C., de Murcia, G. EMBO J. (1999) [Pubmed]
  2. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Zingarelli, B., Salzman, A.L., Szabó, C. Circ. Res. (1998) [Pubmed]
  3. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. Chatterjee, P.K., Zacharowski, K., Cuzzocrea, S., Otto, M., Thiemermann, C. FASEB J. (2000) [Pubmed]
  4. Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells. Samuni, A.M., Kasid, U., Chuang, E.Y., Suy, S., Degraff, W., Krishna, M.C., Russo, A., Mitchell, J.B. Cancer Res. (2005) [Pubmed]
  5. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Suarez-Pinzon, W.L., Mabley, J.G., Power, R., Szabó, C., Rabinovitch, A. Diabetes (2003) [Pubmed]
  6. beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Boland, B., Campbell, V. Neurobiol. Aging (2003) [Pubmed]
  7. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl, P.N., Yemul, S., Xiang, Z., Ho, L., Haroutunian, V., Purohit, D., Mohs, R., Pasinetti, G.M. Arch. Neurol. (2003) [Pubmed]
  8. Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. Fan, T., Lu, H., Hu, H., Shi, L., McClarty, G.A., Nance, D.M., Greenberg, A.H., Zhong, G. J. Exp. Med. (1998) [Pubmed]
  9. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. Szabó, C., Lim, L.H., Cuzzocrea, S., Getting, S.J., Zingarelli, B., Flower, R.J., Salzman, A.L., Perretti, M. J. Exp. Med. (1997) [Pubmed]
  10. The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation. Aravind, L. Trends Biochem. Sci. (2001) [Pubmed]
  11. Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma. Marks, D.I., Rockman, S.P., Oziemski, M.A., Fox, R.M. J. Clin. Invest. (1990) [Pubmed]
  12. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. Schraufstatter, I.U., Hinshaw, D.B., Hyslop, P.A., Spragg, R.G., Cochrane, C.G. J. Clin. Invest. (1986) [Pubmed]
  13. Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Tentori, L., Portarena, I., Barbarino, M., Balduzzi, A., Levati, L., Vergati, M., Biroccio, A., Gold, B., Lombardi, M.L., Graziani, G. Mol. Pharmacol. (2003) [Pubmed]
  14. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase. Cookson, M.R., Ince, P.G., Shaw, P.J. J. Neurochem. (1998) [Pubmed]
  15. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. Liaudet, L., Szabó E, n.u.l.l., Timashpolsky, L., Virág, L., Cziráki, A., Szabó, C. Br. J. Pharmacol. (2001) [Pubmed]
  16. Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells. Hiromatsu, Y., Sato, M., Tanaka, K., Ishisaka, N., Kamachi, J., Nonaka, K. Immunology (1993) [Pubmed]
  17. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Cuzzocrea, S., Reiter, R.J. Eur. J. Pharmacol. (2001) [Pubmed]
  18. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. Wang, X., Zelenski, N.G., Yang, J., Sakai, J., Brown, M.S., Goldstein, J.L. EMBO J. (1996) [Pubmed]
  19. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Pieper, A.A., Verma, A., Zhang, J., Snyder, S.H. Trends Pharmacol. Sci. (1999) [Pubmed]
  20. Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome. Theron, T., Fousteri, M.I., Volker, M., Harries, L.W., Botta, E., Stefanini, M., Fujimoto, M., Andressoo, J.O., Mitchell, J., Jaspers, N.G., McDaniel, L.D., Mullenders, L.H., Lehmann, A.R. Mol. Cell. Biol. (2005) [Pubmed]
  21. A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family. Ghosh, A., Sarkar, S.N., Rowe, T.M., Sen, G.C. J. Biol. Chem. (2001) [Pubmed]
  22. Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest. Sarfaraz, S., Afaq, F., Adhami, V.M., Malik, A., Mukhtar, H. J. Biol. Chem. (2006) [Pubmed]
  23. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Soucie, E.L., Annis, M.G., Sedivy, J., Filmus, J., Leber, B., Andrews, D.W., Penn, L.Z. Mol. Cell. Biol. (2001) [Pubmed]
  24. Ethanol enhances ADP-ribosylation of protein in rat hepatocytes. Akinshola, B.E., Sharma, S., Potter, J.J., Mezey, E. Hepatology (1992) [Pubmed]
  25. Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury. Scott, G.S., Jakeman, L.B., Stokes, B.T., Szabó, C. Ann. Neurol. (1999) [Pubmed]
  26. Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells. Ae, K., Kobayashi, N., Sakuma, R., Ogata, T., Kuroda, H., Kawaguchi, N., Shinomiya, K., Kitamura, Y. Oncogene (2002) [Pubmed]
  27. Poly (ADP-ribose) polymerase activity during the growth cycle of mouse fibroblasts (LS cells). Stone, P.R., Shall, S. Exp. Cell Res. (1975) [Pubmed]
  28. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Perkins, C., Kim, C.N., Fang, G., Bhalla, K.N. Blood (2000) [Pubmed]
  29. Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling. Maestre, N., Tritton, T.R., Laurent, G., Jaffrézou, J.P. Cancer Res. (2001) [Pubmed]
  30. CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells. Artus, C., Maquarre, E., Moubarak, R.S., Delettre, C., Jasmin, C., Susin, S.A., Robert-Lézénès, J. Oncogene (2006) [Pubmed]
  31. XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. Caldecott, K.W., Aoufouchi, S., Johnson, P., Shall, S. Nucleic Acids Res. (1996) [Pubmed]
  32. Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Yunta, M., Lazo, P.A. Oncogene (2003) [Pubmed]
  33. Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1. Deng, Z., Atanasiu, C., Zhao, K., Marmorstein, R., Sbodio, J.I., Chi, N.W., Lieberman, P.M. J. Virol. (2005) [Pubmed]
  34. Activation of apoptotic and inflammatory pathways in dysfunctional donor hearts. Birks, E.J., Yacoub, M.H., Burton, P.S., Owen, V., Pomerance, A., O'Halloran, A., Banner, N.R., Khaghani, A., Latif, N. Transplantation (2000) [Pubmed]
  35. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. Le Gall, M., Chambard, J.C., Breittmayer, J.P., Grall, D., Pouysségur, J., Van Obberghen-Schilling, E. Mol. Biol. Cell (2000) [Pubmed]
  36. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Cuzzocrea, S., McDonald, M.C., Mazzon, E., Siriwardena, D., Calabrò, G., Britti, D., Mazzullo, G., De Sarro, A., Caputi, A.P., Thiemermann, C. Am. J. Pathol. (2000) [Pubmed]
  37. Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats. Stern, Y., Salzman, A., Cotton, R.T., Zingarelli, B. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  38. Overexpression of the mouse Fas gene in human Hep3B hepatoma cells overcomes their resistance to Fas-mediated apoptosis. Lamboley, C., Bringuier, A.F., Camus, E., Lardeux, B., Groyer, A., Feldmann, G. J. Hepatol. (2002) [Pubmed]
  39. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex. Simbulan-Rosenthal, C.M., Rosenthal, D.S., Hilz, H., Hickey, R., Malkas, L., Applegren, N., Wu, Y., Bers, G., Smulson, M.E. Biochemistry (1996) [Pubmed]
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