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Gene Review

LEU1  -  3-isopropylmalate dehydratase LEU1

Saccharomyces cerevisiae S288c

Synonyms: 3-isopropylmalate dehydratase, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase, YGL009C
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High impact information on LEU1


Biological context of LEU1


Associations of LEU1 with chemical compounds


Physical interactions of LEU1

  • During mitosis, gene conversion events at the TRP5 locus on chromosome VII are coupled with conversion events at LEU1, a locus 18 cM away, 1200 times more frequently than would be expected for two independent acts of recombination [14].

Other interactions of LEU1


Analytical, diagnostic and therapeutic context of LEU1

  • Northern blots with a LEU1-specific probe showed the size of the LEU1 transcript (about 2.9 kb) is consistent with the size of the enzyme and steady state levels of the transcript are sharply reduced in cells grown in the presence of an elevated leucine concentration [15].
  • The restriction map of the 5 kb HindIII fragment and Southern blot analysis reveal that the cloned fragment contains the entire structural gene for the plasma membrane ATPase and the 5' end of the adjacent LEU1 gene [6].


  1. Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases. Serrano, R., Kielland-Brandt, M.C., Fink, G.R. Nature (1986) [Pubmed]
  2. LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Friden, P., Schimmel, P. Mol. Cell. Biol. (1987) [Pubmed]
  3. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. Wallace, M.A., Liou, L.L., Martins, J., Clement, M.H., Bailey, S., Longo, V.D., Valentine, J.S., Gralla, E.B. J. Biol. Chem. (2004) [Pubmed]
  4. The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., Goffeau, A. J. Biol. Chem. (1987) [Pubmed]
  5. Structure of yeast LEU4. The 5' flanking region contains features that predict two modes of control and two productive translation starts. Beltzer, J.P., Chang, L.F., Hinkkanen, A.E., Kohlhaw, G.B. J. Biol. Chem. (1986) [Pubmed]
  6. Genetic and molecular mapping of the pma1 mutation conferring vanadate resistance to the plasma membrane ATPase from Saccharomyces cerevisiae. Ulaszewski, S., Balzi, E., Goffeau, A. Mol. Gen. Genet. (1987) [Pubmed]
  7. Nucleotide sequencing analysis of a LEU gene of Candida maltosa which complements leuB mutation of Escherichia coli and leu2 mutation of Saccharomyces cerevisiae. Takagi, M., Kobayashi, N., Sugimoto, M., Fujii, T., Watari, J., Yano, K. Curr. Genet. (1987) [Pubmed]
  8. The behavior of insertions near a site of mitotic gene conversion in yeast. Golin, J.E., Falco, S.C. Genetics (1988) [Pubmed]
  9. Coincident gene conversion events in yeast that involve a large insertion. Golin, J.E., Falco, S.C., Margolskee, J.P. Genetics (1986) [Pubmed]
  10. Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: generation of tagged mutations in genes involved in hydrophobic substrate utilization. Mauersberger, S., Wang, H.J., Gaillardin, C., Barth, G., Nicaud, J.M. J. Bacteriol. (2001) [Pubmed]
  11. Genetics of borrelidin resistant mutants of Saccharomyces cerivisiae and properties of their threonyl-tRNA-synthetase. Nass, G., Poralla, K. Mol. Gen. Genet. (1976) [Pubmed]
  12. Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. Bigelis, R., Umbarger, H.E. J. Biol. Chem. (1976) [Pubmed]
  13. Evidence that alpha-isopropylmalate synthase of Saccharomyces cerevisiae is under the "general" control of amino acid biosynthesis. Hsu, Y.P., Kohlhaw, G.B., Niederberger, P. J. Bacteriol. (1982) [Pubmed]
  14. Coincident gene conversion during mitosis in saccharomyces. Golin, J.E., Esposito, M.S. Genetics (1984) [Pubmed]
  15. Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. Hsu, Y.P., Schimmel, P. J. Biol. Chem. (1984) [Pubmed]
  16. A Ser/Thr-rich multicopy suppressor of a cdc24 bud emergence defect. Bender, A., Pringle, J.R. Yeast (1992) [Pubmed]
  17. Properties of a trifluoroleucine-resistant mutant of Saccharomyces cerevisiae. Oba, T., Yamamoto, Y., Nomiyama, S., Suenaga, H., Muta, S., Tashiro, K., Kuhara, S. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  18. Biosynthesis of branched-chain amino acids in yeast: effect of carbon source on leucine biosynthetic enzymes. Brown, H.D., Satyanarayana, T., Umbarger, H.E. J. Bacteriol. (1975) [Pubmed]
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