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Gene Review

SCL1  -  proteasome core particle subunit alpha 1

Saccharomyces cerevisiae S288c

Synonyms: Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, PRC2, PRS2, Proteasome component C7-alpha, ...
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High impact information on SCL1


Biological context of SCL1


Associations of SCL1 with chemical compounds

  • Sequencing of J19 SCL1 showed that the glycine at position 226 in the Scl1 protein had been replaced by asparatic acid, suggesting that this mutation in the protein, a subunit of proteasomes, may be involved in the morphological change [3].

Regulatory relationships of SCL1

  • Surprisingly, the overall structure of the PRS2 gene was found to be identical to that of the suppressor scl1+ gene restoring the SCL1-1 mutation that suppresses crl3 cycloheximide-resistant, temperature-sensitive lethality [4].

Analytical, diagnostic and therapeutic context of SCL1


  1. Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. Hernando, Y., Carter, A.T., Parr, A., Hove-Jensen, B., Schweizer, M. J. Biol. Chem. (1999) [Pubmed]
  2. The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. Balzi, E., Chen, W.N., Capieaux, E., McCusker, J.H., Haber, J.E., Goffeau, A. Gene (1989) [Pubmed]
  3. Characterization of a Saccharomyces cerevisiae mutant with pseudohyphae and cloning of a gene complementing the mutation. Maneesri, J., Azuma, M., Torii, S., Igarashi, K., Ooshima, H. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  4. Molecular cloning of the yeast proteasome PRS2 gene identical to the suppressor gene scl1+. Lee, D.H., Tamura, T., Chung, C.H., Tanaka, K., Ichihara, A. Biochem. Int. (1991) [Pubmed]
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