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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth.

In Saccharomyces cerevisiae, the SCL-1 mutation is a dominant suppressor of the cycloheximide-resistant, temperature-sensitive (ts) lethal mutation, crl3 [McCusker and Haber, Genetics 119 (1988a) 303-315]. The wild-type scl1+ gene was isolated by screening subclones of the 35-kb region between TRP5 and LEU1 for restoration of the ts phenotype in an SCL1-1 crl3-2 strain. The scl1+ mRNA is about 900 nt long and encodes an open reading frame of 810 bp. The polypeptide deduced from scl1+ possesses a putative secretory signal peptide. The 5'-noncoding region may be under multiple controls, since it contains significant homology to the consensus sequences for the DNA-binding proteins, GCN4, GFI and, possibly, TUF. Gene disruption of scl1+ demonstrates that it is an essential gene.[1]


  1. The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. Balzi, E., Chen, W.N., Capieaux, E., McCusker, J.H., Haber, J.E., Goffeau, A. Gene (1989) [Pubmed]
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