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Sakamoto, M. et al.

Mineshi Sakamoto, Hing Man Chan, José L. Domingo, Machi Kubota, Katsuyuki Murata, Hing Man Chan, José L. Domingo, Machi Kubota, Katsuyuki Murata,

Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer.

The developing brains of both fetuses and infants are susceptible to environmental contaminants. However, the contribution of breast-feeding to the element body burden in infants remains unclear. The main objective of this study was to investigate the changes in body burden of elements such as methylmercury, lead, arsenic, cadmium, and selenium in infants during a 3-month breast-feeding period compared with placental transfer of the elements. Element concentrations were measured in maternal and umbilical cord (fetus) red blood cells (RBCs) at parturition and in infant RBCs at 3 months. Most of the mercury in RBCs is in the methyl form, and the total mercury concentration in RBCs reflects methylmercury exposure. The mercury level in cord RBCs was approximately 1.5 times higher than that in mothers, while in infants, it declined by approximately 60% after 3-months' breast-feeding. The cord selenium level was similar to the maternal level, but declined approximately 75% after 3-months' breast-feeding in infants. Lead and arsenic concentrations in cord RBCs were about 60% of the maternal levels, and remained constant until the 3-month study period. The cadmium level in cord RBCs was about 20% of that in maternal RBCs, and remained almost constant until the end of the 3-month study period. In conclusion, although pregnant women should pay attention to avoid high methylmercury exposure, element exposure through breast-feeding does not pose any great concern in this population.[1]

References

Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Sakamoto, M., Chan, H.M., Domingo, J.L., Kubota, M., Murata, K. Ecotoxicol. Environ. Saf. (2012) [Pubmed]

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