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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Increased "pregnancy-specific" beta1-glycoprotein in certain nonseminomatous germ cell tumors.

Schwangerschafts (pregnancy) protein No. 1 ( SP1), a recently identified beta1-glycoprotein that occurs during pregnancy, was assayed in the sera of 97 men with germ cell tumors of the testis. SP1 was elevated at 11-440 ng/ml in 3 of 6 men with choriocarcinomas, in 5 of 17 men with teratomas or "teratocarcinomas" (embryonal carcinomas and teratomas), and in 5 of 50 men with embryonal carcinomas; the highest value in 143 patients with nonmalignant diseases was 9.1 ng/ml. None of 24 sera from men with seminomas and none of 5 sera from men with orchitis had elevated SP1. In the 1 patient examined, testicular choriocarcinoma SP1 had immunochemical and gel chromatographic properties similar to those of highly purified SP1 of placental origin.[1]

References

  1. Increased "pregnancy-specific" beta1-glycoprotein in certain nonseminomatous germ cell tumors. Rosen, S.W., Javadpour, N., Calvert, I., Kaminska, J. J. Natl. Cancer Inst. (1979) [Pubmed]
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